
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mitochondrial PKCāε deficiency promotes I/Rāmediated myocardial injury via GSK3βādependent mitochondrial permeability transition pore opening - PMC
Description:
Mitochondrial fission is critically involved in cardiomyocyte apoptosis, which has been considered as one of the leading causes of ischaemia/reperfusion (I/R)āinduced myocardial injury. In our previous works, we demonstrate that aldehyde ...
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Keywords {š}
mitochondrial, aldh, mice, doi, pubmed, google, scholar, pkcΓ, ros, pkcε, myocardial, activation, stress, apoptosis, pmc, injury, mitochondria, drp, heart, article, cardiac, free, cardiomyocytes, cell, gskβ, translocation, role, protein, cardiomyocyte, min, phosphorylation, kinase, data, oxidative, reperfusion, fig, inhibition, opening, pkc, mptp, effect, deficiency, dysfunction, hrs, function, caspase, physiol, increased, hearts, isolated,
Topics {āļø}
protective pi3kāaktāgskā3beta signaling pkcāĪ“ādependent gskā3β activation mek/erk/gskā3beta pathway pavāmcmvāmediated mnsod gene rosādependent gskā3β signalling chlorpyrifosātreated shāsy5y cells ipcāmediated pkcāε played glycogen synthase kinaseā3β triggered redoxāsensitive pkcāĪ“ rosātriggered mitochondriaāmediated apoptosis hrpāconjugated antiāigg pkcāĪ“ādependent drp1 activation gskā3βādependent mptp opening ethanolāinduced cardiac protection pkcāεāmediated oxidative stress gskā3βāmediated mptp opening stressāmediated gskā3β phosphorylation ipcāinduced pkcāε activation ifnāgammaādependent autophagy pkcāĪ“āmediated mitochondria dysfunction pkcāĪ“ādependent pathway transfecting pkcāε shrna pkcdeltaāmediated ros production fluorescein antiāαmhc antibody regulates bax/bclā2 signaling pmc beta search promoted gskā3β phosphorylation induced gskā3β activation mitochondrialātriggered cardiomyocyte apoptosis phorbol esterāinduced cytochrome drp1āmediated mitochondrial fragmentation drp1āmediated mitochondrial swelling induces gskā3β activation pkcāĪ“ occur simultaneously computerāassisted planimetry software drp1āmediated mitochondrial dysfunction cytosolic jnk/p53 pathway upstream serineāthreonine kinases doubleābandāpass filter activated proāsurvival kinases streptozotocināinduced diabetic cardiomyopathy ipcāmediated protective effect redoxāsensitive pkcāĪ“ al reperfusionāinduced translocation stressāinduced ros production initiated mitochondrialātriggered apoptosis pmc copyright notice mitochondrial permeability transition mitochondrial transition pore pkcāĪ“ activation led
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