
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer - PMC
Description:
Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here we identify Runx2 as a new regulator of epithelial cell fate in mammary gland development and breast cancer. Runx2 is expressed in the ...
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Keywords {๐}
runx, doi, mammary, cells, cell, cancer, expression, breast, pubmed, google, scholar, epithelial, figure, luminal, pmc, mice, article, differentiation, glands, free, development, pregnancy, gland, cyclin, notch, progenitor, tumor, res, role, survival, model, control, data, fate, populations, progenitors, stem, bone, analysis, alveolar, normal, basal, signaling, performed, epithelium, tumorigenesis, function, transcription, runxffmmtvcre, transplanted,
Topics {โ๏ธ}
mmtv-erbb2/neu/her2 driven tumours promoter-driven cre line linโcd29locd24+cd14+ckitโ/lo pmc beta search anti-apoptotic protein bcl-2 phase-contrast image mask genome-wide transcript analysis promoted cancer cell-invasion mmtv-cre fat pad cre-mediated gene deletion kaplan-meier survival plots mmtv-cre mammary glands beta-casein gene expression er-positive breast cancers mmtv-cre mice result luminal cell-fate commitment runx2/cbfbeta-dependent expression phase-contrast images show cyclin d1-dependent expansion cyclin d1-dependent induction mmtv-pymt mouse model decreased e-cadherin tumor-free survival impaired intranuclear trafficking results developmentally-regulated expression developmental stage-specific regulation hc11-runx2 cells compared cleared fat pads linโcd29locd24+cd14+ckit+ 16 weeks post-transplantation 13 weeks post-transplantation examined ฮฒ-casein expression cd14+ckitโ/lo real-time migration analyses bone-related signals epithelial cell fate mammary epithelial hierarchy hc11 cells stably supplementary materials included alveolar progenitor population runx2-deficient model alveolar progenitor populations hc11 cells induced mammary epithelial cells mammary epithelial populations ethics approvals k00/6-11/3/5545 cell stem cell quantifying cell confluence inducing aberrant proliferation embryonic mammary buds
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- How much does https://doi.org/10.1074/jbc.M603439200 net monthly?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=Cyclin%20D1-cdk4%20induce%20runx2%20ubiquitination%20and%20degradation&author=R%20Shen&author=X%20Wang&author=H%20Drissi&author=F%20Liu&author=RJ%20O%E2%80%99Keefe&volume=281&publication_year=2006&pages=16347-53&pmid=16613857&doi=10.1074/jbc.M603439200&?
- Revenue of https://doi.org/10.1038/nrc3090
- How profitable is https://scholar.google.com/scholar_lookup?journal=Nat%20Rev%20Cancer&title=Cyclin%20D%20as%20a%20therapeutic%20target%20in%20cancer&author=EA%20Musgrove&author=CE%20Caldon&author=J%20Barraclough&author=A%20Stone&author=RL%20Sutherland&volume=11&publication_year=2011&pages=558-72&pmid=21734724&doi=10.1038/nrc3090&?
- What is the monthly revenue of https://doi.org/10.1186/bcr3376?
- https://scholar.google.com/scholar_lookup?journal=Breast%20Cancer%20Res&title=The%20prognostic%20significance%20and%20value%20of%20cyclin%20D1,%20CDK4%20and%20p16%20in%20human%20breast%20cancer&author=E%20Peurala&author=P%20Koivunen&author=KM%20Haapasaari&author=R%20Bloigu&author=A%20Jukkola-Vuorinen&volume=15&publication_year=2013&pages=R5&pmid=23336272&doi=10.1186/bcr3376& income
- Earnings of https://doi.org/10.1007/s10549-013-2563-5
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Breast%20Cancer%20Res%20Treat&title=The%20impact%20of%20cyclin%20D1%20overexpression%20on%20the%20prognosis%20of%20ER-positive%20breast%20cancers:%20a%20meta-analysis&author=XL%20Xu&author=SZ%20Chen&author=W%20Chen&author=WH%20Zheng&author=XH%20Xia&volume=139&publication_year=2013&pages=329-39&pmid=23670132&doi=10.1007/s10549-013-2563-5& bring in?
- What's the revenue for https://doi.org/10.1210/me.2013-1065?
- What's the financial outcome of https://scholar.google.com/scholar_lookup?journal=Mol%20Endocrinol&title=Cyclin%20D1%20determines%20estrogen%20signaling%20in%20the%20mammary%20gland%20in%20vivo&author=MC%20Casimiro&author=C%20Wang&author=Z%20Li&author=G%20Di%20Sante&author=NE%20Willmart&volume=27&publication_year=2013&pages=1415-28&pmid=23864650&doi=10.1210/me.2013-1065&?
- What's https://doi.org/10.1016/j.ccr.2009.11.024's gross income?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=Cyclin%20D1%20kinase%20activity%20is%20required%20for%20the%20self-renewal%20of%20mammary%20stem%20and%20progenitor%20cells%20that%20are%20targets%20of%20MMTV-ErbB2%20tumorigenesis&author=R%20Jeselsohn&author=NE%20Brown&author=L%20Arendt&author=I%20Klebba&author=MG%20Hu&volume=17&publication_year=2010&pages=65-76&pmid=20129248&doi=10.1016/j.ccr.2009.11.024& generate?
- What's the income generated by https://doi.org/10.1158/0008-5472.CAN-13-0409 each month?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Cyclin%20D1-dependent%20induction%20of%20luminal%20inflammatory%20breast%20tumors%20by%20activated%20notch3&author=H%20Ling&author=JR%20Sylvestre&author=P%20Jolicoeur&volume=73&publication_year=2013&pages=5963-73&pmid=23928992&doi=10.1158/0008-5472.CAN-13-0409& each month?
- What's the profit of https://doi.org/10.1152/ajpendo.00666.2011?
- https://scholar.google.com/scholar_lookup?journal=Am%20J%20Physiology%20Endo%20Metab&title=Mammary%20gland%20serotonin%20regulates%20parathyroid%20hormone-related%20protein%20and%20other%20bone-related%20signals&author=LL%20Hernandez&author=KA%20Gregerson&author=ND%20Horseman&volume=302&publication_year=2012&pages=E1009-15&pmid=22318950&doi=10.1152/ajpendo.00666.2011&'s financial summary
- What is the earnings of https://doi.org/10.1038/onc.2012.452?
- How much profit is https://scholar.google.com/scholar_lookup?journal=Oncogene&title=Multipotent%20PI-MECs%20are%20the%20true%20targets%20of%20MMTV-neu%20tumorigenesis&author=KU%20Wagner&author=BW%20Booth&author=CA%20Boulanger&author=GH%20Smith&volume=32&publication_year=2013&pages=1338&pmid=23045277&doi=10.1038/onc.2012.452& making per month?
- Explore the financials of https://doi.org/10.1038/nm.2000
- How much does https://scholar.google.com/scholar_lookup?journal=Nat%20Med&title=Aberrant%20luminal%20progenitors%20as%20the%20candidate%20target%20population%20for%20basal%20tumor%20development%20in%20BRCA1%20mutation%20carriers&author=E%20Lim&author=F%20Vaillant&author=D%20Wu&author=NC%20Forrest&author=B%20Pal&volume=15&publication_year=2009&pages=907-13&pmid=19648928&doi=10.1038/nm.2000& earn?
- How much does https://doi.org/10.1158/0008-5472.CAN-13-1351 make?
- Profit of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Distinct%20FAK%20activities%20determine%20progenitor%20and%20mammary%20stem%20cell%20characteristics&author=M%20Luo&author=X%20Zhao&author=S%20Chen&author=S%20Liu&author=MS%20Wicha&volume=73&publication_year=2013&pages=5591-602&pmid=23832665&doi=10.1158/0008-5472.CAN-13-1351&
- How much does https://github.com/ncbi make?
- How much revenue does https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323 generate?
- How much profit does https://www.nlm.nih.gov/web_policies.html make?
- How much does https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office make?
- How much does https://www.hhs.gov/vulnerability-disclosure-policy/index.html earn?
- Profit of https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Amanuscript
- How much profit does https://www.nlm.nih.gov/accessibility.html generate?
- What's the financial outcome of https://www.nlm.nih.gov/careers/careers.html?
- https://www.nlm.nih.gov/ income
- How much profit does https://www.nih.gov/ make?
- What's the total monthly financial gain of https://www.hhs.gov/?
- What's the income of https://www.usa.gov/?
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