We are analyzing https://link.springer.com/chapter/10.1007/978-981-10-3233-2_19.

Title:
Roles of RUNX in Solid Tumors | SpringerLink
Description:
All RUNX genes have been implicated in the development of solid tumors, but the role each RUNX gene plays in the different tumor types is complicated by multiple interactions with major signaling pathways and tumor heterogeneity. Moreover, for a given tissue type,...
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Questions {❓}

1p36 tumor suppression – a matter of dosage?
Runt-related transcription factors in human carcinogenesis: a friend or foe?

Schema {🗺️}

ScholarlyArticle:
      headline:Roles of RUNX in Solid Tumors
      pageEnd:320
      pageStart:299
      image:https://media.springernature.com/w153/springer-static/cover/book/978-981-10-3233-2.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:RUNX Proteins in Development and Cancer
         isbn:
            978-981-10-3233-2
            978-981-10-3231-8
         type:Book
      publisher:
         name:Springer Singapore
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Linda Shyue Huey Chuang
            affiliation:
                  name:National University of Singapore
                  address:
                     name:Cancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kosei Ito
            affiliation:
                  name:Nagasaki University
                  address:
                     name:Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yoshiaki Ito
            affiliation:
                  name:National University of Singapore
                  address:
                     name:Cancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:RUNX, Solid tumors, Tumor suppressor, Oncogene, Wnt, TGFβ, RAS, Senescence, Protein-protein interaction, Stress-inducible gene, Precancerous state, Intestinal metaplasia
      description:All RUNX genes have been implicated in the development of solid tumors, but the role each RUNX gene plays in the different tumor types is complicated by multiple interactions with major signaling pathways and tumor heterogeneity. Moreover, for a given tissue type, the specific role of each RUNX protein is distinct at different stages of differentiation. A regulatory function for RUNX in tissue stem cells points sharply to a causal effect in tumorigenesis. Understanding how RUNX dysregulation in cancer impinges on normal biological processes is important for identifying the molecular mechanisms that lead to malignancy. It will also indicate whether restoration of proper RUNX function to redirect cell fate is a feasible treatment for cancer. With the recent advances in RUNX research, it is time to revisit the many mechanisms/pathways that RUNX engage to regulate cell fate and decide whether cells proliferate, differentiate or die.
      datePublished:2017
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Book:
      name:RUNX Proteins in Development and Cancer
      isbn:
         978-981-10-3233-2
         978-981-10-3231-8
Organization:
      name:Springer Singapore
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National University of Singapore
      address:
         name:Cancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore, Singapore
         type:PostalAddress
      name:Nagasaki University
      address:
         name:Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
         type:PostalAddress
      name:National University of Singapore
      address:
         name:Cancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore, Singapore
         type:PostalAddress
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
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      name:Linda Shyue Huey Chuang
      affiliation:
            name:National University of Singapore
            address:
               name:Cancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore, Singapore
               type:PostalAddress
            type:Organization
      name:Kosei Ito
      affiliation:
            name:Nagasaki University
            address:
               name:Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
               type:PostalAddress
            type:Organization
      name:Yoshiaki Ito
      affiliation:
            name:National University of Singapore
            address:
               name:Cancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore, Singapore
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore, Singapore
      name:Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
      name:Cancer Science Institute of Singapore, Center for Translational Medicine, National University of Singapore, Singapore, Singapore
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