We are analyzing https://link.springer.com/article/10.1007/s00395-017-0649-7.

Title:
MicroRNA-143 promotes cardiac ischemia-mediated mitochondrial impairment by the inhibition of protein kinase Cepsilon | Basic Research in Cardiology
Description:
The cardioprotection of protein kinase Cepsilon (PKCε) against myocardial infarction (MI) mediated by its anti-apoptotic property and underlying mechanism of targeted regulation by microRNA (miRNA) are not established. MI-induced injury, PKCε expression, and targeted regulation of miRNA-143 (miR-143) to PKCε have been evaluated using animal MI and cellular hypoxic models conjugated with series of state-of-art molecular techniques. The results demonstrated that PKCε significantly downregulated along with increased infarcted area and apoptotic and necrotic damage in MI model, and the targeted relationship and potential binding profile were established between miR-143 and PKCε. Both in vivo and in vitro ischemic tests showed that miR-143 induced apoptosis and necrosis, which was reversed by antagomiR-143 or AMO-143. The upregulation of miR-143 by transfection of miR-143 in vitro also induced cell loss, and this effect of miR-143 was completely reversed by co-transfection of miR-143 with AMO-143. The identically deleterious action of miR-143 on mitochondrial membrane potential and ATP synthesis was also observed in both animal MI and cellular hypoxic models, as well as miR-143 overexpressed models and converted by either antagomiR or AMO. Importantly, overexpression of miR-143 downregulated PKCε in all tested models and this downregulation was reversed in the presence of antagomiR or AMO. The direct targeted regulation of miR-143 on PKCε was confirmed by luciferase reporter and miRNA-masking tests. In conclusion, MI-mediated upregulation of miR-143 inhibits PKCε expression and consequently interference with the cardioprotection of PKCε to mitochondrial, and leads to mitochondrial membrane potential dissipation and myocardial death eventually.
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Keywords {🔍}

pubmed, article, google, scholar, cas, wang, central, cell, zhang, res, injury, microrna, mitochondrial, liu, apoptosis, heart, kinase, myocardial, cardiac, protein, ischemiareperfusion, protects, targeting, pkcε, death, basic, chen, yang, circ, zhao, research, cepsilon, zhou, infarction, ischemic, sun, pkcepsilon, cardiol, mol, inhibition, hong, expression, necrosis, inhibits, dois, cells, physiol, liang, models, cardiomyocytes,

Topics {✒️}

regulating cystathionine-gamma-lyase expression month download article/chapter cardiac ischemia/reperfusion injury myocardial ischemia/reperfusion injury /r-mediated myocardial injury nf-kappab pathway chemically modified microrna-143-3p myocardial ischaemia/reperfusion injury simulated ischaemia–reperfusion injury exerts tumor-suppressing functions f-fdg pet/ct yuhong zhou & rong zhang state-province key laboratories article basic research myocardial infarction post-transplantation microrna-143 promotes apoptosis permeability transition pore full article pdf myocardial ischemia–reperfusion mitochondrial permeability transition ischemia–reperfusion injury ischemia/reperfusion injury hypoxia-induced apoptosis competing financial interests mir-143 targets ctgf cardiac cell fate smooth muscle cells ischemia/reperfusion ipc protein kinase cepsilon mediates adverse remodelling cardiac ischemic injury hypoxic preconditioning promotes microrna-143 inhibits growth article hong targeting reperfusion injury acute myocardial infarction mitochondrial membrane potential privacy choices/manage cookies related subjects apoptosis-related micrornas microrna-92a protects microrna-125b protects cellular hypoxic models targeting protein kinase heartbeat regulates cardiogenesis microrna expression profile suppressing cell apoptosis mir-143 induced apoptosis de ferranti sd mi-induced injury

Questions {❓}

Duquesnes N, Lezoualc’h F, Crozatier B (2011) PKC-delta and PKC-epsilon: foes of the same family or strangers?

Schema {🗺️}

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         headline:MicroRNA-143 promotes cardiac ischemia-mediated mitochondrial impairment by the inhibition of protein kinase Cepsilon
         description:The cardioprotection of protein kinase Cepsilon (PKCε) against myocardial infarction (MI) mediated by its anti-apoptotic property and underlying mechanism of targeted regulation by microRNA (miRNA) are not established. MI-induced injury, PKCε expression, and targeted regulation of miRNA-143 (miR-143) to PKCε have been evaluated using animal MI and cellular hypoxic models conjugated with series of state-of-art molecular techniques. The results demonstrated that PKCε significantly downregulated along with increased infarcted area and apoptotic and necrotic damage in MI model, and the targeted relationship and potential binding profile were established between miR-143 and PKCε. Both in vivo and in vitro ischemic tests showed that miR-143 induced apoptosis and necrosis, which was reversed by antagomiR-143 or AMO-143. The upregulation of miR-143 by transfection of miR-143 in vitro also induced cell loss, and this effect of miR-143 was completely reversed by co-transfection of miR-143 with AMO-143. The identically deleterious action of miR-143 on mitochondrial membrane potential and ATP synthesis was also observed in both animal MI and cellular hypoxic models, as well as miR-143 overexpressed models and converted by either antagomiR or AMO. Importantly, overexpression of miR-143 downregulated PKCε in all tested models and this downregulation was reversed in the presence of antagomiR or AMO. The direct targeted regulation of miR-143 on PKCε was confirmed by luciferase reporter and miRNA-masking tests. In conclusion, MI-mediated upregulation of miR-143 inhibits PKCε expression and consequently interference with the cardioprotection of PKCε to mitochondrial, and leads to mitochondrial membrane potential dissipation and myocardial death eventually.
         datePublished:2017-09-08T00:00:00Z
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      headline:MicroRNA-143 promotes cardiac ischemia-mediated mitochondrial impairment by the inhibition of protein kinase Cepsilon
      description:The cardioprotection of protein kinase Cepsilon (PKCε) against myocardial infarction (MI) mediated by its anti-apoptotic property and underlying mechanism of targeted regulation by microRNA (miRNA) are not established. MI-induced injury, PKCε expression, and targeted regulation of miRNA-143 (miR-143) to PKCε have been evaluated using animal MI and cellular hypoxic models conjugated with series of state-of-art molecular techniques. The results demonstrated that PKCε significantly downregulated along with increased infarcted area and apoptotic and necrotic damage in MI model, and the targeted relationship and potential binding profile were established between miR-143 and PKCε. Both in vivo and in vitro ischemic tests showed that miR-143 induced apoptosis and necrosis, which was reversed by antagomiR-143 or AMO-143. The upregulation of miR-143 by transfection of miR-143 in vitro also induced cell loss, and this effect of miR-143 was completely reversed by co-transfection of miR-143 with AMO-143. The identically deleterious action of miR-143 on mitochondrial membrane potential and ATP synthesis was also observed in both animal MI and cellular hypoxic models, as well as miR-143 overexpressed models and converted by either antagomiR or AMO. Importantly, overexpression of miR-143 downregulated PKCε in all tested models and this downregulation was reversed in the presence of antagomiR or AMO. The direct targeted regulation of miR-143 on PKCε was confirmed by luciferase reporter and miRNA-masking tests. In conclusion, MI-mediated upregulation of miR-143 inhibits PKCε expression and consequently interference with the cardioprotection of PKCε to mitochondrial, and leads to mitochondrial membrane potential dissipation and myocardial death eventually.
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