We are analyzing https://link.springer.com/article/10.1007/s00018-012-1186-z.

Title:
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? | Cellular and Molecular Life Sciences
Description:
The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2, IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies have shown that these proteins act in various important aspects of cell function, such as cell polarization, migration, morphology, metabolism, proliferation and differentiation. In this review, we discuss the IGF2BP family’s role in cancer biology and how this correlates with their proposed functions during embryogenesis. IGF2BPs are mainly expressed in the embryo, in contrast with comparatively lower or negotiable levels in adult tissues. IGF2BP1 and IGF2BP3 have been found to be re-expressed in several aggressive cancer types. Control of IGF2BPs’ expression is not well understood; however, let-7 microRNAs, β-catenin (CTNNB1) and MYC have been proposed to be involved in their regulation. In contrast to many other RNA-binding proteins, IGF2BPs are almost exclusively observed in the cytoplasm where they associate with target mRNAs in cytoplasmic ribonucleoprotein complexes (mRNPs). During development, IGF2BPs are required for proper nerve cell migration and morphological development, presumably involving the control of cytoskeletal remodeling and dynamics, respectively. Likewise, IGF2BPs modulate cell polarization, adhesion and migration in tumor-derived cells. Moreover, they are highly associated with cancer metastasis and the expression of oncogenic factors (KRAS, MYC and MDR1). However, a pro-metastatic role of IGF2BPs remains controversial due to the lack of ‘classical’ in vivo studies. Nonetheless, IGF2BPs could provide valuable targets in cancer treatment with many of their in vivo roles to be fully elucidated.
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Keywords {🔍}

igfbp, article, google, scholar, pubmed, expression, protein, cas, cell, igfbps, mrna, cancer, role, cells, studies, imp, proteins, growth, rnabinding, migration, observed, rna, family, mrnas, development, control, pathol, factor, translation, vitro, binding, evidence, fig, proposed, igf, myc, transcripts, mrnabinding, target, actb, insulinlike, mice, nielsen, cytoplasmic, regulation, reported, tumor, expressed, tissues, metastasis,

Topics {✒️}

igf-ii mrna-binding proteins igf-ii mrna-binding protein mrna-binding protein crd-bp rna-binding protein crd-bp anti-parallel pseudo-dimer conformation crd-bp shields c-myc silico-predicted poly-adenylation sites di-domains affects rna-binding marcell lederer & stefan hüttelmaier zipcode-binding protein modulates c-myc mrna half-life untranslated-region-dependent translation regulation crd-bp mediates stabilization rna-binding protein igf2bp2/imp2 article download pdf rna-binding protein vickz semi-quantitative rt-pcr analysis regulatory rna-binding proteins beta-actin mrna localization s100a4-protein immunoreactivity improves rna-binding protein imp-3 rna-binding protein imp-2 individual rna-binding proteins multi-drug-resistance factor 1 actin-driven cell migration alternative poly-adenylation sites laminin-beta2 mrna translation mediating chemo-/radio-resistance photoactivatable ribonucleoside-enhanced crosslinking transcript-specific mrnp compositions rna-binding protein imp3 di sant’agnese pa martin-luther-university halle zipcode binding protein surprisingly long half-life �post-transcriptional fine tuner triple-negative breast carcinoma hypothesis requires protein–rna igf-ii expression rna-binding protein insulin 69-kda rna-binding protein semi-quantitative rt-pcr c-myc mrna stability specific-transcript binding inhibition crd-bp/imp-1 studying protein–rna association �stable’ protein–rna complexes src-directed tyrosine phosphorylation crd binding protein cytoplasmic protein–rna complexes

Questions {❓}

However, why do we observe translational silencing of some target mRNAs whereas the association of IGF2BPs with other transcripts prevents their premature decay?
IGF2BP1—oncogene(ic) or not?
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
What is the role of IGF2BP3 in cancer?

Schema {🗺️}

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         headline:Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
         description:The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2, IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies have shown that these proteins act in various important aspects of cell function, such as cell polarization, migration, morphology, metabolism, proliferation and differentiation. In this review, we discuss the IGF2BP family’s role in cancer biology and how this correlates with their proposed functions during embryogenesis. IGF2BPs are mainly expressed in the embryo, in contrast with comparatively lower or negotiable levels in adult tissues. IGF2BP1 and IGF2BP3 have been found to be re-expressed in several aggressive cancer types. Control of IGF2BPs’ expression is not well understood; however, let-7 microRNAs, β-catenin (CTNNB1) and MYC have been proposed to be involved in their regulation. In contrast to many other RNA-binding proteins, IGF2BPs are almost exclusively observed in the cytoplasm where they associate with target mRNAs in cytoplasmic ribonucleoprotein complexes (mRNPs). During development, IGF2BPs are required for proper nerve cell migration and morphological development, presumably involving the control of cytoskeletal remodeling and dynamics, respectively. Likewise, IGF2BPs modulate cell polarization, adhesion and migration in tumor-derived cells. Moreover, they are highly associated with cancer metastasis and the expression of oncogenic factors (KRAS, MYC and MDR1). However, a pro-metastatic role of IGF2BPs remains controversial due to the lack of ‘classical’ in vivo studies. Nonetheless, IGF2BPs could provide valuable targets in cancer treatment with many of their in vivo roles to be fully elucidated.
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      headline:Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?
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         general
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         Biochemistry
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