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Title[redir]:
The American Journal of Surgical Pathology
Description:
expression pattern and diagnostic value of IMP3 in Barrett esophagus, dysplasia, and carcinoma. A total of 217 cases (resection, n=56; biopsy, n=161) with 302 lesions (invasive esophageal adenocarcinoma, n=147; metastatic esophageal adenocarcinoma, n=14; high-grade dysplasia of the esophagus, n=52; low-grade dysplasia of the esophagus gland, n=21; and Barrett esophagus, n=68) were examined by immunohistochemistry for IMP3 expression. IMP3 showed strong cytoplasmic granular staining in 138 of 147 (94%) of invasive esophageal adenocarcinomas, 13 of 14 (93%) of metastatic esophageal adenocarcinomas, and 49 of 52 (94%) of high-grade dysplasias. In contrast, 3/21 (14%) of low-grade dysplasia and 5/68 (7%) Barrett esophagus were positive for IMP3. Expression of IMP3 was not found in adjacent benign squamous and glandular mucosa. Our findings indicate that IMP3 is a highly sensitive and specific biomarker for the diagnosis of invasive esophageal adenocarcinoma and high-grade dysplasia. The data also suggest that IMP3, an oncofetal protein, may play an important role in malignant transformation in esophageal adenocarcinoma....
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Keywords {🔍}
journal, imp, esophageal, dysplasia, adenocarcinoma, esophagus, issue, highgrade, barrett, access, subscribe, alerts, articles, authors, abstract, oncofetal, protein, expression, invasive, log, register, logo, issues, buy, diagnosis, metastatic, lowgrade, adenocarcinomas, data, text, subscribers, request, browse, content, submit, service, privacy, policy, secondary, advanced, search, info, previous, original, molecular, marker, detection, vohra, poonam, chu,
Topics {✒️}
journal authors submit full text access high-grade dysplasias clinical decision-making aggressive tumor behavior adjacent benign squamous artificial intelligence training high-grade dysplasia low-grade dysplasia invasive esophageal adenocarcinomas metastatic esophageal adenocarcinomas invasive esophageal adenocarcinoma metastatic esophageal adenocarcinoma etoc alerts service request 800-638-3030 register subscribe individual subscribers log oncofetal protein imp3 american journal journal tables issue esophageal adenocarcinoma website subscribe oncofetal protein journal center submit molecular marker di md poonam md bruce md surgical pathology 33 patient management glandular mucosa highly sensitive specific biomarker important role malignant transformation email inbox rights reserved barrett esophagus esophagus gland expression pattern imp3 expression data mining diagnosis authors content dysplasia adenocarcinoma log
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