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Title[redir]:
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster - PMC
Description:
Human adenocarcinomas commonly harbor mutations in the KRAS and MYC proto-oncogenes and the TP53 tumor suppressor gene. All three genetic lesions are potentially pro-angiogenic, as they sustain production of vascular endothelial growth factor ...
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Keywords {🔍}
cells, doi, myc, tumors, pubmed, google, scholar, ctgf, rasgfpmyc, fig, tumor, cell, levels, tsp, expression, rasgfp, pmc, analysis, protein, data, growth, raspuromir, angiogenesis, thrombospondin, article, colonocytes, cluster, oht, cancer, mouse, microrna, vegf, micrornas, tsr, supplementary, rna, free, performed, lysates, raspuro, human, gene, ras, nature, nlm, endothelial, neovascularization, oligoribonucleotides, neoplasms, rasgfpmycer,
Topics {✒️}
real-time quantitative rt-pcr large-caliber vascular channels /microarr/data%20analysis/affymetrix/methods real-time rt-pcr analysis turbo dna-free kit specific 2′-o-methyl oligoribonucleotides19 hypoxia-induced factor alpha p53-null mouse colonocytes horseradish peroxidase–conjugated forms fitc-conjugated lectin bound quantitative rt-pcr analysis myc-estrogen receptor fusion 2′-o-methyl oligoribonucleotides myc-transformed epithelial cells possess anti-angiogenic properties12 pmc beta search antisense-based microrna targeting retroviruses encoding k-ras solitary lectin-positive cells accession number e-mexp-757 myc-overexpressing tumors possessed human mir-17-92 pre-mirna colonocytes coexpressing k-ras partly restored expression lsm510 meta v3 lymphatic-specific lyve-1 marker sirna-induced rna silencing activated ki-ras gene single-cell rasgfpmycer clones vector-transduced raspuro cells vascular endothelial cells fitc-conjugated lectin antisense oligoribonucleotides targeting methods cell lines surrounding adipose tissue mir-17-92–transduced ras-cells mscv-mir-17-92–transduced cells affymetrix mas5 analysis p53-induced degradation myc-downregulated genes included enhanced chemiluminescence system tumor suppressor gene vesicular stomatitis virus rt-pcr performed mir-17-92-specific oligoribonucleotides endothelial cell migration ras-transformed colonocytes strand synthesis system mir-17-92–encoding retrovirus raspuromir cells promoted
Questions {❓}
- What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors?
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