We are analyzing https://link.springer.com/article/10.1007/s00395-015-0520-7.

Title:
Emerging role of liver X receptors in cardiac pathophysiology and heart failure | Basic Research in Cardiology
Description:
Liver X receptors (LXRs) are master regulators of metabolism and have been studied for their pharmacological potential in vascular and metabolic disease. Besides their established role in metabolic homeostasis and disease, there is mounting evidence to suggest that LXRs may exert direct beneficial effects in the heart. Here, we aim to provide a conceptual framework to explain the broad mode of action of LXRs and how LXR signaling may be an important local and systemic target for the treatment of heart failure. We discuss the potential role of LXRs in systemic conditions associated with heart failure, such as hypertension, diabetes, and renal and vascular disease. Further, we expound on recent data that implicate a direct role for LXR activation in the heart, for its impact on cardiomyocyte damage and loss due to ischemia, and effects on cardiac hypertrophy, fibrosis, and myocardial metabolism. Taken together, the accumulating evidence supports the notion that LXRs may represent a novel therapeutic target for the treatment of heart failure.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, google, scholar, cas, heart, lxr, liver, lxrs, receptor, failure, activation, cardiac, central, myocardial, lxrα, glucose, diabetes, mice, disease, effects, signaling, receptors, role, remodeling, cell, metabolic, cholesterol, expression, gene, insulin, pii, metabolism, agonist, van, vascular, lipid, dysfunction, increased, atherosclerosis, hypertrophy, target, cells, chronic, growth, function, injury, endothelial, biol, wang,

Topics {✒️}

lxrα/β-deficient ob/ob mice prevented hypoxia-reoxygenation-induced apoptosis bsp/cpd/e-pub/000724 [pii] cardiac renin-angiotensin-aldosterone system carbohydrate-response element-binding protein suppressing nf-kappab signalling thyroid hormone-responsive elements article download pdf renin-angiotensin-aldosterone system n-dimethyl-3β-hydroxycholenamide liver-x-receptor beta protects entero-hepatic sterol absorption renin-angiotensin system antagonists amp-activated protein kinase insulin-stimulated as160 phosphorylation high-fat fed rats counteract pro-fibrotic signaling receptor-alpha reduces activation potent anti-hypertrophic effectors multi-organ dysfunction involving extracellular matrix turnover keap-1/nrf-2 signaling pathways streptozotocin-induced diabetic rats β-cell insulin secretion lxrα-encoding gene nr1h3 downstream posttranslational o-glcnacylation infarct-sparing effects occurred db/db diabetic mouse oxidized low-density lipoprotein pro-fibrotic gene expression hyperglycemia-induced renal damage tac-induced pressure overload macrophage-derived lxr signaling at1 receptor-dependent activation glucose-activated transcription factor exerts anti-fibrotic effects hyperglycemic-induced kidney disease camp-responsive transcriptional regulator mitochondria-mediated apoptotic pathways aibp-mediated cholesterol efflux ligand-activated transcription factors liver x-receptor agonist liver-x-receptor alpha lxr-dependent gene expression lxr-null mice lost anti-apoptotic factor aim liver-x-receptor ligand post-ischemic myocardial apoptosis adrenergic-fatty acid load lxr/rxr complex undergoes

Questions {❓}

Rankinen T, Sarzynski MA, Ghosh S, Bouchard C (2015) Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors?
Viennois E, Pommier AJ, Mouzat K, Oumeddour A, El Hajjaji FZ, Dufour J, Caira F, Volle DH, Baron S, Lobaccaro JM (2011) Targeting liver X receptors in human health: deadlock or promising trail?

Schema {🗺️}

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         description:Liver X receptors (LXRs) are master regulators of metabolism and have been studied for their pharmacological potential in vascular and metabolic disease. Besides their established role in metabolic homeostasis and disease, there is mounting evidence to suggest that LXRs may exert direct beneficial effects in the heart. Here, we aim to provide a conceptual framework to explain the broad mode of action of LXRs and how LXR signaling may be an important local and systemic target for the treatment of heart failure. We discuss the potential role of LXRs in systemic conditions associated with heart failure, such as hypertension, diabetes, and renal and vascular disease. Further, we expound on recent data that implicate a direct role for LXR activation in the heart, for its impact on cardiomyocyte damage and loss due to ischemia, and effects on cardiac hypertrophy, fibrosis, and myocardial metabolism. Taken together, the accumulating evidence supports the notion that LXRs may represent a novel therapeutic target for the treatment of heart failure.
         datePublished:2015-11-26T00:00:00Z
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            Liver X receptors
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      headline:Emerging role of liver X receptors in cardiac pathophysiology and heart failure
      description:Liver X receptors (LXRs) are master regulators of metabolism and have been studied for their pharmacological potential in vascular and metabolic disease. Besides their established role in metabolic homeostasis and disease, there is mounting evidence to suggest that LXRs may exert direct beneficial effects in the heart. Here, we aim to provide a conceptual framework to explain the broad mode of action of LXRs and how LXR signaling may be an important local and systemic target for the treatment of heart failure. We discuss the potential role of LXRs in systemic conditions associated with heart failure, such as hypertension, diabetes, and renal and vascular disease. Further, we expound on recent data that implicate a direct role for LXR activation in the heart, for its impact on cardiomyocyte damage and loss due to ischemia, and effects on cardiac hypertrophy, fibrosis, and myocardial metabolism. Taken together, the accumulating evidence supports the notion that LXRs may represent a novel therapeutic target for the treatment of heart failure.
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         Cardiovascular risk factors
         Heart failure
         Hypertrophy
         Liver X receptors
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         Cardiology
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