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The American Journal of Surgical Pathology
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as a biomarker to distinguish between malignant and reactive mesothelial cells. A total of 109 cases (mesothelioma, n=45; reactive mesothelial proliferation, n=64) were examined by immunohistochemistry for IMP3 expression. IMP3 showed strong cytoplasmic staining in 33 of 45 (73%) mesothelioma cases. In contrast, the expression of IMP3 was undetectable in all (64 cases) benign reactive mesothelial proliferations. Among the IMP3-positive mesotheliomas, 27 (82%) exhibited diffuse IMP3 expression. The vast majority of IMP3-positive subtypes of mesotheliomas showed IMP3 expression in >50% of malignant cells, as this diffuse staining pattern occurred in 17 (81%) cases of epithelial, 4 (100%) cases of sarcomatoid, and 6 (75%) cases of mixed types of mesothelioma. In addition, 2 cases, which were initially diagnosed as atypical mesothelial proliferations and later confirmed to be mesotheliomas, showed diffuse IMP3 expression. Our findings suggest that IMP3 is a new positive biomarker for malignant mesothelioma. IMP3 immunohistochemical staining can be used as an adjunct tool in the distinction of malignant mesothelioma from reactive mesothelial proliferations....
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Keywords {🔍}
imp, journal, mesothelioma, mesothelial, cases, malignant, reactive, expression, issue, proliferation, access, subscribe, alerts, articles, authors, abstract, protein, biomarker, showed, staining, proliferations, mesotheliomas, diffuse, log, register, logo, issues, oncofetal, distinguish, phd, surgical, buy, distinction, growth, factor, cells, benign, imppositive, immunohistochemical, text, subscribers, request, article, browse, content, submit, service, privacy, policy, secondary,
Topics {✒️}
0b013e318218985b buy abstract reactive mesothelial proliferation reactive mesothelial proliferations imp3 immunohistochemical staining journal authors submit full text access atypical mesothelial proliferations clonal cellular proliferation benign fibromatous tumors reactive mesothelial cells oncofetal protein read immunohistochemical expression prostatic carcinoma subsequent large-cell change artificial intelligence training imp3-positive subtypes imp3-positive mesotheliomas etoc alerts service request 800-638-3030 register subscribe individual subscribers log american journal journal tables imp3 expression distinguish malignant mesothelioma issue website subscribe journal malignant cells center submit positive biomarker karen bsc surgical pathology 35 major challenge surgical pathologists vast majority mixed types initially diagnosed findings suggest adjunct tool glycoprotein a-80 desmoid tumor pcr amplification paratesticular region email inbox rights reserved data mining min md peiguo md kristine md
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