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We are analyzing https://link.springer.com/article/10.1007/s00125-002-0833-6.

Title:
Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets | Diabetologia
Description:
Aims/hypothesis. In our previous studies a low protein diet (8% vs 20%) given during foetal and early postnatal life induced abnormal development of the endocrine pancreas; beta-cell mass and islet-cell proliferation were reduced while apoptosis was increased. Taurine, an important amino acid for development was also reduced in maternal and foetal plasma of protein deficient animals. In this study we aim to evaluate the role of taurine in the alterations observed in rats after a low protein diet. Methods. Four groups of rats were given either a control, a low protein, or control and low protein diets with 2.5% taurine in the drinking water. Diets were given to gestating and lactating mothers and to their pups until day 30. Beta and endocrine cell masses were analysed as well as DNA synthesis and apoptosis after taurine supplementation in foetuses and pups. We also investigated insulin like growth factor-II (IGF-II), inducible nitric oxide synthase (iNOS), and Fas by immunohistochemistry. Results. In foetuses and neonates nourished with a low protein diet, taurine supplementation restored normal DNA synthesis and apoptosis. This led to adequate beta and endocrine cell mass in pups. In islet cells, immunoreactivity was increased for IGF-II, reduced for Fas and unchanged for iNOS after taurine supplementation. Conclusion/interpretation. Taurine supplementation to a low protein diet in foetal and early postnatal life prevents the abnormal development of the endocrine pancreas. The mechanisms by which taurine acts on DNA synthesis and apoptosis rate of endocrine cells involve IGF-II, Fas regulation but not iNOS.
Website Age:
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Keywords {πŸ”}

taurine, protein, low, article, supplementation, diet, endocrine, apoptosis, privacy, cookies, foetal, development, content, information, publish, research, search, early, postnatal, life, igfii, fas, data, journal, diabetologia, normal, proliferation, rat, pancreatic, islets, download, boujendar, reusens, merezak, pancreas, reduced, rats, pups, dna, synthesis, inos, discover, health, ontario, function, optional, personal, parties, policy, find,

Topics {βœ’οΈ}

rat pancreatic islets low protein diet related subjects privacy choices/manage cookies growth factor-ii endocrine cell masses endocrine cell mass igf-ii low protein diets protein deficient animals dietary protein modulates main content log european economic area important amino acid abnormal development conditions privacy policy ontario n6a 4v2 accepting optional cookies low protein scope submit manuscript beta-cell mass islet-cell proliferation louvain-la-neuve search search adaptive islet function journal finder publish endocrine pancreas taurine supplementation dna synthesis article cite fas regulation article boujendar islet cells privacy policy normal proliferation personal data health care books a taurine acts rats optional cookies information manage preferences development diabetologia 45 data protection essential cookies cookies skip maternal fas

Schema {πŸ—ΊοΈ}

WebPage:
      mainEntity:
         headline:Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets
         description: Aims/hypothesis. In our previous studies a low protein diet (8% vs 20%) given during foetal and early postnatal life induced abnormal development of the endocrine pancreas; beta-cell mass and islet-cell proliferation were reduced while apoptosis was increased. Taurine, an important amino acid for development was also reduced in maternal and foetal plasma of protein deficient animals. In this study we aim to evaluate the role of taurine in the alterations observed in rats after a low protein diet. Methods. Four groups of rats were given either a control, a low protein, or control and low protein diets with 2.5% taurine in the drinking water. Diets were given to gestating and lactating mothers and to their pups until day 30. Beta and endocrine cell masses were analysed as well as DNA synthesis and apoptosis after taurine supplementation in foetuses and pups. We also investigated insulin like growth factor-II (IGF-II), inducible nitric oxide synthase (iNOS), and Fas by immunohistochemistry. Results. In foetuses and neonates nourished with a low protein diet, taurine supplementation restored normal DNA synthesis and apoptosis. This led to adequate beta and endocrine cell mass in pups. In islet cells, immunoreactivity was increased for IGF-II, reduced for Fas and unchanged for iNOS after taurine supplementation. Conclusion/interpretation. Taurine supplementation to a low protein diet in foetal and early postnatal life prevents the abnormal development of the endocrine pancreas. The mechanisms by which taurine acts on DNA synthesis and apoptosis rate of endocrine cells involve IGF-II, Fas regulation but not iNOS.
         datePublished:2002-05-08T00:00:00Z
         dateModified:2002-05-08T00:00:00Z
         pageStart:856
         pageEnd:866
         sameAs:https://doi.org/10.1007/s00125-002-0833-6
         keywords:
            Rats development low protein diet taurine pancreatic islets BrdU TUNEL IGF-II Fas
            Internal Medicine
            Metabolic Diseases
            Human Physiology
         image:
         isPartOf:
            name:Diabetologia
            issn:
               1432-0428
               0012-186X
            volumeNumber:45
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:S. Boujendar
               affiliation:
                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                     address:
                        name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
                        type:PostalAddress
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               type:Person
               name:B. Reusens
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                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                     address:
                        name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
                        type:PostalAddress
                     type:Organization
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               name:S. Merezak
               affiliation:
                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                     address:
                        name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
                        type:PostalAddress
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               name:M.-T. Ahn
               affiliation:
                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                     address:
                        name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
                        type:PostalAddress
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               type:Person
               name:E. Arany
               affiliation:
                     name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2
                     address:
                        name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:D. Hill
               affiliation:
                     name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2
                     address:
                        name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:C. Remacle
               affiliation:
                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                     address:
                        name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets
      description: Aims/hypothesis. In our previous studies a low protein diet (8% vs 20%) given during foetal and early postnatal life induced abnormal development of the endocrine pancreas; beta-cell mass and islet-cell proliferation were reduced while apoptosis was increased. Taurine, an important amino acid for development was also reduced in maternal and foetal plasma of protein deficient animals. In this study we aim to evaluate the role of taurine in the alterations observed in rats after a low protein diet. Methods. Four groups of rats were given either a control, a low protein, or control and low protein diets with 2.5% taurine in the drinking water. Diets were given to gestating and lactating mothers and to their pups until day 30. Beta and endocrine cell masses were analysed as well as DNA synthesis and apoptosis after taurine supplementation in foetuses and pups. We also investigated insulin like growth factor-II (IGF-II), inducible nitric oxide synthase (iNOS), and Fas by immunohistochemistry. Results. In foetuses and neonates nourished with a low protein diet, taurine supplementation restored normal DNA synthesis and apoptosis. This led to adequate beta and endocrine cell mass in pups. In islet cells, immunoreactivity was increased for IGF-II, reduced for Fas and unchanged for iNOS after taurine supplementation. Conclusion/interpretation. Taurine supplementation to a low protein diet in foetal and early postnatal life prevents the abnormal development of the endocrine pancreas. The mechanisms by which taurine acts on DNA synthesis and apoptosis rate of endocrine cells involve IGF-II, Fas regulation but not iNOS.
      datePublished:2002-05-08T00:00:00Z
      dateModified:2002-05-08T00:00:00Z
      pageStart:856
      pageEnd:866
      sameAs:https://doi.org/10.1007/s00125-002-0833-6
      keywords:
         Rats development low protein diet taurine pancreatic islets BrdU TUNEL IGF-II Fas
         Internal Medicine
         Metabolic Diseases
         Human Physiology
      image:
      isPartOf:
         name:Diabetologia
         issn:
            1432-0428
            0012-186X
         volumeNumber:45
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:S. Boujendar
            affiliation:
                  name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                  address:
                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:B. Reusens
            affiliation:
                  name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                  address:
                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:S. Merezak
            affiliation:
                  name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                  address:
                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M.-T. Ahn
            affiliation:
                  name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                  address:
                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:E. Arany
            affiliation:
                  name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2
                  address:
                     name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
                     type:PostalAddress
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            type:Person
            name:D. Hill
            affiliation:
                  name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2
                  address:
                     name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
                     type:PostalAddress
                  type:Organization
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            name:C. Remacle
            affiliation:
                  name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
                  address:
                     name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
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      name:Springer-Verlag
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         name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
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      name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2
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         name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
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      name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2
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         name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
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      name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
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         name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
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      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:S. Boujendar
      affiliation:
            name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
            address:
               name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
      name:B. Reusens
      affiliation:
            name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
            address:
               name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
      name:S. Merezak
      affiliation:
            name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
            address:
               name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
      name:M.-T. Ahn
      affiliation:
            name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
            address:
               name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
      name:E. Arany
      affiliation:
            name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2
            address:
               name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
               type:PostalAddress
            type:Organization
      name:D. Hill
      affiliation:
            name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2
            address:
               name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
               type:PostalAddress
            type:Organization
      name:C. Remacle
      affiliation:
            name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve
            address:
               name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
      name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
      name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
      name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium
      name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
      name:Lawson Health Research Institute, St. Joseph's Health Care, London Ontario; and Departments of Medicine, Physiology and Paediatrics, University of Western Ontario, Ontario N6A 4V2, Canada
      name:Laboratory of Cellular Biology, World Health Collaborating Center for the Development of the Endocrine Pancreas, Catholic University of Louvain, Louvain-la-Neuve, Belgium

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