We are analyzing https://link.springer.com/article/10.1186/s12943-019-1033-z.

Title:
The role of m6A RNA methylation in human cancer | Molecular Cancer
Description:
N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m6A methyltransferases (METTL3/14, WTAP, RBM15/15B and KIAA1429, termed as “writers”), reverted by the demethylases (FTO and ALKBH5, termed as “erasers”) and recognized by m6A binding proteins (YTHDF1/2/3, IGF2BP1 and HNRNPA2B1, termed as “readers”). Acumulating evidence shows that, m6A RNA methylation has an outsize effect on RNA production/metabolism and participates in the pathogenesis of multiple diseases including cancers. Until now, the molecular mechanisms underlying m6A RNA methylation in various tumors have not been comprehensively clarified. In this review, we mainly summarize the recent advances in biological function of m6A modifications in human cancer and discuss the potential therapeutic strategies.
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Keywords {🔍}

pubmed, article, google, scholar, cas, rna, cell, cancer, central, mettl, modification, fto, mrna, methylation, nmethyladenosine, translation, protein, splicing, wang, modifications, cells, promotes, zhang, ythdf, alkbh, factor, aml, expression, regulates, res, tumor, processing, role, human, leukemia, liu, diseases, transcription, methyltransferase, carcinoma, development, mrnas, regulating, stem, inhibits, growth, proliferation, nature, rnas, wtap,

Topics {✒️}

aff4/nf-κb/myc signaling network 3′-azido-3′-deoxythymidine-resistant hiv-1 strains conventional ‘writer’-‘eraser’-‘reader’ paradigm targeting fto/m6a/myc/cebpa signaling hematopoietic stem/progenitor cells ccaat-enhancer binding protein n6-methyladenosine rna demethylase n6-methyladenosine rna methylation rna n6-methyladenosine methyltransferase rna n6-methyladenosine methyltransferase alkbh5-mediated m6a-demethylation m6a-mediated socs2 degradation jin-shui zhu n6-methyladenosine-dependent regulation article download pdf il-7/stat5/socs pathways [41] il-7/stat5/socs pathways m6a post-transcriptional modification post-transcriptional gene regulation ythdf2-dependent posttranscriptional silencing r-2hg-sensitive aml [24] steroidal anti-inflammatory drug wtap-wt1-tbl1 axis [81] wtap–wt1–tbl1 axis heat-shock-induced translation /α-ketoglutarate-dependent dioxygenases hbxip-induced mettl3 promotes carbonic anhydrase iv neural stem cells exhibits anti-leukemia effects regulated protein-rna interactome 3-deaza-adenosine analogs inhibition leukemia stem/initiation cells viral rna methylation dioxygenase-encoding fto gene regulating myb/myc axis r-2hg/spi1/fb23–2 rna methylation regulates regulates alternative splicing m6a-dependent translation control mammalian rna demethylase rna production/metabolism impacts rna metabolism anti-hiv-1 activity hematopoietic transcription factor pre-mrna splicing [32] related gene-gene heterogeneous nuclear ribonucleoprotein rna n6-methyladenosine n6-methyladenosine rna

Schema {🗺️}

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         headline:The role of m6A RNA methylation in human cancer
         description:N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m6A methyltransferases (METTL3/14, WTAP, RBM15/15B and KIAA1429, termed as “writers”), reverted by the demethylases (FTO and ALKBH5, termed as “erasers”) and recognized by m6A binding proteins (YTHDF1/2/3, IGF2BP1 and HNRNPA2B1, termed as “readers”). Acumulating evidence shows that, m6A RNA methylation has an outsize effect on RNA production/metabolism and participates in the pathogenesis of multiple diseases including cancers. Until now, the molecular mechanisms underlying m6A RNA methylation in various tumors have not been comprehensively clarified. In this review, we mainly summarize the recent advances in biological function of m6A modifications in human cancer and discuss the potential therapeutic strategies.
         datePublished:2019-05-29T00:00:00Z
         dateModified:2019-05-29T00:00:00Z
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            Cancer
            RNA methylation
            Prognosis
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            Cancer Research
            Oncology
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ScholarlyArticle:
      headline:The role of m6A RNA methylation in human cancer
      description:N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m6A methyltransferases (METTL3/14, WTAP, RBM15/15B and KIAA1429, termed as “writers”), reverted by the demethylases (FTO and ALKBH5, termed as “erasers”) and recognized by m6A binding proteins (YTHDF1/2/3, IGF2BP1 and HNRNPA2B1, termed as “readers”). Acumulating evidence shows that, m6A RNA methylation has an outsize effect on RNA production/metabolism and participates in the pathogenesis of multiple diseases including cancers. Until now, the molecular mechanisms underlying m6A RNA methylation in various tumors have not been comprehensively clarified. In this review, we mainly summarize the recent advances in biological function of m6A modifications in human cancer and discuss the potential therapeutic strategies.
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      dateModified:2019-05-29T00:00:00Z
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         N6-methyladenosine
         Cancer
         RNA methylation
         Prognosis
         Growth
         Metastasis
         Cancer Research
         Oncology
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      name:Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

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