We are analyzing https://link.springer.com/article/10.1007/s00415-023-11634-0.

Title:
Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis | Journal of Neurology
Description:
The term ‘neuromyelitis optica spectrum disorders’ (NMOSD) is used as an umbrella term that refers to aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica (NMO) and its formes frustes and to a number of closely related clinical syndromes without AQP4-IgG. NMOSD were originally considered subvariants of multiple sclerosis (MS) but are now widely recognized as disorders in their own right that are distinct from MS with regard to immunopathogenesis, clinical presentation, optimum treatment, and prognosis. In part 1 of this two-part article series, which ties in with our 2014 recommendations, the neuromyelitis optica study group (NEMOS) gives updated recommendations on the diagnosis and differential diagnosis of NMOSD. A key focus is on differentiating NMOSD from MS and from myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD), which shares significant similarity with NMOSD with regard to clinical and, partly, radiological presentation, but is a pathogenetically distinct disease. In part 2, we provide updated recommendations on the treatment of NMOSD, covering all newly approved drugs as well as established treatment options.
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Keywords {🔍}

pubmed, article, google, scholar, nmosd, optica, neuromyelitis, germany, patients, neurol, university, central, spectrum, cas, lesions, diagnosis, aqpiggpositive, paul, study, mogemmogad, jarius, mri, disorders, kim, clinical, disease, criteria, aqpigg, optic, spinal, berlin, wildemann, aktas, disorder, group, acute, diagnostic, hospital, neurology, myelitis, cord, mult, scler, kleiter, antibodies, csf, ruprecht, aquaporin, brain, treatment,

Topics {✒️}

n-methyl-d-aspartate nmo fluid-attenuated inversion recovery guthy-jackson charitable foundation developing aqp4-igg-positive nmosd pediatric aqp4-igg-positive cohort aqp4-igg-positive nmosd exist article download pdf representing blood–brain barrier damage mog-igg cell-based assays aqp4-igg-positive nmosd cohort aqp4-igg-positive patients accounted mog-em/mogad affects women pencil-thin ependymal enhancement enzyme-linked immunosorbent assay myelin-oligodendrocyte glycoprotein antibody dietrich-bonhoeffer clinic neubrandenburg enzyme-linked immunosorbent assays optic nerve disk/head isar-amper klinik ost aqp4-igg-positive nmosd patients blood–brain barrier breakdown blood-brain barrier breakdown blood-brain barrier disruption kliniken südostbayern-klinikum traunstein typically longitudinally extensive—extending fluorescence-based immunoprecipitation assays vestische caritas-kliniken gmbh ludwig-maximilians-universität münchen ludwig-maximilians- universität münchen positive aqp4-igg serostatus positive aqp4-igg serostatus” csf l-lactate levels central nervous system helios vogtland-klinikum plauen myelin oligodendrocyte glycoprotein-immunoglobulin mvz johanna-odebrecht- stiftung typically aqp4-igg-positive b-cell chemoattractant cxcl13 blood–csf barrier dysfunction axial t2-weighted images �serum aqp4-igg positive unknown aqp4-igg serostatus unknown aqp4-igg serostatus” axial t2-weighted mri negative aqp4-igg serostatus aqp4-igg-negative serostatus” myelin-oligodendrocyte glycoprotein antibodies mixed aqp4-igg-positive persistently gadolinium-enhancing lesion neutrophil-related chemokines cxcl1

Questions {❓}

How does anti-AQP4 Ab involve PNS?
How should NMOSD be diagnosed?
Jarius S, Wildemann B (2019) Devic’s index case: a critical reappraisal—AQP4-IgG-mediated neuromyelitis optica spectrum disorder, or rather MOG encephalomyelitis?
Kleiter I, Hellwig K, Berthele A, Kumpfel T, Linker RA, Hartung HP, Paul F, Aktas O, for the Neuromyelitis Optica Study Group (NEMOS) (2012) Is it too early to predict the failure of natalizumab in NMO?
Solomon JM, Paul F, Chien C, Oh J, Rotstein DL (2021) A window into the future?
What alternative diagnoses have to be considered?
What other biomarkers are of interest?
When to consider NMOSD?

Schema {🗺️}

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      mainEntity:
         headline:Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis
         description:The term ‘neuromyelitis optica spectrum disorders’ (NMOSD) is used as an umbrella term that refers to aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica (NMO) and its formes frustes and to a number of closely related clinical syndromes without AQP4-IgG. NMOSD were originally considered subvariants of multiple sclerosis (MS) but are now widely recognized as disorders in their own right that are distinct from MS with regard to immunopathogenesis, clinical presentation, optimum treatment, and prognosis. In part 1 of this two-part article series, which ties in with our 2014 recommendations, the neuromyelitis optica study group (NEMOS) gives updated recommendations on the diagnosis and differential diagnosis of NMOSD. A key focus is on differentiating NMOSD from MS and from myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD), which shares significant similarity with NMOSD with regard to clinical and, partly, radiological presentation, but is a pathogenetically distinct disease. In part 2, we provide updated recommendations on the treatment of NMOSD, covering all newly approved drugs as well as established treatment options.
         datePublished:2023-04-06T00:00:00Z
         dateModified:2023-04-06T00:00:00Z
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            Neuromyelitis optica spectrum disorders (NMOSD)
            Neuromyelitis optica (NMO)
            Optic neuritis
            Myelitis
            Diagnostic criteria
            Diagnosis
            Differential diagnosis
            MOG antibody-associated encephalomyelitis (MOG-EM)
            MOG antibody-associated disease (MOGAD)
            Magnetic resonance imaging (MRI)
            Serology
            Cerebrospinal fluid (CSF)
            Optic coherence tomography (OCT)
            Clinical presentation
            Aquaporin-4 (AQP4)
            Myelin oligodendrocyte glycoprotein (MOG)
            Autoantibodies
            Neurology
            Neurosciences
            Neuroradiology
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ScholarlyArticle:
      headline:Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis
      description:The term ‘neuromyelitis optica spectrum disorders’ (NMOSD) is used as an umbrella term that refers to aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica (NMO) and its formes frustes and to a number of closely related clinical syndromes without AQP4-IgG. NMOSD were originally considered subvariants of multiple sclerosis (MS) but are now widely recognized as disorders in their own right that are distinct from MS with regard to immunopathogenesis, clinical presentation, optimum treatment, and prognosis. In part 1 of this two-part article series, which ties in with our 2014 recommendations, the neuromyelitis optica study group (NEMOS) gives updated recommendations on the diagnosis and differential diagnosis of NMOSD. A key focus is on differentiating NMOSD from MS and from myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD), which shares significant similarity with NMOSD with regard to clinical and, partly, radiological presentation, but is a pathogenetically distinct disease. In part 2, we provide updated recommendations on the treatment of NMOSD, covering all newly approved drugs as well as established treatment options.
      datePublished:2023-04-06T00:00:00Z
      dateModified:2023-04-06T00:00:00Z
      pageStart:3341
      pageEnd:3368
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s00415-023-11634-0
      keywords:
         Neuromyelitis optica spectrum disorders (NMOSD)
         Neuromyelitis optica (NMO)
         Optic neuritis
         Myelitis
         Diagnostic criteria
         Diagnosis
         Differential diagnosis
         MOG antibody-associated encephalomyelitis (MOG-EM)
         MOG antibody-associated disease (MOGAD)
         Magnetic resonance imaging (MRI)
         Serology
         Cerebrospinal fluid (CSF)
         Optic coherence tomography (OCT)
         Clinical presentation
         Aquaporin-4 (AQP4)
         Myelin oligodendrocyte glycoprotein (MOG)
         Autoantibodies
         Neurology
         Neurosciences
         Neuroradiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00415-023-11634-0/MediaObjects/415_2023_11634_Fig1_HTML.png
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      name:Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany
      name:Department of Neurology, Hannover Medical School, Hannover, Germany

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