We are analyzing https://link.springer.com/article/10.1007/bf01613296.

Title:
Genomic alterations of the c-myc protooncogene in relation to the overexpression of c-erbB2 and Ki-67 in human breast and cervix carcinomas | Journal of Cancer Research and Clinical Oncology
Description:
Genomic alterations of c-myc (amplification, rearrangements and hypomethylation) were investigated in 30 breast carcinomas and 20 cervix carcinomas. In breast carcinomas c-myc alterations were compared with overexpression of the c-erbB2 protooncogene and the proliferation marker Ki-67. Alterations of c-myc were found in 50% of the breast carcinomas and in 25% of the cervix carcinomas. In 23% of the breast carcinomas c-erbB2 overexpression was associated with c-myc alterations. In 17% of the cases there was overexpression of c-erbB2 without detectable alterations of c-myc. Hence, in 67% of breast cancers alterations of c-myc and/or c-erbB2 have been found, while in 81% of the samples Ki-67 expression was increased. The results suggest that the study of c-myc alterations provides an important complement to that of other prognostic indicators of breast cancer such as c-erbB2 expression.
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Keywords {🔍}

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Topics {✒️}

c-erb-b2 gene amplification transformation-specific rna sequences month download article/chapter dna methylation byn-nitrosomorpholine human c-myc locus situ c-myc expression clinical oncology aims breast cancers alterations c-erbb-2 oncoprotein c-erbb2 protooncogene human breast cancer c-myc protooncogene related subjects twelve major cancers privacy choices/manage cookies c-myc genes c-myc locus c-myc protein liver nodules theneu oncogene encodes human breast carcinomas c-myc alterations receptor protein similar c-myc oncogene full article pdf c-erbb2 expression human cancer cells proliferation marker ki-67 monoclonal antibody ki-67 samples ki-67 expression infiltrating ductal carcinomas human breast carcinoma european economic area scope submit manuscript single-centre experience simple repetitive sequence robert-koch-straße 40 conditions privacy policy nucleotide sequence analysis cancer research breast cancer cellular signal transduction theher-2/neu oncogene cell cycle analysis accepting optional cookies 20 cervix carcinomas cervix carcinomas check access instant access cytoplasmic actin

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      description:Genomic alterations of c-myc (amplification, rearrangements and hypomethylation) were investigated in 30 breast carcinomas and 20 cervix carcinomas. In breast carcinomas c-myc alterations were compared with overexpression of the c-erbB2 protooncogene and the proliferation marker Ki-67. Alterations of c-myc were found in 50% of the breast carcinomas and in 25% of the cervix carcinomas. In 23% of the breast carcinomas c-erbB2 overexpression was associated with c-myc alterations. In 17% of the cases there was overexpression of c-erbB2 without detectable alterations of c-myc. Hence, in 67% of breast cancers alterations of c-myc and/or c-erbB2 have been found, while in 81% of the samples Ki-67 expression was increased. The results suggest that the study of c-myc alterations provides an important complement to that of other prognostic indicators of breast cancer such as c-erbB2 expression.
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