
NCBI . NLM . NIH . GOV {
}
Title[redir]:
LXR as a novel antithrombotic target - PMC
Description:
Liver X receptors (LXRs) are transcription factors involved in the regulation of cholesterol homeostasis. LXR ligands have athero-protective properties independent of their effects on cholesterol metabolism. Platelets are involved in the initiation ...
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Keywords {🔍}
doi, platelets, platelet, lxr, figure, pubmed, google, scholar, collagen, aggregation, ligands, receptor, cholesterol, effects, stimulated, lxrβ, data, μgml, phosphorylation, blood, receptors, mice, concentrations, pmc, article, activation, levels, tyrosine, thrombus, syk, signaling, gpvi, atherosclerosis, thrombin, nuclear, human, function, secretion, thrombi, antibodies, free, liver, role, pparγ, antibody, dmso, potential, shown, plcγ, biol,
Topics {✒️}
low-density lipoprotein-lowering medications alexa-488-conjugated anti-gpib antibody alexa488-conjugated anti-gpib antibody anti-gpib alexafluor-488-labeled antibody peroxisome proliferator-activated receptor-γ pe/cy5 antihuman-cd62p lxr-β/ppar-γ dimers pmc beta search fc receptor gamma-chain cy3-labeled secondary antibody fluorescein isothiocyanate-labeled fibrinogen fluorescent dye fluo-4nw von willebrand factor page charge payment modified tyrode-n-2-hydroxyethylpiperazine luciferin-luciferase system kit inhibit α-granule secretion calcium-dependent functions occurring primary anti-lxr-β fluo-4nw-loaded platelets reduced dense-granule secretion lxr-β-ppar-γ interactions lxr-β-selective ligands glyceraldehyde-3-phosphate dehydrogenase levels 15 low-density lipoprotein lxr-activating oxysterols induce liver-x-receptor-specific inhibition athero-protective properties independent specific phosphorylation site ppar-γ/lxr dimers apoai-dependent efflux stimulated blood web site anti-lxr-β antibodies laser-induced tissue injury collagen-induced tyrosine phosphorylation platelet α-granule secretion half-maximal fluorescence values lxr-dependent pathways distinct supplementary materials included anti-atherogenic activity measure p-selectin exposure anti-cd62p antibody lxr-β-specific receptors thrombin-induced aggregation compared gpvi-induced calcium mobilization dense granule secretion high-density lipoproteins tab lxr-β gw3965-treated thrombi occupied athero-protective effects possibly
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