DOI . ORG {}

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We began analyzing https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3658, but it redirected us to https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3658. The analysis below is for the second page.

Title[redir]:
Breast cancer intra-tumor heterogeneity | Breast Cancer Research | Full Text
Description:
In recent years it has become clear that cancer cells within a single tumor can display striking morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic and phenomenological data support the existence of intra-tumor genetic heterogeneity in breast cancers; however, its basis is yet to be fully defined. Two of the most widely evoked concepts to explain the origin of heterogeneity within tumors are the cancer stem cell hypothesis and the clonal evolution model. Although the cancer stem cell model appeared to provide an explanation for the variability among the neoplastic cells within a given cancer, advances in massively parallel sequencing have provided several lines of evidence to suggest that intra-tumor genetic heterogeneity likely plays a fundamental role in the phenotypic heterogeneity observed in cancers. Many challenges remain, however, in the interpretation of the next generation sequencing results obtained so far. Here we review the models that explain tumor heterogeneity, the causes of intra-tumor genetic diversity and their impact on our understanding and management of breast cancer, methods to study intra-tumor heterogeneity and the assessment of intra-tumor genetic heterogeneity in the clinic.

Matching Content Categories {📚}

Science
Education
Health & Fitness

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Custom-built

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🏙️ Massive Traffic: 50M - 100M visitors per month

Based on our best estimate, this website will receive around 91,115,781 visitors per month in the current month.

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Keywords {🔍}

cancer, heterogeneity, tumor, pubmed, cells, genetic, sequencing, breast, article, google, scholar, mutations, cas, clonal, cell, intratumor, cancers, tumors, nature, aberrations, central, dna, single, primary, evolution, situ, detection, analysis, genomic, stem, progression, number, model, csc, mps, selective, genome, singlecell, reisfilho, phenotypic, methods, ctcs, invasive, amplification, temporal, alterations, somatic, copy, bulk, circulating,

Topics {✒️}

routinely formalin-fixed paraffin-embedded triple-negative breast cancer full size image early-stage breast cancer metaplastic breast carcinomas metaplastic breast cancers intra-tumor heterogeneity poses single-molecule sequencing eliminates massively parallel sequencing intra-tumor genetic heterogeneity intra-tumor genetic diversity translating single-cell methods bmc genomics single-molecule sequencing platform single-molecule sequencing technologies single-cell sequencing genomics cancer stem cell detecting ultra-rare aberrations assessing intra-tumor heterogeneity profiling intra-tumor heterogeneity cell stem cell single-cell genetic analysis study intra-tumor heterogeneity authors scientific editing privacy choices/manage cookies allele-specific expression directly molecular analysis reveals cancer stem cells polygenomic breast cancers advanced breast cancer high-fidelity sequencing invasive breast cancer intra-tumour heterogeneity human breast cancer cell-surface markers cell population size breast cancer patients cancer cell plasticity intra-tumor heterogeneity sequencing depth employed intra-genic deletions open reading frame 1465-542x contact csc hypothesis states authors’ original file genetic heterogeneity observed somatic genetic aberrations driver aberration human breast tumours normal stem cells

Questions {❓}

Campbell LL, Polyak K: Breast tumor heterogeneity: cancer stem cells or clonal evolution?
Marusyk A, Almendro V, Polyak K: Intra-tumour heterogeneity: a looking glass for cancer?

Schema {🗺️}

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