We are analyzing https://link.springer.com/article/10.1007/s00428-006-0213-6.

Title:
Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer | Virchows Archiv
Description:
The purpose of this study was to investigate the influence of androgen receptor (AR) expression in tumour tissue on survival of patients with metastatic breast cancer. Tumour specimens from 232 patients with metastatic breast cancer were examined for presence of AR by immunohistochemistry. According to the extent of immunostaining, AR expression was classified as score 0, 1+, 2+, or 3+. AR positivity was observed in 164 (70.7%) tumours. The median survival after disease recurrence (SAR) of patients with AR-expressing tumours was significantly longer compared to that of patients with AR-negative tumours (21.89 months, 95% CI 17.23–26.55 vs 11.99 months, 95% CI 9.36–14.62; log-rank test 0.0282). In addition, patients with AR score 3+ had a significantly longer disease-free survival (DFS) compared to patients with AR score 0, 1+, and 2+, (24.67 months, 95% CI 13.72–35.62 vs 16.36 months, 95% CI 13.18–19.54, log-rank test 0.0043). Multivariate Cox analyses showed no statistically significant influence of AR expression on DFS or SAR. In conclusion, SAR is significantly longer in patients with AR-expressing breast carcinoma. However, AR expression is not an independent prognostic factor for SAR in metastatic breast cancer.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Games

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,603,724 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

cancer, breast, article, pubmed, google, scholar, cas, prognostic, androgen, receptor, expression, receptors, patients, metastatic, estrogen, survival, access, study, privacy, cookies, content, carcinoma, factors, publish, search, virchows, significance, schippinger, regitnig, sar, months, open, immunohistochemical, oncol, graz, data, information, log, journal, research, april, walter, dandachi, moinfar, score, tumours, recurrence, significantly, longer, discover,

Topics {✒️}

month download article/chapter population-based study ar-expressing breast carcinoma related subjects metastatic breast carcinoma full article pdf prognostic markers metastatic breast cancer privacy choices/manage cookies national cancer institute pathological prognostic factors androgen receptor expression klaus-dieter wernecke androgen receptor activity breast cancer mortality human breast cancer operable breast cancer primary breast cancer hormone receptor status progesterone receptor levels progesterone receptor status progestogen receptor activity benign breast tumors independent prognostic factor joint estrogen receptor check access instant access breast cancer classified european economic area multivariate analysis approach long-term follow van der kwast henzen-logmans sc cell biological parameters adjuvant tamoxifen treatment article schippinger androgen receptors frequently conditions privacy policy significantly longer compared stanford jl disease recurrence phase ii study log-rank test 0 article log ar-negative tumours sledge gw jr breast carcinoma early recurrence accepting optional cookies ar-expressing tumours

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer
         description:The purpose of this study was to investigate the influence of androgen receptor (AR) expression in tumour tissue on survival of patients with metastatic breast cancer. Tumour specimens from 232 patients with metastatic breast cancer were examined for presence of AR by immunohistochemistry. According to the extent of immunostaining, AR expression was classified as score 0, 1+, 2+, or 3+. AR positivity was observed in 164 (70.7%) tumours. The median survival after disease recurrence (SAR) of patients with AR-expressing tumours was significantly longer compared to that of patients with AR-negative tumours (21.89 months, 95% CI 17.23–26.55 vs 11.99 months, 95% CI 9.36–14.62; log-rank test 0.0282). In addition, patients with AR score 3+ had a significantly longer disease-free survival (DFS) compared to patients with AR score 0, 1+, and 2+, (24.67 months, 95% CI 13.72–35.62 vs 16.36 months, 95% CI 13.18–19.54, log-rank test 0.0043). Multivariate Cox analyses showed no statistically significant influence of AR expression on DFS or SAR. In conclusion, SAR is significantly longer in patients with AR-expressing breast carcinoma. However, AR expression is not an independent prognostic factor for SAR in metastatic breast cancer.
         datePublished:2006-04-21T00:00:00Z
         dateModified:2006-04-21T00:00:00Z
         pageStart:24
         pageEnd:30
         sameAs:https://doi.org/10.1007/s00428-006-0213-6
         keywords:
            Metastatic breast cancer
            Androgen receptor
            Prognostic factors
            Pathology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-006-0213-6/MediaObjects/428_2006_213_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-006-0213-6/MediaObjects/428_2006_213_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-006-0213-6/MediaObjects/428_2006_213_Fig3_HTML.gif
         isPartOf:
            name:Virchows Archiv
            issn:
               1432-2307
               0945-6317
            volumeNumber:449
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Walter Schippinger
               affiliation:
                     name:Medical University of Graz
                     address:
                        name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Peter Regitnig
               affiliation:
                     name:Medical University Graz
                     address:
                        name:Institute of Pathology, Medical University Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nadia Dandachi
               affiliation:
                     name:Medical University of Graz
                     address:
                        name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Klaus-Dieter Wernecke
               affiliation:
                     name:Humboldt University of Berlin
                     address:
                        name:Institute of Medical Biometry, Humboldt University of Berlin, Berlin, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thomas Bauernhofer
               affiliation:
                     name:Medical University of Graz
                     address:
                        name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hellmut Samonigg
               affiliation:
                     name:Medical University of Graz
                     address:
                        name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Farid Moinfar
               affiliation:
                     name:Medical University Graz
                     address:
                        name:Institute of Pathology, Medical University Graz, Graz, Austria
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Evaluation of the prognostic significance of androgen receptor expression in metastatic breast cancer
      description:The purpose of this study was to investigate the influence of androgen receptor (AR) expression in tumour tissue on survival of patients with metastatic breast cancer. Tumour specimens from 232 patients with metastatic breast cancer were examined for presence of AR by immunohistochemistry. According to the extent of immunostaining, AR expression was classified as score 0, 1+, 2+, or 3+. AR positivity was observed in 164 (70.7%) tumours. The median survival after disease recurrence (SAR) of patients with AR-expressing tumours was significantly longer compared to that of patients with AR-negative tumours (21.89 months, 95% CI 17.23–26.55 vs 11.99 months, 95% CI 9.36–14.62; log-rank test 0.0282). In addition, patients with AR score 3+ had a significantly longer disease-free survival (DFS) compared to patients with AR score 0, 1+, and 2+, (24.67 months, 95% CI 13.72–35.62 vs 16.36 months, 95% CI 13.18–19.54, log-rank test 0.0043). Multivariate Cox analyses showed no statistically significant influence of AR expression on DFS or SAR. In conclusion, SAR is significantly longer in patients with AR-expressing breast carcinoma. However, AR expression is not an independent prognostic factor for SAR in metastatic breast cancer.
      datePublished:2006-04-21T00:00:00Z
      dateModified:2006-04-21T00:00:00Z
      pageStart:24
      pageEnd:30
      sameAs:https://doi.org/10.1007/s00428-006-0213-6
      keywords:
         Metastatic breast cancer
         Androgen receptor
         Prognostic factors
         Pathology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-006-0213-6/MediaObjects/428_2006_213_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-006-0213-6/MediaObjects/428_2006_213_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00428-006-0213-6/MediaObjects/428_2006_213_Fig3_HTML.gif
      isPartOf:
         name:Virchows Archiv
         issn:
            1432-2307
            0945-6317
         volumeNumber:449
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Walter Schippinger
            affiliation:
                  name:Medical University of Graz
                  address:
                     name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Peter Regitnig
            affiliation:
                  name:Medical University Graz
                  address:
                     name:Institute of Pathology, Medical University Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nadia Dandachi
            affiliation:
                  name:Medical University of Graz
                  address:
                     name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Klaus-Dieter Wernecke
            affiliation:
                  name:Humboldt University of Berlin
                  address:
                     name:Institute of Medical Biometry, Humboldt University of Berlin, Berlin, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas Bauernhofer
            affiliation:
                  name:Medical University of Graz
                  address:
                     name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hellmut Samonigg
            affiliation:
                  name:Medical University of Graz
                  address:
                     name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Farid Moinfar
            affiliation:
                  name:Medical University Graz
                  address:
                     name:Institute of Pathology, Medical University Graz, Graz, Austria
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Virchows Archiv
      issn:
         1432-2307
         0945-6317
      volumeNumber:449
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Medical University of Graz
      address:
         name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
         type:PostalAddress
      name:Medical University Graz
      address:
         name:Institute of Pathology, Medical University Graz, Graz, Austria
         type:PostalAddress
      name:Medical University of Graz
      address:
         name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
         type:PostalAddress
      name:Humboldt University of Berlin
      address:
         name:Institute of Medical Biometry, Humboldt University of Berlin, Berlin, Germany
         type:PostalAddress
      name:Medical University of Graz
      address:
         name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
         type:PostalAddress
      name:Medical University of Graz
      address:
         name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
         type:PostalAddress
      name:Medical University Graz
      address:
         name:Institute of Pathology, Medical University Graz, Graz, Austria
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Walter Schippinger
      affiliation:
            name:Medical University of Graz
            address:
               name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Peter Regitnig
      affiliation:
            name:Medical University Graz
            address:
               name:Institute of Pathology, Medical University Graz, Graz, Austria
               type:PostalAddress
            type:Organization
      name:Nadia Dandachi
      affiliation:
            name:Medical University of Graz
            address:
               name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
               type:PostalAddress
            type:Organization
      name:Klaus-Dieter Wernecke
      affiliation:
            name:Humboldt University of Berlin
            address:
               name:Institute of Medical Biometry, Humboldt University of Berlin, Berlin, Germany
               type:PostalAddress
            type:Organization
      name:Thomas Bauernhofer
      affiliation:
            name:Medical University of Graz
            address:
               name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
               type:PostalAddress
            type:Organization
      name:Hellmut Samonigg
      affiliation:
            name:Medical University of Graz
            address:
               name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
               type:PostalAddress
            type:Organization
      name:Farid Moinfar
      affiliation:
            name:Medical University Graz
            address:
               name:Institute of Pathology, Medical University Graz, Graz, Austria
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
      name:Institute of Pathology, Medical University Graz, Graz, Austria
      name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
      name:Institute of Medical Biometry, Humboldt University of Berlin, Berlin, Germany
      name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
      name:Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
      name:Institute of Pathology, Medical University Graz, Graz, Austria
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(94)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.82s.

LINK . SPRINGER . COM {}