We are analyzing https://link.springer.com/article/10.1007/s00018-019-03039-y.

Title:
Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria | Cellular and Molecular Life Sciences
Description:
Oxygen is required for the survival of the majority of eukaryotic organisms, as it is important for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical energy in the form of adenosine triphosphate (ATP) generated from the catabolism of carbon-rich fuels such as glucose, lipids and glutamine. The intracellular sites of oxygen consumption-coupled ATP production are the mitochondria, double-membraned organelles that provide a dynamic and multifaceted role in cell signalling and metabolism. Highly evolutionarily conserved molecular mechanisms exist to sense and respond to changes in cellular oxygen levels. The primary transcriptional regulators of the response to decreased oxygen levels (hypoxia) are the hypoxia-inducible factors (HIFs), which play important roles in both physiological and pathophysiological contexts. In this review we explore the relationship between HIF-regulated signalling pathways and the mitochondria, including the regulation of mitochondrial metabolism, biogenesis and distribution.
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Keywords {🔍}

pubmed, article, google, scholar, mitochondrial, cas, hif, hypoxia, cell, central, mitochondria, hifα, oxygen, expression, cells, activity, protein, signalling, ros, biol, cancer, factor, metabolism, genes, cellular, hypoxiainducible, production, proteins, gene, biogenesis, stabilisation, atp, hypoxic, glutathione, fig, synthesis, sci, enzyme, cycle, transcriptional, regulation, enzymes, hifalpha, required, tca, upregulation, mol, intracellular, involved, shown,

Topics {✒️}

basic-helix-loop-helix-pas heterodimer regulated aryl-hydrocarbon-receptor nuclear translocator hif-1alpha-dependent nf-kappab activity cr-uk grant c7358/a11223 freiburg-warsaw-columbus pheochromocytoma study estrogen-related receptor alpha hypoxia-inducible factor-1alpha protein von-hippel lindau protein von hippel-lindau protein hypoxia-inducible factor-1 alpha-subunit article download pdf amp-activated protein kinase von hippel-lindau disease hif-1alpha-dependent gene expression meaningful alpha-proteobacterial phylogeny pgc-1α-regulated gene expression ros-mediated hif-1α stabilisation fatty acid-derived acetyl-coa hif-1alpha-inducible protein hypoxia-inducible factor 1alpha hypoxia-inducible factor-1alpha peptidyl prolyl-independent decarboxylation introduce single-strand breaks c-myc-regulated genes fatty acid-binding proteins hypoxia-inducible factor signalling affect hif-αprotein stability ten nuclear-encoded subunits cobalt stimulates hif-1-dependent cell-permeable 2-og derivatives ethidium bromide-mediated depletion hif-1α protein stabilisation ten nuclear-encoded cytochrome hypoxia-inducible factor induction hydroxylating hif-α proteins fatty acid-derived carbons creb-binding protein hif-1α-upregulated gene hif-regulated signalling pathways f1f0-type atp synthase cell-cycle-dependent investment hif-mediated subunit switching major oxygen-consuming organelle produce superoxide/hydrogen peroxide mrc grants mr/k002201/1 decreased drp1-dependent fission o2-regulated prolyl hydroxylation ros-scavenging antioxidant ebselen long-chain fatty acids relieves akap121-mediated suppression

Questions {❓}

Briston T, Yang J, Ashcroft M (2011) HIF-1alpha localization with mitochondria: a new role for an old favorite?
Ongwijitwat S, Wong-Riley MT (2005) Is nuclear respiratory factor 2 a master transcriptional coordinator for all ten nuclear-encoded cytochrome c oxidase subunits in neurons?

Schema {🗺️}

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      headline:Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria
      description:Oxygen is required for the survival of the majority of eukaryotic organisms, as it is important for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical energy in the form of adenosine triphosphate (ATP) generated from the catabolism of carbon-rich fuels such as glucose, lipids and glutamine. The intracellular sites of oxygen consumption-coupled ATP production are the mitochondria, double-membraned organelles that provide a dynamic and multifaceted role in cell signalling and metabolism. Highly evolutionarily conserved molecular mechanisms exist to sense and respond to changes in cellular oxygen levels. The primary transcriptional regulators of the response to decreased oxygen levels (hypoxia) are the hypoxia-inducible factors (HIFs), which play important roles in both physiological and pathophysiological contexts. In this review we explore the relationship between HIF-regulated signalling pathways and the mitochondria, including the regulation of mitochondrial metabolism, biogenesis and distribution.
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