
NCBI . NLM . NIH . GOV {
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Title[redir]:
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin - PMC
Description:
Hypoferremia is a common response to systemic infections or generalized inflammatory disorders. In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the ...
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Keywords {🔍}
hepcidin, iron, mice, doi, mrna, pubmed, google, scholar, human, serum, hours, inflammation, expression, anemia, usa, increased, figure, infusion, mouse, pmc, levels, hypoferremia, cells, abs, lps, diet, response, induction, macrophages, turpentine, fold, blood, article, liver, hepatocytes, urinary, treated, absorption, hepb, compared, humans, increase, decrease, free, inflammatory, hemochromatosis, gene, effects, subjects, transferrin,
Topics {✒️}
interleukin-6/interleukin-6 receptor-alpha complex nih contract n01-dk-9-2310 goat anti-rabbit hrp disulfide-rich peptide produced real-time pcr efficiencies unsaturated iron-binding capacity total iron-binding capacity pmc beta search disulfide-rich antimicrobial peptides pmc copyright notice long-anticipated central regulator methods macrophage culture hepatic acute-phase response real-time rt-pcr anti-human cd68 ab intestinal iron-transporter expression mouse β-actin mrna beta-2-microglobulin knockout mice jackson laboratory–derived breeders anti–tnf-α ab iron-restricted erythropoiesis commonly main iron-consuming tissue strain-matched wt mice tnf-α neutralizing ab publisher site pdf turpentine-induced mouse model high-iron content diet cell-free medium acute-phase cytokines mouse liver-specific gene iron-refed mice compared rapid il-6–induced decrease degradable quenched probe license information pmcid turpentine-treated wt mice markedly increased excretion human hepatocyte culture β-actin expression rapidly induces hypoferremia lps-macrophage–mediated induction mouse β-actin il-6 increases hepcidin macrophage-rich spleen icycler thermal cycler chemiluminescent detection method potentially complex interactions /ml anti_il-6 ab' urinary hepcidin levels hepcidin-1 mrna levels severe iron deficiency
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