
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Single-cell paired-end genome sequencing reveals structural variation per cell cycle - PMC
Description:
The nature and pace of genome mutation is largely unknown. Because standard methods sequence DNA from populations of cells, the genetic composition of individual cells is lost, de novo mutations in cells are concealed within the bulk signal and per ...
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Keywords {🔍}
singlecell, dna, number, read, cell, copy, doi, cells, pairedend, sequencing, figure, wga, mda, single, genome, pairs, mdasc, mapping, pair, pubmed, google, scholar, rearrangement, supplementary, analysis, reference, rearrangements, pmc, methods, human, chromosome, article, break, free, sequences, maps, logr, structural, count, sequence, signatures, bffc, map, nonwga, data, picoplex, deletion, amplification, artefacts, tandem,
Topics {✒️}
single-cell–refined paired-end map single-cell–refined paired-end maps single-cell paired-end map single-cell paired-end maps b8ff4c-refined paired-end map breakage-fusion-bridge cycles leading single-cell paired-end mapping single-cell paired-end sequencing low-coverage single-end sequencing picoplex-based single-cell sequencing single-cell read-depth profiles single-cell picoplex logr-segments single-cell snp call-rate single-cell ‘picoplex-sc2’ sample genome-wide single-cell analysis refined paired-end maps paired-end map cured sister tumour-cell ‘picoplex-sc10 single-cell ‘mda-sc82’ sample single-bacterium mda-amplified cells single-cell wga results european genome-phenome archive paired-end mapping increases b8f single-cell–derived subclones single-cell–derived hcc38 subclones reference paired-end map paired-end mapping analysis a6g single-cell–derived subclones paired-end sequence analysis g1-phase daughter cells single-cell sample γ-values paired-end sequence data fce adv_040-uz-kul fce adv_042-uz-kul jak2-negative myeloproliferative neoplasm focal read-depth counting single-cell exome sequencing single-cell sequencing enables single-cell picoplex-sequencing single-cell picoplex sequencing paired-end artefacts present sequence alignment/map format single-neuron sequencing analysis low-coverage sequence confirmed focal read-depth information focal read-depth anomalies single-cell sequences leading paired-end sequencing libraries single-cell read-depth digital b-allele frequencies
Questions {❓}
- Replication licensing and cancer—a fatal entanglement?
- What next for preimplantation genetic screening?
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