
NCBI . NLM . NIH . GOV {
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Title[redir]:
Dapagliflozin Monotherapy in Type 2 Diabetic Patients With Inadequate Glycemic Control by Diet and Exercise: A randomized, double-blind, placebo-controlled, phase 3 trial - PMC
Description:
Dapagliflozin, a highly selective inhibitor of the renal sodium-glucose cotransporter-2, increases urinary excretion of glucose and lowers plasma glucose levels in an insulin-independent manner. We evaluated the efficacy and safety of dapagliflozin ...
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Keywords {🔍}
dapagliflozin, diabetes, patients, baseline, study, glucose, dose, cohort, type, week, weight, placebo, google, scholar, doi, exploratory, treatment, data, pubmed, morning, evening, arms, blood, events, renal, change, fpg, table, main, pmc, infections, sglt, serum, effect, pressure, group, body, article, signs, suggestive, genital, cohorts, manuscript, nlm, control, inhibitor, excretion, efficacy, symptoms, hypoglycemia,
Topics {✒️}
high-sensitivity c-reactive protein renal sodium-glucose cotransporter-2 induces dose-dependent glucosuria sodium-glucose cotransport inhibition pmc beta search treatment-limiting side effects publisher site pdf high-a1c exploratory cohort exploratory high-a1c cohort newly insulin-treated patients fasting c-peptide ≥1 sodium-glucose cotransporter 2 open-label rescue medication license information pmcid net energy balance intensive glucose control pharmacokinetic half-life blood urea nitrogen seated blood pressure reach statistical significance diet/exercise counseling prospectively defined monitoring renal reabsorptive capacity fasting plasma glucose glucose excretion persisted newly detected hypertensives newly diagnosed diabetes exploratory evening dose meddra preferred term postbaseline bmi measurement serum uric acid clinical trial setting intensive glucose lowering improves glucose homeostasis dose-dependent increase urinary glucose excretion metabolic risk factors high a1c levels events included signs united states government motor vehicle accident symptomatic episode requiring bristol-myers squibb insulin-dependent diabetes severely uncontrolled diabetes plasma glucose multiplied reported signs/symptoms/events morning dose cohort sglt2 versus sglt1 inadequate glycemic control
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