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cancer, breast, pubmed, expression, google, scholar, article, cas, tumors, androgen, tumor, patients, mmp, score, tissue, analysis, receptor, mmps, cells, study, carcinomas, data, receptors, significant, survival, carcinoma, arpositive, immunostaining, found, relationship, matrix, metastases, authors, status, timps, immunohistochemical, results, positive, prognostic, cell, invasive, cases, distant, table, bmc, higher, expressed, sections, clinicopathological, gonzalez,

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springer nature author information authors tissue array block references kuenen-boumeester invasive ductal carcinoma pathology laboratory files tissue array blocks 'donor' tumor block author correspondence authors’ original file methods patient characteristics total immunostaining scores apocrine carcinoma invasive ductal carcinomas long-term tissue culture 1309/42f0-0d0d-jd0j-5edt 1309/pef8-gl6f-ywmc-ag56 information important intellectual content blue background open access article immunostaining score values conclusion real-time rt-pcr authors scientific editing apocrine breast lesions ductal carcinoma ar-positive ductal carcinomas cleaving pro-apoptotic factors unknown primary site pre-publication history invasive breast cancers diaz-chico jc du-145 carcinoma cells immunostaining score methods invasive breast carcinomas privacy choices/manage cookies total score evaluate immunostaining intensity serial 5-μm sections apocrine carcinomas ar-negative tumors show primary cancer lymph node involvement full size image eosin-stained sections numeric score ranging ar-positive tumors' capability apocrine metaplasia

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         headline:Androgen receptor expresion in breast cancer: Relationship with clinicopathological characteristics of the tumors, prognosis, and expression of metalloproteases and their inhibitors
         description:In the present study we analyze, in patients with breast cancer, the tumor expression of androgen receptors (AR), its relationship with clinicopathological characteristics and with the expression of several matrix metalloproteases (MMPs) and their inhibitors (TIMPs), as well as with prognosis. An immunohistochemical study was performed using tissue microarrays and specific antibodies against AR, MMPs -1, -2, -7, -9, -11, -13, -14, and TIMPs -1, -2 and -3. More than 2,800 determinations on tumor specimens from 111 patients with primary invasive ductal carcinoma of the breast (52 with axillary lymph node metastases and 59 without them) and controls were performed. Staining results were categorized using a score based on the intensity of the staining and a specific software program calculated the percentage of immunostained cells automatically. A total of 83 cases (74.8%) showed a positive immunostaining for AR, but with a wide variation in the staining score values. There were no significant associations between the total immunostaining scores for AR and any clinicopathological parameters. However, score values for MMP-1, -7 and -13, were significantly higher in AR-positive tumors than in AR-negative tumors. Likewise, when we considered the cellular type expressing each factor, we found that AR-positive tumors had a higher percentage of cases positive for MMP-1, -7, -11, and TIMP-2 in their malignant cells, as well as for MMP-1 in intratumoral fibroblasts. On the other hand, multivariate analysis demonstrated that patients with AR-positive tumors have a significant longer overall survival than those with AR-negative breast carcinomas (p = 0.03). Our results confirm that AR are commonly expressed in breast cancer, and are correlated with the expression of some MMPs and TIMP-2. Although we found a specific value of AR expression to be a prognostic indicator in breast cancer, the functional role of AR in these neoplasms is still unclear and further data are needed in order to clarify their biological signification in breast cancer.
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      headline:Androgen receptor expresion in breast cancer: Relationship with clinicopathological characteristics of the tumors, prognosis, and expression of metalloproteases and their inhibitors
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         Apocrine Breast Carcinoma
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               name:Unidad de Investigación, Hospital de Jove, Gijón, Spain
               type:PostalAddress
            type:Organization
            name:Instituto Universitario de Oncología del Principado de Asturias
            address:
               name:Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
               type:PostalAddress
            type:Organization
            name:Hospital de Jove
            address:
               name:Servicio de Cirugía General, Hospital de Jove, Gijón, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Unidad de Investigación, Hospital de Jove, Gijón, Spain
      name:Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
      name:Servicio de Anatomía Patológica, Hospital de Jove, Gijón, Spain
      name:Unidad de Investigación, Hospital de Jove, Gijón, Spain
      name:Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
      name:Servicio de Ginecología, Hospital Álvarez Buylla, Mieres, Spain
      name:Unidad de Investigación, Hospital de Jove, Gijón, Spain
      name:Unidad de Investigación, Hospital de Jove, Gijón, Spain
      name:Unidad de Investigación, Hospital de Jove, Gijón, Spain
      name:Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
      name:Servicio de Cirugía General, Hospital de Jove, Gijón, Spain
      name:Unidad de Investigación, Hospital de Jove, Gijón, Spain
      name:Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
      name:Servicio de Ginecología, Hospital de Jove, Gijón, Spain
      name:Unidad de Investigación, Hospital de Jove, Gijón, Spain
      name:Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Spain
      name:Servicio de Cirugía General, Hospital de Jove, Gijón, Spain

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