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We are analyzing https://www.nature.com/articles/6691522.

Title:
C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance | British Journal of Cancer
Description:
Data from basic research suggests that amplification of the proto-oncogene c-myc is important in breast cancer pathogenesis, but its frequency of amplification and prognostic relevance in human studies have been inconsistent. In an effort to clarify the clinical significance of c-myc amplification in breast cancer, we conducted a comprehensive literature search and a meta-analysis in which 29 studies were evaluated. The weighted average frequency of c-myc amplification in breast tumours was 15.7% (95% CI = 12.5–18.8%), although estimates in individual studies exhibited significant heterogeneity, P<0.0001. C-myc amplification exhibited significant but weak associations with tumour grade (RR = 1.61), lymph-node metastasis (RR = 1.24), negative progesterone receptor status (RR = 1.27), and postmenopausal status (RR = 0.82). Amplification was significantly associated with risk of relapse and death, with pooled estimates RR = 2.05 (95% CI = 1.51–2.78) and RR = 1.74 (95% CI = 1.27–2.39), respectively. This effect did not appear to be merely a surrogate for other prognostic factors. These results suggest that c-myc amplification is relatively common in breast cancer and may provide independent prognostic information. More rigorous studies with consistent methodology are required to validate this association, and to investigate its potential as a molecular predictor of specific therapy response. © 2000 Cancer Research Campaign http://www.bjcancer.com
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Non-Profit & Charity

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our estimates place Nature.com's monthly online earnings from display ads at $42,042 to $115,616.

Keywords {🔍}

cancer, google, scholar, breast, pubmed, article, cas, cmyc, amplification, human, res, nature, prognostic, oncogene, cerbb, cell, research, int, carcinomas, content, tumor, central, cookies, open, metaanalysis, protooncogene, clinical, primary, privacy, analysis, data, access, studies, patients, gene, oncogenes, genes, genetic, expression, information, journal, nass, dickson, trock, tumour, independent, publication, chromosomal, carcinoma, van,

Topics {✒️}

nature portfolio privacy policy c-erbb-2/cerba coamplification indicative advertising nature 299 nature 306 nature basic research suggests social media cancer research 0/ reprints epidemiologic research chromosome 1p32-pter controls c-erbb-2/neu proto-oncogenes node-negative breast carcinomas c-ha-ras protooncogenes normal development proto-oncogene c-myc c-myc proto-oncogene poor short-term prognosis c-myc proto-oncogenes c-myc oncogene amplification c-myc gene amplification permissions personal data development hormone receptor+ve data protection high cell kinetics lymph-node metastasis lymph node metastasis c-myc genes human breast cancer human breast carcinomas her2/neu amplification privacy �statistically significant’ clinically breast cancer patients c-myc oncogene c-myc protooncogene human breast tumors myc family genes primary breast cancer c-myc amplification c-myc gene breast cancer pathogenesis breast cancer imprints breast cancer depends explore content similar content

Questions {❓}

  • Hayes DF, Trock B and Harris AL (1998) Assessing the clinical impact of prognostic factors: when is ‘statistically significant’ clinically useful?

Schema {🗺️}

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      headline:C-myc amplification in breast cancer: a meta-analysis of its occurrence and prognostic relevance
      description:Data from basic research suggests that amplification of the proto-oncogene c-myc is important in breast cancer pathogenesis, but its frequency of amplification and prognostic relevance in human studies have been inconsistent. In an effort to clarify the clinical significance of c-myc amplification in breast cancer, we conducted a comprehensive literature search and a meta-analysis in which 29 studies were evaluated. The weighted average frequency of c-myc amplification in breast tumours was 15.7% (95% CI = 12.5–18.8%), although estimates in individual studies exhibited significant heterogeneity, P<0.0001. C-myc amplification exhibited significant but weak associations with tumour grade (RR = 1.61), lymph-node metastasis (RR = 1.24), negative progesterone receptor status (RR = 1.27), and postmenopausal status (RR = 0.82). Amplification was significantly associated with risk of relapse and death, with pooled estimates RR = 2.05 (95% CI = 1.51–2.78) and RR = 1.74 (95% CI = 1.27–2.39), respectively. This effect did not appear to be merely a surrogate for other prognostic factors. These results suggest that c-myc amplification is relatively common in breast cancer and may provide independent prognostic information. More rigorous studies with consistent methodology are required to validate this association, and to investigate its potential as a molecular predictor of specific therapy response. © 2000 Cancer Research Campaign http://www.bjcancer.com
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