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We began analyzing https://www.nature.com/articles/pr20109, but it redirected us to https://www.nature.com/articles/pr20109. The analysis below is for the second page.

Title[redir]:
Gestational Protein Restriction in Mice Has Pronounced Effects on Gene Expression in Newborn Offspring's Liver and Skeletal Muscle; Protective Effect of Taurine | Pediatric Research
Description:
We examined gene expression changes in liver and skeletal muscle of newborn mice subjected to a maternal low protein (LP) or normal protein (NP) diet during pregnancy, with or without taurine supplementation in the drinking water. LP offspring had a 40% lower birthweight than NP offspring, whereas it was reduced by only 20% with taurine supplementation. Microarray gene expression analysis revealed significant changes in 2012 genes in liver and 967 genes in skeletal muscle of LP offspring. By unknown mechanisms, taurine partially or fully prevented 30 and 46% of these expression changes, respectively. Mitochondrial genes, in particular genes associated with oxidative phosphorylation, were more abundantly changed in LP offspring, with primarily up-regulation in liver but down-regulation in skeletal muscle. In both tissues, citrate synthase activity remained unchanged. Taurine preferentially rescued changes in genes concerned with fatty acid metabolism in liver and with oxidative phoshorylation and tri carboxylic acid (TCA) cycle in skeletal muscle. Conclusion: Gestational protein restriction resulted in lower birthweight associated with significant gene expression changes, which was different in liver and muscle of offspring. However, a major part of the birthweight decrease and the expression changes were prevented by maternal taurine supplementation, implying taurine is a key component in metabolic fetal programming.

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Keywords {🔍}

taurine, muscle, skeletal, liver, article, genes, diet, google, scholar, expression, cas, mitochondrial, maternal, gene, protein, mice, table, effect, offspring, insulin, supplementation, oxidative, newborn, low, nature, phosphorylation, fetal, changed, decrease, birth, diabetes, effects, weight, function, birthweight, acid, involved, content, metabolism, difference, rats, pregnancy, resistance, tau, fig, httplinkslwwcompdra, rat, research, water, development,

Topics {✒️}

nature portfolio permissions reprints privacy policy nature advertising danish research council social media strategic research 2101-05-0030 full size image peter eigil nielsen hanne lodberg olsen pgc-1beta gene expression laboratory animal science intrauterine growth-retarded rats maternal low-protein diet rat embryo-fetal axis finn cilius nielsen impaired insulin signaling permissions microarray data martin-gronert ms intrauterine growth retardation european economic area tri carboxylic acid maternal low protein mitochondrial dna content gestational protein restriction growth-retarded rats supplemental digital content osmotic pressure regulation dexamethasone induced atrophy normal fetal development insulin resistance induced taurine transporter knockout hepatic glucose production low protein diet ozanne se direct url citations significant gene expression gene expression levels privacy improving glucose homeostasis hepatic mitochondrial compartment hepatic insulin resistance specific enzyme activity personal data neonatal exposure selak ma enter protein synthesis metabolic fetal programming

Questions {❓}

Bouckenooghe T, Remacle C, Reusens B 2006 Is taurine a functional nutrient?
Luo ZC, Fraser WD, Julien P, Deal CL, Audibert F, Smith GN, Xiong X, Walker M 2006 Tracing the origins of “fetal origins” of adult diseases: programming by oxidative stress?
Ozanne SE, Jensen CB, Tingey KJ, Martin-Gronert MS, Grunnet L, Brons C, Storgaard H, Vaag AA 2006 Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: potential link to increased risk of diabetes?
De Boo HA, Harding JE 2007 Taurine as a marker for foetal wellbeing?

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