We are analyzing https://link.springer.com/article/10.1186/1476-4598-13-262.

Title:
Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention | Molecular Cancer
Description:
Despite decades of research, ovarian cancer is still associated with unacceptably high mortality rates, which must be addressed by novel therapeutic approaches. One avenue through which this may be achieved is targeting of tumor-initiating ‘Cancer Stem Cells’ (CSCs). CSCs are sufficient to generate primary and recurrent disease through extensive rounds of asymmetric division, which maintain the CSC pool while producing the tissues that form the bulk of the tumor. CSCs thrive in the harsh tumor niche, are generally refractory to therapeutic intervention and closely-linked to the Epithelial-Mesenchymal Transition process, which facilitates invasion and metastasis. While it is well-accepted that CSC-targeting must be assessed as a novel therapeutic avenue, few ovarian CSC models have been developed due to perceived and actual difficulties associated with the process of ‘CSC Discovery’. In this article we review contemporary approaches to CSC Discovery and argue that this process should start with an understanding of the specific challenges associated with clinical intervention, laying the pipeline backwards towards CSC Discovery. Such an approach would expedite the bridging of the gap between laboratory isolation and clinical targeting of ovarian CSCs.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Education
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

cancer, ovarian, cscs, cell, cells, csc, pubmed, stem, google, scholar, cas, central, differentiation, tumor, models, aldh, growth, expression, markers, identification, population, chemoresistance, disease, human, model, scs, discovery, therapeutic, state, research, properties, identify, chemoresistant, conditions, recurrent, shown, tumors, culture, specific, tumorigenesis, figure, stemness, xenograft, patient, factor, res, isolation, stable, lines, treatment,

Topics {✒️}

nf-κb-mediated mmp-9 upregulation pten/pi3k/akt pathway regulates stem-progenitor-differentiated cell hierarchies cd133-expressing stem cells ovarian cancer-initiating cells renewing tumor-initiating cells involve specific dna-monitoring unilateral anti-mitotic therapies single-cell asymmetric division embryonic stem cells magnetic-activated cell sorting long-established cell lines partial surgical de-bulking proteins search search heparin-binding growth factor ovarian cancer bio-markers open access license flow cytometry-based kit p53-independent apoptotic pathway cell-surface expressed proteins fluorescence-activated cell sorting easily-accessible starting point pro-vegf drug-treatment reduced progression-free survival article download pdf contemporary anti-proliferation approaches embryonal carcinoma 2102ep primitive hematopoietic cell single embryonal carcinoma epithelial-mesenchymal transition process cancer-specific csc markers neural stem cell cancer stem cell cancer stem cell cell stem cell cd44+/cd24+/esa+ phenotype ovarian cancer stem �cancer stem cells cancer stem cells permit patient-specific treatments müllerian inhibiting substance cancer cell lines cancer-initiating cell cd44+/myd88+ ovarian cscs p53-p21 signaling p38 mapk-mediated bmi-1 full size image human epithelial cancers cd44+/cd24-/lineage- phenotype stem cell factor

Questions {❓}

Alison MR, Guppy NJ, Lim SML, Nicholson LJ: Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose?
Ovarian cancer stem cells: still an elusive entity?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention
         description:Despite decades of research, ovarian cancer is still associated with unacceptably high mortality rates, which must be addressed by novel therapeutic approaches. One avenue through which this may be achieved is targeting of tumor-initiating ‘Cancer Stem Cells’ (CSCs). CSCs are sufficient to generate primary and recurrent disease through extensive rounds of asymmetric division, which maintain the CSC pool while producing the tissues that form the bulk of the tumor. CSCs thrive in the harsh tumor niche, are generally refractory to therapeutic intervention and closely-linked to the Epithelial-Mesenchymal Transition process, which facilitates invasion and metastasis. While it is well-accepted that CSC-targeting must be assessed as a novel therapeutic avenue, few ovarian CSC models have been developed due to perceived and actual difficulties associated with the process of ‘CSC Discovery’. In this article we review contemporary approaches to CSC Discovery and argue that this process should start with an understanding of the specific challenges associated with clinical intervention, laying the pipeline backwards towards CSC Discovery. Such an approach would expedite the bridging of the gap between laboratory isolation and clinical targeting of ovarian CSCs.
         datePublished:2014-12-11T00:00:00Z
         dateModified:2014-12-11T00:00:00Z
         pageStart:1
         pageEnd:15
         license:http://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/1476-4598-13-262
         keywords:
            Ovarian cancer
            Cancer stem cells
            Stem cell models
            Proliferate to kill
            Clonal cancer stemness
            Aldehyde dehydrogenase
            Hoechst
            Cluster of differentiation (CD) proteins
            Cancer Research
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig5_HTML.jpg
         isPartOf:
            name:Molecular Cancer
            issn:
               1476-4598
            volumeNumber:13
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Brendan Ffrench
               affiliation:
                     name:St James Hospital
                     address:
                        name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
                        type:PostalAddress
                     type:Organization
                     name:Coombe Women’s and Infants University Hospital
                     address:
                        name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Claudia Gasch
               affiliation:
                     name:St James Hospital
                     address:
                        name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
                        type:PostalAddress
                     type:Organization
                     name:Coombe Women’s and Infants University Hospital
                     address:
                        name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John J O’Leary
               affiliation:
                     name:St James Hospital
                     address:
                        name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
                        type:PostalAddress
                     type:Organization
                     name:Coombe Women’s and Infants University Hospital
                     address:
                        name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michael F Gallagher
               affiliation:
                     name:St James Hospital
                     address:
                        name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
                        type:PostalAddress
                     type:Organization
                     name:Coombe Women’s and Infants University Hospital
                     address:
                        name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Developing ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention
      description:Despite decades of research, ovarian cancer is still associated with unacceptably high mortality rates, which must be addressed by novel therapeutic approaches. One avenue through which this may be achieved is targeting of tumor-initiating ‘Cancer Stem Cells’ (CSCs). CSCs are sufficient to generate primary and recurrent disease through extensive rounds of asymmetric division, which maintain the CSC pool while producing the tissues that form the bulk of the tumor. CSCs thrive in the harsh tumor niche, are generally refractory to therapeutic intervention and closely-linked to the Epithelial-Mesenchymal Transition process, which facilitates invasion and metastasis. While it is well-accepted that CSC-targeting must be assessed as a novel therapeutic avenue, few ovarian CSC models have been developed due to perceived and actual difficulties associated with the process of ‘CSC Discovery’. In this article we review contemporary approaches to CSC Discovery and argue that this process should start with an understanding of the specific challenges associated with clinical intervention, laying the pipeline backwards towards CSC Discovery. Such an approach would expedite the bridging of the gap between laboratory isolation and clinical targeting of ovarian CSCs.
      datePublished:2014-12-11T00:00:00Z
      dateModified:2014-12-11T00:00:00Z
      pageStart:1
      pageEnd:15
      license:http://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/1476-4598-13-262
      keywords:
         Ovarian cancer
         Cancer stem cells
         Stem cell models
         Proliferate to kill
         Clonal cancer stemness
         Aldehyde dehydrogenase
         Hoechst
         Cluster of differentiation (CD) proteins
         Cancer Research
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2F1476-4598-13-262/MediaObjects/12943_2014_Article_1459_Fig5_HTML.jpg
      isPartOf:
         name:Molecular Cancer
         issn:
            1476-4598
         volumeNumber:13
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Brendan Ffrench
            affiliation:
                  name:St James Hospital
                  address:
                     name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
                     type:PostalAddress
                  type:Organization
                  name:Coombe Women’s and Infants University Hospital
                  address:
                     name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Claudia Gasch
            affiliation:
                  name:St James Hospital
                  address:
                     name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
                     type:PostalAddress
                  type:Organization
                  name:Coombe Women’s and Infants University Hospital
                  address:
                     name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John J O’Leary
            affiliation:
                  name:St James Hospital
                  address:
                     name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
                     type:PostalAddress
                  type:Organization
                  name:Coombe Women’s and Infants University Hospital
                  address:
                     name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael F Gallagher
            affiliation:
                  name:St James Hospital
                  address:
                     name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
                     type:PostalAddress
                  type:Organization
                  name:Coombe Women’s and Infants University Hospital
                  address:
                     name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Molecular Cancer
      issn:
         1476-4598
      volumeNumber:13
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:St James Hospital
      address:
         name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
         type:PostalAddress
      name:Coombe Women’s and Infants University Hospital
      address:
         name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
         type:PostalAddress
      name:St James Hospital
      address:
         name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
         type:PostalAddress
      name:Coombe Women’s and Infants University Hospital
      address:
         name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
         type:PostalAddress
      name:St James Hospital
      address:
         name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
         type:PostalAddress
      name:Coombe Women’s and Infants University Hospital
      address:
         name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
         type:PostalAddress
      name:St James Hospital
      address:
         name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
         type:PostalAddress
      name:Coombe Women’s and Infants University Hospital
      address:
         name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Brendan Ffrench
      affiliation:
            name:St James Hospital
            address:
               name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
               type:PostalAddress
            type:Organization
            name:Coombe Women’s and Infants University Hospital
            address:
               name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Claudia Gasch
      affiliation:
            name:St James Hospital
            address:
               name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
               type:PostalAddress
            type:Organization
            name:Coombe Women’s and Infants University Hospital
            address:
               name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
               type:PostalAddress
            type:Organization
      name:John J O’Leary
      affiliation:
            name:St James Hospital
            address:
               name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
               type:PostalAddress
            type:Organization
            name:Coombe Women’s and Infants University Hospital
            address:
               name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
               type:PostalAddress
            type:Organization
      name:Michael F Gallagher
      affiliation:
            name:St James Hospital
            address:
               name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
               type:PostalAddress
            type:Organization
            name:Coombe Women’s and Infants University Hospital
            address:
               name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
      name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
      name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
      name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
      name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
      name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland
      name:Department of Histopathology, Trinity College Dublin, Trinity Centre for Health Sciences, St James Hospital, Dublin 8, Ireland
      name:Pathology Department, Coombe Women’s and Infants University Hospital, Dublin 8, Ireland

External Links {🔗}(272)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.22s.

LINK . SPRINGER . COM {}