We are analyzing https://link.springer.com/article/10.1186/bcr1856.

Title:
Re-evaluation of mammary stem cell biology based on in vivotransplantation | Breast Cancer Research
Description:
Over nearly half a century, transplantation methods have been employed to regenerate the mammary gland in vivo. Recent highly cited reports claim to have demonstrated the regeneration of an entire functional mammary gland from a single mammary epithelial cell. Nevertheless, re-examination of the literature on the transplantation biology of mammary gland regeneration reveals that a complex, combinatorial interaction between variously differentiated mammary epithelial cells and the mammary fat pad stroma is indispensable to this process. In the present article, these issues are reviewed and discussed to provide a greater understanding of the complexity of these multiplex interactions.
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Keywords {🔍}

mammary, cells, cell, epithelial, stem, pubmed, gland, google, scholar, article, cas, growth, transplantation, mouse, normal, populations, fat, progeny, outgrowths, epithelium, development, smith, ductal, produce, cancer, medina, senescence, lineagelimited, studies, serial, population, lobulelimited, breast, tissue, pimec, pads, stemprogenitor, biology, pad, transplanted, activity, vivo, alveolar, progenitors, hosts, demonstrated, functional, single, evidence, activities,

Topics {✒️}

adult wap-cre/rosa26r mice mmtv-induced mammary tumorigene-sis lineage-limited downstream stem/progenitor lineage-limited stem/progenitor cells duct-limited progenitor/stem cells lobule-limited progenitor/stem cells lobule-limited stem/progenitor cells lineage-limited stem/progenitor populations lineage-limited lobular stem/progenitors transformed lobule-limited stem/progenitors lobule-limited alveolar stem/progenitors lacz-positive pi-mec arose gfp+/cd49fhi-positive pi-mec parity-identified mammary cells gfp-/cd49flo epithelial cells lobule-limited progenitor activities wild-type mammary epithelium lineage-limited stem/progenitors duct-limited stem/progenitors early-stage hyperplastic lesions wild-type epithelial cells lobule-limited progenitor activity label-retaining epithelial cells pr-positive mammary epithelium wap-cre model renewing stem/progenitor populations immortalized lobule-limited progenitors long label-retaining cells lacz-positive myoepithelial cells duct-limited progenitors fail smooth muscle actin preneoplastic/neoplastic mammary cells lacz-positive luminal progeny stem/progenitor cell renewing premalignant/tumorigenic cell epithelial stem cell progenitor-mediated activities stem cell activities mammary stem cell epithelial cells enriched mouse mammary glands mouse mammary epithelium male/female chimeric outgrowths stem/progenitor cells mammary epithelial subtypes lineage-limited activities wap-cre mmtv-infected antecedent lobule-limited progenitor differentiated epithelial cells

Questions {❓}

First, what is the basis for growth senescence in regenerating mammary epithelial populations?
Second, how is growth senescence avoided in premalignant populations?
What are long label-retaining cells: unique to stem cells or mixed?
What have we learned recently about mammary stem cell biology from transplantation studies and where shall we go from here?
What is relevance of immortal lineage-limited transplantable populations to the cancer stem cell debate?
What role do these genes play in mammary stem cells or their immediate progeny (niche)?

Schema {🗺️}

WebPage:
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         headline:Re-evaluation of mammary stem cell biology based on in vivotransplantation
         description:Over nearly half a century, transplantation methods have been employed to regenerate the mammary gland in vivo. Recent highly cited reports claim to have demonstrated the regeneration of an entire functional mammary gland from a single mammary epithelial cell. Nevertheless, re-examination of the literature on the transplantation biology of mammary gland regeneration reveals that a complex, combinatorial interaction between variously differentiated mammary epithelial cells and the mammary fat pad stroma is indispensable to this process. In the present article, these issues are reviewed and discussed to provide a greater understanding of the complexity of these multiplex interactions.
         datePublished:2008-02-25T00:00:00Z
         dateModified:2008-02-25T00:00:00Z
         pageStart:1
         pageEnd:6
         sameAs:https://doi.org/10.1186/bcr1856
         keywords:
            Mammary Gland
            Mammary Epithelial Cell
            Mammary Epithelium
            Mammary Stem Cell
            Serial Transplantation
            Cancer Research
            Oncology
            Surgical Oncology
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ScholarlyArticle:
      headline:Re-evaluation of mammary stem cell biology based on in vivotransplantation
      description:Over nearly half a century, transplantation methods have been employed to regenerate the mammary gland in vivo. Recent highly cited reports claim to have demonstrated the regeneration of an entire functional mammary gland from a single mammary epithelial cell. Nevertheless, re-examination of the literature on the transplantation biology of mammary gland regeneration reveals that a complex, combinatorial interaction between variously differentiated mammary epithelial cells and the mammary fat pad stroma is indispensable to this process. In the present article, these issues are reviewed and discussed to provide a greater understanding of the complexity of these multiplex interactions.
      datePublished:2008-02-25T00:00:00Z
      dateModified:2008-02-25T00:00:00Z
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      keywords:
         Mammary Gland
         Mammary Epithelial Cell
         Mammary Epithelium
         Mammary Stem Cell
         Serial Transplantation
         Cancer Research
         Oncology
         Surgical Oncology
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            type:Person
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      name:BioMed Central
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      name:National Institutes of Health
      address:
         name:Mammary Stem Cell Biology Section, Mammary Biology And Tumorigenesis Laboratory, CCR, NCI, National Institutes of Health, Bethesda, USA
         type:PostalAddress
      name:Baylor College of Medicine, One Baylor Plaza
      address:
         name:Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, USA
         type:PostalAddress
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Person:
      name:Gilbert H Smith
      affiliation:
            name:National Institutes of Health
            address:
               name:Mammary Stem Cell Biology Section, Mammary Biology And Tumorigenesis Laboratory, CCR, NCI, National Institutes of Health, Bethesda, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Daniel Medina
      affiliation:
            name:Baylor College of Medicine, One Baylor Plaza
            address:
               name:Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, USA
               type:PostalAddress
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PostalAddress:
      name:Mammary Stem Cell Biology Section, Mammary Biology And Tumorigenesis Laboratory, CCR, NCI, National Institutes of Health, Bethesda, USA
      name:Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, USA

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