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We began analyzing https://www.nature.com/articles/nn.2167, but it redirected us to https://www.nature.com/articles/nn.2167. The analysis below is for the second page.

Title[redir]:
Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance | Nature Neuroscience
Description:
Neurons expressing Agouti-related protein (AgRP) and neuropeptide Y (NPY) in the hypothalamus are involved in regulation of feeding and body weight, but genetic disruption of AgRP and NPY have little effect on energy homeostasis. A new study from Tong et al. shows that the energy homeostasis function is mediated through their GABAergic transmission. The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron–specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.

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article, nature, cas, google, scholar, access, content, neurons, research, cookies, agrp, center, privacy, synaptic, release, gaba, obesity, data, information, energy, tong, lowell, hypothalamic, mice, open, nat, neurosci, medical, boston, supplementary, advertising, subscribe, neuroscience, communications, balance, jones, bradford, generated, institution, buy, cell, neuron, endocrinology, bbl, author, permissions, optional, media, personal, parties,

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nature portfolio permissions reprints privacy policy hypothalamic–pituitary–adrenal axis amelia hypothalamic research advertising lowell nature social media nature 411 nature 449 nature author information authors author correspondence npy-mediated synaptic plasticity personal data agrp-ires-cre mice springerlink instant access data protection permissions agrp neuron–specific deletion starvation stephan dodtnoah harvard medical school european economic area privacy communications article regulating energy balance communication published explore content subscription content hypothalamic neurocircuits agouti-related protein attenuated hyperphagic response issue learn institutional subscriptions read brain leptin action north american association electrophysiological recording studies accepting optional cookies journals search log young investigator award vgatflox/flox mice chian-ping ye article tong manage preferences vesicular gaba transporter agrp neurons content arcuate neurons energy balance https

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