We are analyzing https://link.springer.com/article/10.1186/bcr593.

Title:
The role of androgens and polymorphisms in the androgen receptor in the epidemiology of breast cancer | Breast Cancer Research
Description:
Testosterone binds to the androgen receptor in target tissue to mediate its effects. Variations in testosterone levels and androgen receptor activity may play a role in the etiology of breast cancer. Here, we review the epidemiologic evidence linking endogenous testosterone to breast cancer risk. Paradoxically, results from observational studies that have examined polymorphisms in the androgen receptor suggest that the low-activity androgen receptor increases breast cancer risk. We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide.
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Keywords {🔍}

cancer, breast, testosterone, pubmed, google, scholar, cas, risk, studies, androgen, levels, article, women, receptor, repeat, study, postmenopausal, association, results, gene, arcag, serum, increased, length, androgens, premenopausal, observed, reported, cag, clin, effects, hormone, prospective, res, human, significant, table, cell, prostate, allele, central, role, receptors, menopause, bias, measurement, effect, null, long, sex,

Topics {✒️}

population-based case–control study leslie bernstein & giske ursin sex hormone-binding globulin dna-binding domain resulting estrogen-induced cell proliferation ar-cag repeat polymorphism smaller cross-sectional studies case–control studies published ar-cag repeat length long ar-cag repeat peak levels mid-cycle sex hormone levels n-expanded neuronopathies privacy choices/manage cookies steroid hormone receptors ggn repeat lengths reduced trans-activation ar-cag repeat androgen receptor activity polymorphic cag repeat shorter cag repeat cag repeat lengths testosterone–breast cancer association breast cell proliferation human androgen receptor corticosteroid-binding globulin nurses' health study normal size range case–cohort study [19] case–control studies human breast cancer single hormone measurement body mass index lubahn db impaired sperm production male breast carcinoma androgen receptor gene androgen receptor protein androgen receptor locus androgen receptor variants ggc repeat length breast cancer risk breast cancer proliferation male breast cancer natl cancer inst statistically significant increase breast cancer prevention breast cancer patients subsequent breast cancer operable breast cancer

Questions {❓}

Can the observed association between testosterone levels and breast cancer risk be due to bias?
If the long AR-CAG repeat (less active AR) is associated with increased breast cancer risk in postmenopausal women, then how do these results coincide with results showing that increased testosterone levels increase postmenopausal breast cancer risk?
The Androgen Receptor: Is It a Promising Target?

Schema {🗺️}

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         description:Testosterone binds to the androgen receptor in target tissue to mediate its effects. Variations in testosterone levels and androgen receptor activity may play a role in the etiology of breast cancer. Here, we review the epidemiologic evidence linking endogenous testosterone to breast cancer risk. Paradoxically, results from observational studies that have examined polymorphisms in the androgen receptor suggest that the low-activity androgen receptor increases breast cancer risk. We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide.
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      description:Testosterone binds to the androgen receptor in target tissue to mediate its effects. Variations in testosterone levels and androgen receptor activity may play a role in the etiology of breast cancer. Here, we review the epidemiologic evidence linking endogenous testosterone to breast cancer risk. Paradoxically, results from observational studies that have examined polymorphisms in the androgen receptor suggest that the low-activity androgen receptor increases breast cancer risk. We review the quality of this evidence and conclude with a discussion of how the androgen receptor and testosterone results coincide.
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         breast cancer
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         Oncology
         Surgical Oncology
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