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Title[redir]:
SGLT-2 receptor inhibitors for treating patients with type 2 diabetes mellitus: a systematic review and network meta-analysis - PMC
Description:
Because of the lack of head-to-head trials, the aim was to indirectly compare sodium glucose transporter-2 (SGLT-2) inhibitors in the treatment of type 2 diabetes. Systematic review and network meta-analysis. MEDLINE and EMBASE were searched from ...
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Keywords {🔍}
hbac, patients, canagliflozin, diabetes, baseline, change, placebo, weight, type, sglt, therapy, dapagliflozin, monotherapy, weeks, figure, studies, outcomes, week, inhibitors, empagliflozin, trials, metformin, dual, treatment, study, network, reduction, sbp, doi, metaanalysis, data, controlled, cri, achieving, google, scholar, included, body, mgmetformin, bmi, pubmed, dapa, nma, doubleblind, open, proportion, placebocontrolled, placebometformin, cana, diet,
Topics {✒️}
uk/guidance/indevelopment/gid-tag441 4 uk/guidance/indevelopment/gid-tag471 28 dual-energy x-ray absorptiometry uk/guidance/ta288/chapter/1-guidance 2 uk/guidance/ta315/chapter/1-guidance 3 brooks-gelman-rubin statistic double-blind parallel-group rct renal-filtered glucose back high-density lipoprotein cholesterol pancreatic β-cell function pmc beta search network meta-analysis deepson long-term adverse effects standard pairwise meta-analysis parallel-group rct duration bayesian network meta-analysis drug-naive asian patients full-text screening 28 weeks open-label extension parallel-group comparative study oral glucose-lowering drugs evidence-based health-care evaluation methods information sources supplementary materials included intervention/outcomes dapagliflozin bailey publisher site pdf nice guidance ta288 nice guidance ta315 baseline seated sbp≥130 mmhg lavalle-gonzalez fj license information pmcid β-cell function systolic blood pressure network meta-analysis diastolic blood pressure phase iii study patients inadequately controlled united states government related transport system joined eli lilly sensitivity analysis including glucose-lowering effect serum lipid levels achieve glycaemic control pmc disclaimer selective outcome reporting single common comparator reached statistical significance reaching statistical significance active-controlled trial
Questions {❓}
- How valuable are multiple treatment comparison methods in evidence-based health-care evaluation?
- Is network meta-analysis as valid as standard pairwise meta-analysis?
- Would a change of that magnitude be enough to make a clinically meaningful difference in glycated haemoglobin (HbA1c), experienced once a day?
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