We are analyzing https://link.springer.com/article/10.1186/s12943-019-1099-7.

Title:
N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications | Molecular Cancer
Description:
Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m6A methylation has attracted increasing research interest in recent years. m6A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m6A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m6A in gastrointestinal tract cancers.
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Keywords {🔍}

pubmed, article, cancer, google, scholar, rna, mettl, cas, methylation, ythdf, central, expression, cell, modification, cells, mrna, fto, nmethyladenosine, important, role, pancreatic, alkbh, tumour, gastrointestinal, chen, tract, yth, protein, jiangsu, research, cancers, tumours, level, promotes, prognosis, translation, hcc, crc, nature, including, dna, studies, related, study, modifications, potential, metastasis, carcinoma, proliferation, found,

Topics {✒️}

augmented wnt/pi3k-akt signaling rna n6-methyladenosine-related genes human colon-cancer-initiating cells rna n6-methyladenosine methyltransferase rna n6-methyladenosine methyltransferase rna modification n6-methyladenosine n6-methyladenosine-dependent regulation s-adenosylmethionine-binding motif article download pdf wnt/beta-catenin pathway exhibits anti-inflammatory properties ythdf2-dependent posttranscriptional silencing transcriptome-wide research reveals m6a-dependent translation control post-transcriptional mrna processing acute myeloid leukemia anti-tumour immunity controlled trna m7g methylation n6-methyladenosine mettl14 m6a-modified rnas undergo lps-induced raw264 gastrointestinal tract cancers xiao-yan wang m6a-igf2bp2-dependent mechanism m6a-ythdf2-dependent mechanism privacy choices/manage cookies mammalian rna demethylase digestive tract tumors low mettl3/ythdf1 group full access oncogenic transcription factor zhen-jun gao c-myc digestive tract tumours promotes malignant phenotypes nf- κb signalling p38/erk pathways eukaryotic messenger rna m6a methylation complex yu fan european economic area wnt pathway component creative commons license gastrointestinal cancers suggest anti-inflammatory therapy m6a-demethylase complex m6a-dependent manner n6-methyladenosine article hu m6a rna methylation

Schema {🗺️}

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         description:Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m6A methylation has attracted increasing research interest in recent years. m6A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m6A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m6A in gastrointestinal tract cancers.
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      headline:N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
      description:Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m6A methylation has attracted increasing research interest in recent years. m6A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m6A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m6A in gastrointestinal tract cancers.
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      name:Cancer Institue, Affiliated People’s Hospital of Jiangsu University, Jiangsu Province, People’s Republic of China
      name:Digestive Department, Qingpu Branch Hospital of Affiliated Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China
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      name:Cancer Institue, Affiliated People’s Hospital of Jiangsu University, Jiangsu Province, People’s Republic of China

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