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We are analyzing https://link.springer.com/article/10.1007/s00125-008-0956-5.

Title:
The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation | Diabetologia
Description:
Aims/hypothesis Events during fetal life may in critical time windows programme tissue development leading to organ dysfunction with potentially harmful consequences in adulthood such as diabetes. In rats, the beta cell mass of progeny from dams fed with a low-protein (LP) diet during gestation is decreased at birth and metabolic perturbation lasts through adulthood even though a normal diet is given after birth or after weaning. Maternal and fetal plasma taurine levels are suboptimal. Maternal taurine supplementation prevents these induced abnormalities. In this study, we aimed to reveal changes in gene expression in fetal islets affected by the LP diet and how taurine may prevent these changes. Methods Pregnant Wistar rats were fed an LP diet (8% [wt/wt] protein) supplemented or not with taurine in the drinking water or a control diet (20% [wt/wt] protein). At 21.5 days of gestation, fetal pancreases were removed, digested and cultured for 7 days. Neoformed islets were collected and transcriptome analysis was performed. Results Maternal LP diet significantly changed the expression of more than 10% of the genes. Tricarboxylic acid cycle and ATP production were highly targeted, but so too were cell proliferation and defence. Maternal taurine supplementation normalised the expression of all altered genes. Conclusions/interpretation Development of the beta cells and particularly their respiration is modulated by the intrauterine environment, which may epigenetically modify expression of the genome and programme the beta cell towards a pre-diabetic phenotype. This mis-programming by maternal LP diet was prevented by early taurine intervention.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

diet, islets, taurine, maternal, expression, fetal, genes, cell, google, scholar, pubmed, article, cas, gene, beta, protein, diabetes, control, glucose, mitochondrial, reusens, significantly, involved, analysis, development, table, rat, supplementation, rats, atp, increased, lpt, low, remacle, changed, insulin, cycle, islet, igf, identified, fig, content, diabetologia, rna, data, fed, gestation, proliferation, altered, cells,

Topics {✒️}

uk/srsbin/cgi-bin/wgetz background-corrected probe values long-term consequences b60–b69 el-khattabi hot-start dna polymerase cmd=search&db=pubmed ucp2-overexpressing b-cells confocal laser-scanning microscope /cgi-bin/source/sourcesearch igf gene/protein family gov/projects/genome/genemap99/ low-protein diet supplemented fetal insulin-secreting cell inadequate maternal nutrition impaired glucose homeostasis beta cell mass beta-cell mass maternal low-protein related subjects high-fat diet early postnatal malnutrition low protein diet quantitative rt-pcr privacy choices/manage cookies transcriptome analysis fetal beta cell maternal protein restriction early taurine intervention remove probe sets gestational protein restriction low lactate dehydrogenase maternal lp diet pre-diabetic phenotype low-energy diet gestational diabetes leads glyceraldehyde-3-phosphate dehydrogenase beta cell maturation maternal lp targeted il-1beta sensitivity electronic supplementary material maternal diet manipulation fetal wistar rats beta cell development fat-rich diet protein restricted diet thrifty phenotype hypothesis peripheral insulin signalling superscript ii system raw image files rt-pcr analyses

Questions {❓}

  • One question that remains is: is the altered phenotype that we observed the consequence of few modifications of gene expression leading to many beta cell secondary effects, or does it result from induction of a wide network of relatively minor imbalances?
  • Uk/srsbin/cgi-bin/wgetz?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation
         description:Events during fetal life may in critical time windows programme tissue development leading to organ dysfunction with potentially harmful consequences in adulthood such as diabetes. In rats, the beta cell mass of progeny from dams fed with a low-protein (LP) diet during gestation is decreased at birth and metabolic perturbation lasts through adulthood even though a normal diet is given after birth or after weaning. Maternal and fetal plasma taurine levels are suboptimal. Maternal taurine supplementation prevents these induced abnormalities. In this study, we aimed to reveal changes in gene expression in fetal islets affected by the LP diet and how taurine may prevent these changes. Pregnant Wistar rats were fed an LP diet (8% [wt/wt] protein) supplemented or not with taurine in the drinking water or a control diet (20% [wt/wt] protein). At 21.5 days of gestation, fetal pancreases were removed, digested and cultured for 7 days. Neoformed islets were collected and transcriptome analysis was performed. Maternal LP diet significantly changed the expression of more than 10% of the genes. Tricarboxylic acid cycle and ATP production were highly targeted, but so too were cell proliferation and defence. Maternal taurine supplementation normalised the expression of all altered genes. Development of the beta cells and particularly their respiration is modulated by the intrauterine environment, which may epigenetically modify expression of the genome and programme the beta cell towards a pre-diabetic phenotype. This mis-programming by maternal LP diet was prevented by early taurine intervention.
         datePublished:2008-03-03T00:00:00Z
         dateModified:2008-03-03T00:00:00Z
         pageStart:836
         pageEnd:845
         sameAs:https://doi.org/10.1007/s00125-008-0956-5
         keywords:
            Diabetes
            Early programming
            Fetal islets
            Maternal low-protein diet
            Rats
            Taurine
            Transcriptome
            Internal Medicine
            Metabolic Diseases
            Human Physiology
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            issn:
               1432-0428
               0012-186X
            volumeNumber:51
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               name:B. Reusens
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                     name:Université catholique de Louvain
                     address:
                        name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
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                     name:Université catholique de Louvain
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                     name:Université catholique de Louvain
                     address:
                        name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
                        type:PostalAddress
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                     name:Université catholique de Louvain
                     address:
                        name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
                        type:PostalAddress
                     type:Organization
               type:Person
               name:M. Kruhøffer
               affiliation:
                     name:Aarhus University Hospital Skejby
                     address:
                        name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
                        type:PostalAddress
                     type:Organization
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               name:T. F. Ørntoft
               affiliation:
                     name:Aarhus University Hospital Skejby
                     address:
                        name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
                        type:PostalAddress
                     type:Organization
               type:Person
               name:J. Nerup
               affiliation:
                     name:Steno Diabetes Center
                     address:
                        name:Steno Diabetes Center, Gentofte, Denmark
                        type:PostalAddress
                     type:Organization
                     name:University of Lund
                     address:
                        name:Department of Clinical Science, University of Lund, Lund, Sweden
                        type:PostalAddress
                     type:Organization
               type:Person
               name:C. Remacle
               affiliation:
                     name:Université catholique de Louvain
                     address:
                        name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
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ScholarlyArticle:
      headline:The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation
      description:Events during fetal life may in critical time windows programme tissue development leading to organ dysfunction with potentially harmful consequences in adulthood such as diabetes. In rats, the beta cell mass of progeny from dams fed with a low-protein (LP) diet during gestation is decreased at birth and metabolic perturbation lasts through adulthood even though a normal diet is given after birth or after weaning. Maternal and fetal plasma taurine levels are suboptimal. Maternal taurine supplementation prevents these induced abnormalities. In this study, we aimed to reveal changes in gene expression in fetal islets affected by the LP diet and how taurine may prevent these changes. Pregnant Wistar rats were fed an LP diet (8% [wt/wt] protein) supplemented or not with taurine in the drinking water or a control diet (20% [wt/wt] protein). At 21.5 days of gestation, fetal pancreases were removed, digested and cultured for 7 days. Neoformed islets were collected and transcriptome analysis was performed. Maternal LP diet significantly changed the expression of more than 10% of the genes. Tricarboxylic acid cycle and ATP production were highly targeted, but so too were cell proliferation and defence. Maternal taurine supplementation normalised the expression of all altered genes. Development of the beta cells and particularly their respiration is modulated by the intrauterine environment, which may epigenetically modify expression of the genome and programme the beta cell towards a pre-diabetic phenotype. This mis-programming by maternal LP diet was prevented by early taurine intervention.
      datePublished:2008-03-03T00:00:00Z
      dateModified:2008-03-03T00:00:00Z
      pageStart:836
      pageEnd:845
      sameAs:https://doi.org/10.1007/s00125-008-0956-5
      keywords:
         Diabetes
         Early programming
         Fetal islets
         Maternal low-protein diet
         Rats
         Taurine
         Transcriptome
         Internal Medicine
         Metabolic Diseases
         Human Physiology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-008-0956-5/MediaObjects/125_2008_956_Fig1_HTML.gif
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      isPartOf:
         name:Diabetologia
         issn:
            1432-0428
            0012-186X
         volumeNumber:51
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:B. Reusens
            affiliation:
                  name:Université catholique de Louvain
                  address:
                     name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:T. Sparre
            affiliation:
                  name:Steno Diabetes Center
                  address:
                     name:Steno Diabetes Center, Gentofte, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:L. Kalbe
            affiliation:
                  name:Université catholique de Louvain
                  address:
                     name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
                     type:PostalAddress
                  type:Organization
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            name:T. Bouckenooghe
            affiliation:
                  name:Université catholique de Louvain
                  address:
                     name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:N. Theys
            affiliation:
                  name:Université catholique de Louvain
                  address:
                     name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
                     type:PostalAddress
                  type:Organization
            type:Person
            name:M. Kruhøffer
            affiliation:
                  name:Aarhus University Hospital Skejby
                  address:
                     name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:T. F. Ørntoft
            affiliation:
                  name:Aarhus University Hospital Skejby
                  address:
                     name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
                     type:PostalAddress
                  type:Organization
            type:Person
            name:J. Nerup
            affiliation:
                  name:Steno Diabetes Center
                  address:
                     name:Steno Diabetes Center, Gentofte, Denmark
                     type:PostalAddress
                  type:Organization
                  name:University of Lund
                  address:
                     name:Department of Clinical Science, University of Lund, Lund, Sweden
                     type:PostalAddress
                  type:Organization
            type:Person
            name:C. Remacle
            affiliation:
                  name:Université catholique de Louvain
                  address:
                     name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
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      name:Diabetologia
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      name:Université catholique de Louvain
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      name:Steno Diabetes Center
      address:
         name:Steno Diabetes Center, Gentofte, Denmark
         type:PostalAddress
      name:Université catholique de Louvain
      address:
         name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
         type:PostalAddress
      name:Université catholique de Louvain
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         type:PostalAddress
      name:Université catholique de Louvain
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         name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
         type:PostalAddress
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      address:
         name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
         type:PostalAddress
      name:Aarhus University Hospital Skejby
      address:
         name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
         type:PostalAddress
      name:Steno Diabetes Center
      address:
         name:Steno Diabetes Center, Gentofte, Denmark
         type:PostalAddress
      name:University of Lund
      address:
         name:Department of Clinical Science, University of Lund, Lund, Sweden
         type:PostalAddress
      name:Université catholique de Louvain
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            name:Université catholique de Louvain
            address:
               name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:T. Sparre
      affiliation:
            name:Steno Diabetes Center
            address:
               name:Steno Diabetes Center, Gentofte, Denmark
               type:PostalAddress
            type:Organization
      name:L. Kalbe
      affiliation:
            name:Université catholique de Louvain
            address:
               name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
      name:T. Bouckenooghe
      affiliation:
            name:Université catholique de Louvain
            address:
               name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
      name:N. Theys
      affiliation:
            name:Université catholique de Louvain
            address:
               name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
      name:M. Kruhøffer
      affiliation:
            name:Aarhus University Hospital Skejby
            address:
               name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
               type:PostalAddress
            type:Organization
      name:T. F. Ørntoft
      affiliation:
            name:Aarhus University Hospital Skejby
            address:
               name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
               type:PostalAddress
            type:Organization
      name:J. Nerup
      affiliation:
            name:Steno Diabetes Center
            address:
               name:Steno Diabetes Center, Gentofte, Denmark
               type:PostalAddress
            type:Organization
            name:University of Lund
            address:
               name:Department of Clinical Science, University of Lund, Lund, Sweden
               type:PostalAddress
            type:Organization
      name:C. Remacle
      affiliation:
            name:Université catholique de Louvain
            address:
               name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
      name:Steno Diabetes Center, Gentofte, Denmark
      name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
      name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
      name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium
      name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
      name:Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital Skejby, Aarhus, Denmark
      name:Steno Diabetes Center, Gentofte, Denmark
      name:Department of Clinical Science, University of Lund, Lund, Sweden
      name:Laboratoire de Biologie Cellulaire, Université catholique de Louvain, Louvain-la-Neuve, Belgium

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