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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. Social Networks
  11. External Links
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  13. Libraries
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  15. CDN Services

We began analyzing https://www.nature.com/articles/6691522, but it redirected us to https://www.nature.com/articles/6691522. The analysis below is for the second page.

Title[redir]:
C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance | British Journal of Cancer
Description:
Data from basic research suggests that amplification of the proto-oncogene c-myc is important in breast cancer pathogenesis, but its frequency of amplification and prognostic relevance in human studies have been inconsistent. In an effort to clarify the clinical significance of c-myc amplification in breast cancer, we conducted a comprehensive literature search and a meta-analysis in which 29 studies were evaluated. The weighted average frequency of c-myc amplification in breast tumours was 15.7% (95% CI = 12.5–18.8%), although estimates in individual studies exhibited significant heterogeneity, P<0.0001. C-myc amplification exhibited significant but weak associations with tumour grade (RR = 1.61), lymph-node metastasis (RR = 1.24), negative progesterone receptor status (RR = 1.27), and postmenopausal status (RR = 0.82). Amplification was significantly associated with risk of relapse and death, with pooled estimates RR = 2.05 (95% CI = 1.51–2.78) and RR = 1.74 (95% CI = 1.27–2.39), respectively. This effect did not appear to be merely a surrogate for other prognostic factors. These results suggest that c-myc amplification is relatively common in breast cancer and may provide independent prognostic information. More rigorous studies with consistent methodology are required to validate this association, and to investigate its potential as a molecular predictor of specific therapy response. © 2000 Cancer Research Campaign http://www.bjcancer.com

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Non-Profit & Charity

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We can't see how the site brings in money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Doi.org could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

cancer, google, scholar, breast, pubmed, article, cas, cmyc, amplification, human, res, nature, prognostic, oncogene, cerbb, cell, research, int, carcinomas, content, tumor, central, cookies, open, metaanalysis, protooncogene, clinical, primary, privacy, analysis, data, access, studies, patients, gene, oncogenes, genes, genetic, expression, information, journal, nass, dickson, trock, tumour, independent, publication, chromosomal, carcinoma, van,

Topics {✒️}

nature portfolio privacy policy c-erbb-2/cerba coamplification indicative advertising nature 299 nature 306 nature basic research suggests social media cancer research 0/ reprints epidemiologic research chromosome 1p32-pter controls c-erbb-2/neu proto-oncogenes node-negative breast carcinomas c-ha-ras protooncogenes normal development proto-oncogene c-myc c-myc proto-oncogene poor short-term prognosis c-myc proto-oncogenes c-myc oncogene amplification c-myc gene amplification permissions personal data development hormone receptor+ve data protection high cell kinetics lymph-node metastasis lymph node metastasis c-myc genes human breast cancer human breast carcinomas her2/neu amplification privacy �statistically significant’ clinically breast cancer patients c-myc oncogene c-myc protooncogene human breast tumors myc family genes primary breast cancer c-myc amplification c-myc gene breast cancer pathogenesis breast cancer imprints breast cancer depends explore content similar content

Questions {❓}

  • Hayes DF, Trock B and Harris AL (1998) Assessing the clinical impact of prognostic factors: when is ‘statistically significant’ clinically useful?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance
         description:Data from basic research suggests that amplification of the proto-oncogene c-myc is important in breast cancer pathogenesis, but its frequency of amplification and prognostic relevance in human studies have been inconsistent. In an effort to clarify the clinical significance of c-myc amplification in breast cancer, we conducted a comprehensive literature search and a meta-analysis in which 29 studies were evaluated. The weighted average frequency of c-myc amplification in breast tumours was 15.7% (95% CI = 12.5–18.8%), although estimates in individual studies exhibited significant heterogeneity, P<0.0001. C-myc amplification exhibited significant but weak associations with tumour grade (RR = 1.61), lymph-node metastasis (RR = 1.24), negative progesterone receptor status (RR = 1.27), and postmenopausal status (RR = 0.82). Amplification was significantly associated with risk of relapse and death, with pooled estimates RR = 2.05 (95% CI = 1.51–2.78) and RR = 1.74 (95% CI = 1.27–2.39), respectively. This effect did not appear to be merely a surrogate for other prognostic factors. These results suggest that c-myc amplification is relatively common in breast cancer and may provide independent prognostic information. More rigorous studies with consistent methodology are required to validate this association, and to investigate its potential as a molecular predictor of specific therapy response. © 2000 Cancer Research Campaign http://www.bjcancer.com
         datePublished:2000-12-05T00:00:00Z
         dateModified:2011-11-16T00:00:00Z
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      headline:C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance
      description:Data from basic research suggests that amplification of the proto-oncogene c-myc is important in breast cancer pathogenesis, but its frequency of amplification and prognostic relevance in human studies have been inconsistent. In an effort to clarify the clinical significance of c-myc amplification in breast cancer, we conducted a comprehensive literature search and a meta-analysis in which 29 studies were evaluated. The weighted average frequency of c-myc amplification in breast tumours was 15.7% (95% CI = 12.5–18.8%), although estimates in individual studies exhibited significant heterogeneity, P<0.0001. C-myc amplification exhibited significant but weak associations with tumour grade (RR = 1.61), lymph-node metastasis (RR = 1.24), negative progesterone receptor status (RR = 1.27), and postmenopausal status (RR = 0.82). Amplification was significantly associated with risk of relapse and death, with pooled estimates RR = 2.05 (95% CI = 1.51–2.78) and RR = 1.74 (95% CI = 1.27–2.39), respectively. This effect did not appear to be merely a surrogate for other prognostic factors. These results suggest that c-myc amplification is relatively common in breast cancer and may provide independent prognostic information. More rigorous studies with consistent methodology are required to validate this association, and to investigate its potential as a molecular predictor of specific therapy response. © 2000 Cancer Research Campaign http://www.bjcancer.com
      datePublished:2000-12-05T00:00:00Z
      dateModified:2011-11-16T00:00:00Z
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         amplification
         breast cancer
         prognostic markers
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         Cancer Research
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         Molecular Medicine
         Oncology
         Drug Resistance
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Social Networks {👍}(1)

External Links {🔗}(250)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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