
NCBI . NLM . NIH . GOV {
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Title[redir]:
P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis - PMC
Description:
The pathway involving the tumor suppressor gene TP53 can regulate tumor angiogenesis by unclear mechanisms. Here we show that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107 (miR-107). We found that miR-107 is ...
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Keywords {🔍}
doi, cells, hifβ, expression, tumor, fig, pubmed, google, scholar, hct, cancer, hypoxia, cell, vegf, tumors, signaling, angiogenesis, mirna, pmc, human, decreases, vector, site, article, binding, levels, colon, measured, utr, hctwt, hypoxic, overexpression, data, reporter, control, gene, specimens, mice, hctp, transfected, free, hif, growth, protein, premir, vessels, regulation, increases, group, pathway,
Topics {✒️}
org/cgi/content/full/0911082107/dcsupplemental inhibit endogenous hif-1β hif-1β protein levels hif-1β-mir-107 response element full-length reporter construct hif-1α protein levels quantitative real-time pcr differentially regulated micro-rnas pmc beta search silencing hif-1β blocks hif-1α subunits form hypoxia inducible factor-1β mir-107 regulates hif-1β hypoxia-inducible factor-1 alpha pank3/pri-mir-103–1 behaves pmir-report luciferase vector hypoxia-inducible factor 1alpha pre-mir-scr + dfx hif-1β expression vector suppressing hif-1β expression hif-1β rescues cells alter hif-1α expression lv-gfp-mir-107-transduced cells pank1/mir-107 extending upstream mammalian oxygen-sensing pathway human colon cancer hypoxia-regulated gene vegf turn suppresses transcription von willebrand factor lv-gfp–infected cells supporting information online tab hif-1β supplementary materials included dna-damaging agents natl cancer inst hypoxia inducible factor-1 hypoxia-inducible factor 1 methods cell culture genomic human dna hif-1β blocks pgl3 promoter plasmid transcriptional start site gene encoding mir-107 hypoxia-inducible transcription mir-107 decreases expression inhibits cell growth potential binding element pre-mir-107 decreases license information pmcid hif-1β expression
Questions {❓}
- Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
- How do cells sense oxygen?
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