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DOI . ORG {}

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We began analyzing https://www.nature.com/articles/nsmb.2230, but it redirected us to https://www.nature.com/articles/nsmb.2230. The analysis below is for the second page.

Title[redir]:
An alternative mode of microRNA target recognition | Nature Structural & Molecular Biology
Description:
MicroRNAs are thought to repress mRNA targets through perfect pairing with their seed region, but a sizeable number of miRNA interaction sites are orphans, without a perfect canonical miRNA partner. Now a large number of miRNAs are found to use an alternative binding mode that involves the bulging out of an unpaired mRNA nucleotide, leading to a functional mRNA-miRNA interaction. MicroRNAs (miRNAs) regulate mRNA targets through perfect pairing with their seed region (positions 2–7). Recently, a precise genome-wide map of miRNA interaction sites in mouse brain was generated by high-throughput sequencing and analysis of clusters of ~50-nucleotide mRNA tags cross-linked to Argonaute (Ago HITS-CLIP). By analyzing Ago HITS-CLIP

Matching Content Categories {📚}

  • Education
  • Science
  • Animals & Wildlife

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 80,479,999 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We're unsure if the website is profiting.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

article, cas, google, scholar, nature, cell, microrna, rna, mol, micrornas, access, chi, nat, target, sites, biol, content, wook, darnell, argonaute, cookies, molecular, recognition, sung, hannon, mirnas, brain, hitsclip, struct, silencing, privacy, data, structural, biology, targets, pairing, seed, ago, binding, open, regulation, genes, health, institute, research, supplementary, information, alternative, mouse, interactions,

Topics {✒️}

nature portfolio permissions reprints privacy policy inosine editing author information authors research advertising social media ago clip-based imputation sung wook chi development precise genome-wide map piwi/mid domain protein microrna targeting specificity ago hits-clip facilitate age-specific functions nature 431 nature 433 nature 455 nature 456 nature 460 nature 466 nature 461 nature ago-mirna interactions regulate mrna targets seed-target recognition step springerlink instant access mirna interaction sites permissions risc slicer activity cold spring harbor personal data samsung advanced institute mirna-target interactions mir-302/367 microrna cluster samsung medical center genome-wide identification article chi data protection ago silencing complexes microrna target recognition privacy mice lacking mirna-1–2 microrna targeting code g-bulge sites competing financial interests microrna target sites microrna/target duplexes ago2 binding sites

Schema {🗺️}

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         headline:An alternative mode of microRNA target recognition
         description:MicroRNAs are thought to repress mRNA targets through perfect pairing with their seed region, but a sizeable number of miRNA interaction sites are orphans, without a perfect canonical miRNA partner. Now a large number of miRNAs are found to use an alternative binding mode that involves the bulging out of an unpaired mRNA nucleotide, leading to a functional mRNA-miRNA interaction. MicroRNAs (miRNAs) regulate mRNA targets through perfect pairing with their seed region (positions 2–7). Recently, a precise genome-wide map of miRNA interaction sites in mouse brain was generated by high-throughput sequencing and analysis of clusters of ~50-nucleotide mRNA tags cross-linked to Argonaute (Ago HITS-CLIP). By analyzing Ago HITS-CLIP 'orphan clusters'—Ago binding regions from HITS-CLIP that cannot be explained by canonical seed matches—we have now identified an alternative binding mode used by miRNAs. Specifically, G-bulge sites (positions 5–6) are often bound and regulated by miR-124 in brain. More generally, bulged sites comprise ≥15% of all Ago-miRNA interactions in mouse brain and are evolutionarily conserved. We call position 6 the 'pivot' nucleotide and suggest a model in which a transitional 'nucleation bulge' leads to functional bulge mRNA-miRNA interactions, expanding the number of potential miRNA regulatory sites.
         datePublished:2012-02-12T00:00:00Z
         dateModified:2012-02-12T00:00:00Z
         pageStart:321
         pageEnd:327
         sameAs:https://doi.org/10.1038/nsmb.2230
         keywords:
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            RNA metabolism
            Life Sciences
            general
            Biochemistry
            Protein Structure
            Membrane Biology
            Biological Microscopy
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      headline:An alternative mode of microRNA target recognition
      description:MicroRNAs are thought to repress mRNA targets through perfect pairing with their seed region, but a sizeable number of miRNA interaction sites are orphans, without a perfect canonical miRNA partner. Now a large number of miRNAs are found to use an alternative binding mode that involves the bulging out of an unpaired mRNA nucleotide, leading to a functional mRNA-miRNA interaction. MicroRNAs (miRNAs) regulate mRNA targets through perfect pairing with their seed region (positions 2–7). Recently, a precise genome-wide map of miRNA interaction sites in mouse brain was generated by high-throughput sequencing and analysis of clusters of ~50-nucleotide mRNA tags cross-linked to Argonaute (Ago HITS-CLIP). By analyzing Ago HITS-CLIP 'orphan clusters'—Ago binding regions from HITS-CLIP that cannot be explained by canonical seed matches—we have now identified an alternative binding mode used by miRNAs. Specifically, G-bulge sites (positions 5–6) are often bound and regulated by miR-124 in brain. More generally, bulged sites comprise ≥15% of all Ago-miRNA interactions in mouse brain and are evolutionarily conserved. We call position 6 the 'pivot' nucleotide and suggest a model in which a transitional 'nucleation bulge' leads to functional bulge mRNA-miRNA interactions, expanding the number of potential miRNA regulatory sites.
      datePublished:2012-02-12T00:00:00Z
      dateModified:2012-02-12T00:00:00Z
      pageStart:321
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         miRNAs
         RNA metabolism
         Life Sciences
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         Protein Structure
         Membrane Biology
         Biological Microscopy
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Social Networks {👍}(1)

External Links {🔗}(204)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
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CDN Services {📦}

  • Crossref

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