We are analyzing https://link.springer.com/article/10.1007/s10549-009-0461-7.

Title:
Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients | Breast Cancer Research and Treatment
Description:
Biocharacterization of circulating tumor cells (CTCs) in the peripheral blood of advanced breast cancer (ABC) patients may represent a real-time tumor biopsy. We assessed HER2 status on CTCs from blood samples of ABC patients. CTCs were separated and stained using the CellSearch System®. HER2 status was assessed by immunofluorescence and, when technically feasible, by fluorescence in situ hybridization. Blood samples were obtained from 66 ABC patients. Forty patients had a positive CTC sample (61%) and of these, 15 (37%) had HER2 + CTCs. We found non-concordant results in 32% of cases: 29% (8/28) of HER2-negative primary tumors had HER2-positive CTCs and 42% (5/12) of HER2-positive primary tumors had HER2-negative CTCs (k = 0.278). Our study suggests that a subset of patients with HER2-negative primary tumors develops HER2-positive CTCs during disease progression.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Health & Fitness
Science
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

While many websites aim to make money, others are created to share knowledge or showcase creativity. People build websites for various reasons. This could be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

cancer, breast, article, google, scholar, pubmed, tumor, cells, cas, circulating, patients, status, primary, clin, res, research, blood, metastatic, clinical, ctcs, access, oncol, tumors, herpositive, detection, privacy, cookies, content, silvia, leo, peripheral, disease, prognostic, italy, information, publish, search, correlation, pestrin, bessi, angelo, open, therapy, comparison, treat, unit, prato, data, log, journal,

Topics {✒️}

her2/neu-positive breast cancer month download article/chapter real-time tumor biopsy anti-her2 therapy her2-positive primary tumors her2-negative primary tumors angelo di leo positive ctc sample related subjects advanced breast cancer her2-positive ctcs metastatic breast cancer human breast cancer unknown her2 status full article pdf early breast cancer primary breast cancer breast cancer progresses breast cancer metastases recurrent breast cancer operable breast cancer her2-negative ctcs privacy choices/manage cookies circulating tumor cells breast cancer patients clinical oncology/college biological targeting therapy assessed her2 status epithelial tumor cells circulating tumour cells institutional research program breast cancer progression serum her2 levels cancer markers biostatistics unit ispo check access instant access tumor cells circulate disseminated tumor cells disseminating tumour cells annibale biggeri distant metastatic sites financial support provided tumor markers her2/neu oncogene article pestrin di leo european economic area hayes df specific biological properties

Questions {❓}

Hayes DF, Smerage J (2008) Is there a role for circulating tumor cells in the management of breast cancer?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients
         description:Biocharacterization of circulating tumor cells (CTCs) in the peripheral blood of advanced breast cancer (ABC) patients may represent a real-time tumor biopsy. We assessed HER2 status on CTCs from blood samples of ABC patients. CTCs were separated and stained using the CellSearch System®. HER2 status was assessed by immunofluorescence and, when technically feasible, by fluorescence in situ hybridization. Blood samples were obtained from 66 ABC patients. Forty patients had a positive CTC sample (61%) and of these, 15 (37%) had HER2 + CTCs. We found non-concordant results in 32% of cases: 29% (8/28) of HER2-negative primary tumors had HER2-positive CTCs and 42% (5/12) of HER2-positive primary tumors had HER2-negative CTCs (k = 0.278). Our study suggests that a subset of patients with HER2-negative primary tumors develops HER2-positive CTCs during disease progression.
         datePublished:2009-07-12T00:00:00Z
         dateModified:2009-07-12T00:00:00Z
         pageStart:523
         pageEnd:530
         sameAs:https://doi.org/10.1007/s10549-009-0461-7
         keywords:
            Breast cancer
            HER2 status
            Circulating tumor cells
            Predictive markers
            Anti-HER2 therapies
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10549-009-0461-7/MediaObjects/10549_2009_461_Fig1_HTML.jpg
         isPartOf:
            name:Breast Cancer Research and Treatment
            issn:
               1573-7217
               0167-6806
            volumeNumber:118
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Marta Pestrin
               affiliation:
                     name:Istituto Toscano Tumori
                     address:
                        name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Silvia Bessi
               affiliation:
                     name:Istituto Toscano Tumori
                     address:
                        name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Francesca Galardi
               affiliation:
                     name:Istituto Toscano Tumori
                     address:
                        name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mara Truglia
               affiliation:
                     name:Istituto Toscano Tumori
                     address:
                        name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Annibale Biggeri
               affiliation:
                     name:University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research)
                     address:
                        name:Department of Statistics “G. Parenti”, University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research), Florence, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chiara Biagioni
               affiliation:
                     name:Istituto Toscano Tumori
                     address:
                        name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Silvia Cappadona
               affiliation:
                     name:Istituto Toscano Tumori
                     address:
                        name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Laura Biganzoli
               affiliation:
                     name:Istituto Toscano Tumori
                     address:
                        name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Augusto Giannini
               affiliation:
                     name:Istituto Toscano Tumori
                     address:
                        name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Angelo Di Leo
               affiliation:
                     name:Istituto Toscano Tumori
                     address:
                        name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
                     name:Istituto Toscano Tumori
                     address:
                        name:“Sandro Pitigliani” Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Correlation of HER2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients
      description:Biocharacterization of circulating tumor cells (CTCs) in the peripheral blood of advanced breast cancer (ABC) patients may represent a real-time tumor biopsy. We assessed HER2 status on CTCs from blood samples of ABC patients. CTCs were separated and stained using the CellSearch System®. HER2 status was assessed by immunofluorescence and, when technically feasible, by fluorescence in situ hybridization. Blood samples were obtained from 66 ABC patients. Forty patients had a positive CTC sample (61%) and of these, 15 (37%) had HER2 + CTCs. We found non-concordant results in 32% of cases: 29% (8/28) of HER2-negative primary tumors had HER2-positive CTCs and 42% (5/12) of HER2-positive primary tumors had HER2-negative CTCs (k = 0.278). Our study suggests that a subset of patients with HER2-negative primary tumors develops HER2-positive CTCs during disease progression.
      datePublished:2009-07-12T00:00:00Z
      dateModified:2009-07-12T00:00:00Z
      pageStart:523
      pageEnd:530
      sameAs:https://doi.org/10.1007/s10549-009-0461-7
      keywords:
         Breast cancer
         HER2 status
         Circulating tumor cells
         Predictive markers
         Anti-HER2 therapies
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10549-009-0461-7/MediaObjects/10549_2009_461_Fig1_HTML.jpg
      isPartOf:
         name:Breast Cancer Research and Treatment
         issn:
            1573-7217
            0167-6806
         volumeNumber:118
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Marta Pestrin
            affiliation:
                  name:Istituto Toscano Tumori
                  address:
                     name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Silvia Bessi
            affiliation:
                  name:Istituto Toscano Tumori
                  address:
                     name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Francesca Galardi
            affiliation:
                  name:Istituto Toscano Tumori
                  address:
                     name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mara Truglia
            affiliation:
                  name:Istituto Toscano Tumori
                  address:
                     name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Annibale Biggeri
            affiliation:
                  name:University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research)
                  address:
                     name:Department of Statistics “G. Parenti”, University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research), Florence, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chiara Biagioni
            affiliation:
                  name:Istituto Toscano Tumori
                  address:
                     name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Silvia Cappadona
            affiliation:
                  name:Istituto Toscano Tumori
                  address:
                     name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Laura Biganzoli
            affiliation:
                  name:Istituto Toscano Tumori
                  address:
                     name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Augusto Giannini
            affiliation:
                  name:Istituto Toscano Tumori
                  address:
                     name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Angelo Di Leo
            affiliation:
                  name:Istituto Toscano Tumori
                  address:
                     name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
                  name:Istituto Toscano Tumori
                  address:
                     name:“Sandro Pitigliani” Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Breast Cancer Research and Treatment
      issn:
         1573-7217
         0167-6806
      volumeNumber:118
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Istituto Toscano Tumori
      address:
         name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
      name:Istituto Toscano Tumori
      address:
         name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
      name:Istituto Toscano Tumori
      address:
         name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
      name:Istituto Toscano Tumori
      address:
         name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
      name:University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research)
      address:
         name:Department of Statistics “G. Parenti”, University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research), Florence, Italy
         type:PostalAddress
      name:Istituto Toscano Tumori
      address:
         name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
      name:Istituto Toscano Tumori
      address:
         name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
      name:Istituto Toscano Tumori
      address:
         name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
      name:Istituto Toscano Tumori
      address:
         name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
      name:Istituto Toscano Tumori
      address:
         name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
      name:Istituto Toscano Tumori
      address:
         name:“Sandro Pitigliani” Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Marta Pestrin
      affiliation:
            name:Istituto Toscano Tumori
            address:
               name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
      name:Silvia Bessi
      affiliation:
            name:Istituto Toscano Tumori
            address:
               name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
      name:Francesca Galardi
      affiliation:
            name:Istituto Toscano Tumori
            address:
               name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
      name:Mara Truglia
      affiliation:
            name:Istituto Toscano Tumori
            address:
               name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
      name:Annibale Biggeri
      affiliation:
            name:University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research)
            address:
               name:Department of Statistics “G. Parenti”, University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research), Florence, Italy
               type:PostalAddress
            type:Organization
      name:Chiara Biagioni
      affiliation:
            name:Istituto Toscano Tumori
            address:
               name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
      name:Silvia Cappadona
      affiliation:
            name:Istituto Toscano Tumori
            address:
               name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
      name:Laura Biganzoli
      affiliation:
            name:Istituto Toscano Tumori
            address:
               name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
      name:Augusto Giannini
      affiliation:
            name:Istituto Toscano Tumori
            address:
               name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
      name:Angelo Di Leo
      affiliation:
            name:Istituto Toscano Tumori
            address:
               name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
            name:Istituto Toscano Tumori
            address:
               name:“Sandro Pitigliani” Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
      name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
      name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
      name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
      name:Department of Statistics “G. Parenti”, University of Florence and Biostatistics Unit ISPO (Institute for Cancer Prevention and Research), Florence, Italy
      name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
      name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
      name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
      name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
      name:Translational Research Unit c/o Department of Oncology, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
      name:“Sandro Pitigliani” Medical Oncology Unit, Hospital of Prato, Istituto Toscano Tumori, Prato, Italy
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(143)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.99s.

LINK . SPRINGER . COM {}