We are analyzing https://link.springer.com/article/10.1007/s12307-014-0147-5.

Title:
The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment | Cancer Microenvironment
Description:
Neutrophils are myeloid cells that constitute 50–70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.
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Keywords {🔍}

pubmed, google, scholar, article, cas, cancer, central, tumor, cells, neutrophils, cell, factor, immunol, res, human, neutrophil, growth, carcinoma, patients, oncol, ratio, wang, expression, clin, role, int, colonystimulating, immune, med, granulocyte, chen, doican, dois, van, metastasis, zhang, blood, progression, prognostic, granulocytes, receptor, liu, cytotoxicity, exp, angiogenesis, lung, endothelial, surg, colorectal, myeloid,

Topics {✒️}

granulocyte-colony-stimulating factor-producing tumor granulocyte-macrophage colony-stimulating factor granulocyte-macrophage-colony-stimulating factor granulocyte-colony-stimulating factor administration g-csf-producing soft-tissue tumors g-csf-granulocytic mdsc axis granulocyte colony-stimulating factor granulocyte-colony-stimulating factor granulocyte-colony stimulating factor rifn-gamma-activated rat neutrophils macrophage colony-stimulating factor epithelial-cell-derived neutrophil attractant-78 bone-marrow-derived endothelial cd8-positive t-cell ratio hydrogen peroxide-myeloperoxidase-chloride system month download article/chapter transforming growth factor-beta1 long-lasting anti-tumor immunity myeloid-derived suppressor cells endothelial cell-derived chemokines cell-mediated anti-tumor immunity polymorphonuclear leukocyte-derived factor tumor necrosis factor-alpha nf-kappab/hdac1 epigenetic regulation granulocyte-derived hydrogen peroxide g-csf stimulates angiogenesis hypoxia-induced lysyl oxidase tumor-inhibitory mrc-ox8+ tgf-beta-driven synovial inflammation autocrine survival-growth factor polymorphonuclear leukocyte-derived calprotectin cools-lartigue jj myeloperoxidase-h2o2-halide system t-cell-mediated cytotoxicity cyclic amp-elevating agents biological antitumor activity cd20-directed antibody therapy il-1beta-induced peritonitis oncogenic ras-induced expression pre-operative elevated neutrophil neutrophil-based antitumour treatment facilitate breast-tumour metastasis small-cell lung cancer cd11/cd18 adhesion molecules peroxidase-h2o2-halide system intratumoral cd66b-positive neutrophil cxc chemokine-mediated angiogenesis tumor necrosis factor lps-induced pmn trafficking vegf-induced adult neovascularization

Questions {❓}

Chan AT, Cook NR (2012) Are we ready to recommend aspirin for cancer prevention?
Demirtas A, Sabur V, Akinsal EC, Demirci D, Ekmekcioglu O, Gulmez I, Tatlisen A (2013) Can neutrophil-lymphocyte ratio and lymph node density be used as prognostic factors in patients undergoing radical cystectomy?
Fridlender ZG, Albelda SM (2012) Tumor-associated neutrophils: friend or foe?
Whalen GF (1990) Solid tumours and wounds: transformed cells misunderstood as injured tissue?
Wilke CM, Kryczek I, Wei S, Zhao E, Wu K, Wang G, Zou W (2011) Th17 cells in cancer: help or hindrance?

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