We are analyzing https://link.springer.com/article/10.1007/s13277-014-2605-6.

Title:
Role of microRNA-93 in regulation of angiogenesis | Tumor Biology
Description:
Angiogenesis is essential for a wide variety of physiological and pathological processes. To date, many angiogenic microRNAs (miRNAs) have been identified and several of them were further investigated to elucidate the mechanisms of specific miRNAs in regulating angiogenesis. In recent studies concerning tumor and ischemia, the miRNA-93 had been demonstrated to be able to modulate angiogenesis in different molecular pathways. The miRNA-93 can promote angiogenesis via enhancing endothelial cell proliferation, migration, and tube formation. Additionally, miRNA-93-over-expressing cells developed a relationship with the blood vessels allowing tumor cells to survive and to grow well. However, high expression of miRNA-93 can depress the vascular endothelial growth factor (VEGF) secretion and its downstream molecular targets in in vivo and vitro experiments. MiRNA-93’s effects on angiogenesis are dependent on the interaction of other multiple genes and signal pathways, such as P21, E2F1, integrin-β8, LATS2, etc. Future investigation should involve mapping the network by which miRNA-93 exerts its functions.
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Topics {✒️}

month download article/chapter myc-activated microrna cluster tumor-suppressive pten cernas angiogenesis-related molecular targets microrna-dependent cross-talk anti-angiogenic activities microrna-92a controls angiogenesis dicer-dependent endothelial micrornas related subjects full article pdf privacy choices/manage cookies fish je mir-197 regulate expression cell growth dysregulation downstream molecular targets microrna/target duplexes article li reducing pro-angiogenic human gene biochim biophys acta expressing cells developed european economic area angiogenesis review published focal adhesion kinase human colorectal cancer article log mir-93 enhances angiogenesis cancer prevention center juntian liu affecting genes involved conditions privacy policy accepting optional cookies cell cycle pathway check access angiology angiogenesis mirnas putative rna-helicase targeting integrin-beta8 instant access micrornas modulating angiogenesis article cite mol cancer res growth factors enhances cell migration author information authors tumor angiogenesis journal finder publish tumor biol angiogenic factors siomi mc molecular pathways

Schema {🗺️}

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