
NCBI . NLM . NIH . GOV {
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Title[redir]:
An Iron Regulatory Gene Signature Predicts Outcome in Breast Cancer - PMC
Description:
Changes in iron regulation characterize the malignant state. However, the pathways that effect these changes and their specific impact on prognosis remain poorly understood. We capitalized on publicly available microarray datasets comprising 674 ...
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Keywords {๐}
iron, cancer, irgs, breast, doi, genes, risk, patients, gene, prognostic, expression, high, pubmed, google, scholar, test, cases, low, cohort, dmfs, groups, tumor, pmc, prognosis, regulatory, survival, article, model, table, tumors, data, ferroportin, subtypes, signature, analysis, levels, figure, free, treated, clinical, training, hfe, tamoxifen, hepcidin, supplemental, subtype, significance, tfrc, pathways, metabolism,
Topics {โ๏ธ}
ah-responsive c57bl/10scsn mice multi-institutional โmicroarray meta-cohortโ minimum event-free follow distant metastasis-free survival tfrc-mediated iron uptake brb-arraytools package developed lacking gene names/symbols selective anti-tumour activity surgically-resected frozen tissue variance-covariance structure underlying affect therapeutic decision-making pmc beta search iron-loaded transferrin bound brb-arraytools development team iron regulatory-gene signature transferrin-transferrin receptor system dimethylhydrazine-induced colon carcinogenesis clinico-pathological tumor annotations anti-transferrin receptor antibodies metastasis-free survival gene-expression-based predictors partek genomics suite anti-import phenotypes predicted pro-import phenotypes predicted greatest risk-group stratification favorable survival outcomes full combined cohort publisher site pdf 1=high risk/intermediate risk poor survival outcomes iron efflux pump microarray probe set regulate iron import kaplan-meier plots mediates iron efflux decreased intracellular iron body iron level anti-import phenotype decrease intracellular iron breast cancer outcomes supplementary materials included regulate iron export supervised risk predictor semi-supervised methods iron efflux dyad cancer res abstract pro-import phenotype optimal risk stratification anti-export phenotype bioconductor โaffy package
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