NATURE . COM {}

Matching Content Categories {📚}

• Telecommunications
• Education
• Environment

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$531,700 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $354,480 to $974,820.

Keywords {🔍}

article, nature, cas, google, scholar, access, content, neurons, research, cookies, agrp, center, privacy, synaptic, release, gaba, obesity, data, information, energy, tong, lowell, hypothalamic, mice, open, nat, neurosci, medical, boston, supplementary, advertising, subscribe, neuroscience, communications, balance, jones, bradford, generated, institution, buy, cell, neuron, endocrinology, bbl, author, permissions, optional, media, personal, parties,

Topics {✒️}

nature portfolio permissions reprints privacy policy hypothalamic–pituitary–adrenal axis amelia hypothalamic research advertising lowell nature social media nature 411 nature 449 nature author information authors author correspondence npy-mediated synaptic plasticity personal data agrp-ires-cre mice springerlink instant access data protection permissions agrp neuron–specific deletion starvation stephan dodtnoah harvard medical school european economic area privacy communications article regulating energy balance communication published explore content subscription content hypothalamic neurocircuits agouti-related protein attenuated hyperphagic response issue learn institutional subscriptions read brain leptin action north american association electrophysiological recording studies accepting optional cookies journals search log young investigator award vgatflox/flox mice chian-ping ye article tong manage preferences vesicular gaba transporter agrp neurons content arcuate neurons energy balance https

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
         description:Neurons expressing Agouti-related protein (AgRP) and neuropeptide Y (NPY) in the hypothalamus are involved in regulation of feeding and body weight, but genetic disruption of AgRP and NPY have little effect on energy homeostasis. A new study from Tong et al. shows that the energy homeostasis function is mediated through their GABAergic transmission. The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron–specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.
         datePublished:2008-08-10T00:00:00Z
         dateModified:2008-08-10T00:00:00Z
         pageStart:998
         pageEnd:1000
         sameAs:https://doi.org/10.1038/nn.2167
         keywords:
            Biomedicine
            general
            Neurosciences
            Behavioral Sciences
            Biological Techniques
            Neurobiology
            Animal Genetics and Genomics
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.2167/MediaObjects/41593_2008_Article_BFnn2167_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.2167/MediaObjects/41593_2008_Article_BFnn2167_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.2167/MediaObjects/41593_2008_Article_BFnn2167_Fig3_HTML.jpg
         isPartOf:
            name:Nature Neuroscience
            issn:
               1546-1726
               1097-6256
            volumeNumber:11
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Qingchun Tong
               affiliation:
                     name:Beth Israel Deaconess Medical Center and Harvard Medical School
                     address:
                        name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chian-Ping Ye
               affiliation:
                     name:Beth Israel Deaconess Medical Center and Harvard Medical School
                     address:
                        name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Juli E Jones
               affiliation:
                     name:Beth Israel Deaconess Medical Center and Harvard Medical School
                     address:
                        name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Joel K Elmquist
               affiliation:
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bradford B Lowell
               affiliation:
                     name:Beth Israel Deaconess Medical Center and Harvard Medical School
                     address:
                        name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
      description:Neurons expressing Agouti-related protein (AgRP) and neuropeptide Y (NPY) in the hypothalamus are involved in regulation of feeding and body weight, but genetic disruption of AgRP and NPY have little effect on energy homeostasis. A new study from Tong et al. shows that the energy homeostasis function is mediated through their GABAergic transmission. The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron–specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.
      datePublished:2008-08-10T00:00:00Z
      dateModified:2008-08-10T00:00:00Z
      pageStart:998
      pageEnd:1000
      sameAs:https://doi.org/10.1038/nn.2167
      keywords:
         Biomedicine
         general
         Neurosciences
         Behavioral Sciences
         Biological Techniques
         Neurobiology
         Animal Genetics and Genomics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.2167/MediaObjects/41593_2008_Article_BFnn2167_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.2167/MediaObjects/41593_2008_Article_BFnn2167_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnn.2167/MediaObjects/41593_2008_Article_BFnn2167_Fig3_HTML.jpg
      isPartOf:
         name:Nature Neuroscience
         issn:
            1546-1726
            1097-6256
         volumeNumber:11
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Qingchun Tong
            affiliation:
                  name:Beth Israel Deaconess Medical Center and Harvard Medical School
                  address:
                     name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chian-Ping Ye
            affiliation:
                  name:Beth Israel Deaconess Medical Center and Harvard Medical School
                  address:
                     name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Juli E Jones
            affiliation:
                  name:Beth Israel Deaconess Medical Center and Harvard Medical School
                  address:
                     name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joel K Elmquist
            affiliation:
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bradford B Lowell
            affiliation:
                  name:Beth Israel Deaconess Medical Center and Harvard Medical School
                  address:
                     name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Neuroscience
      issn:
         1546-1726
         1097-6256
      volumeNumber:11
Organization:
      name:Nature Publishing Group US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Beth Israel Deaconess Medical Center and Harvard Medical School
      address:
         name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Beth Israel Deaconess Medical Center and Harvard Medical School
      address:
         name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
         type:PostalAddress
      name:Beth Israel Deaconess Medical Center and Harvard Medical School
      address:
         name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
      name:Beth Israel Deaconess Medical Center and Harvard Medical School
      address:
         name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Qingchun Tong
      affiliation:
            name:Beth Israel Deaconess Medical Center and Harvard Medical School
            address:
               name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Chian-Ping Ye
      affiliation:
            name:Beth Israel Deaconess Medical Center and Harvard Medical School
            address:
               name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Juli E Jones
      affiliation:
            name:Beth Israel Deaconess Medical Center and Harvard Medical School
            address:
               name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      name:Joel K Elmquist
      affiliation:
            name:University of Texas Southwestern Medical Center
            address:
               name:Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      name:Bradford B Lowell
      affiliation:
            name:Beth Israel Deaconess Medical Center and Harvard Medical School
            address:
               name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
      name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
      name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
      name:Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(1)

• https://twitter.com/natureneuro

External Links {🔗}(54)

• How much does https://link.springer.com/article/10.1038/nn.2167?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle pull in?
• What are the total earnings of https://doi.org/10.1096%2Ffj.04-3434fje?
• Income figures for http://scholar.google.com/scholar_lookup?&title=&journal=FASEB%20J.&doi=10.1096%2Ffj.04-3434fje&volume=19&pages=1680-1682&publication_year=2005&author=Bewick%2CGA
• What's the financial outcome of https://doi.org/10.1038%2Fnn1548?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=&journal=Nat.%20Neurosci.&doi=10.1038%2Fnn1548&volume=8&pages=1289-1291&publication_year=2005&author=Gropp%2CE
• How much money does https://doi.org/10.1126%2Fscience.1115524 generate?
• What's the income generated by http://scholar.google.com/scholar_lookup?&title=&journal=Science&doi=10.1126%2Fscience.1115524&volume=310&pages=683-685&publication_year=2005&author=Luquet%2CS&author=Perez%2CFA&author=Hnasko%2CTS&author=Palmiter%2CRD each month?
• How much money does https://doi.org/10.1128%2FMCB.22.14.5027-5035.2002 generate?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.22.14.5027-5035.2002&volume=22&pages=5027-5035&publication_year=2002&author=Qian%2CS rake in every month?
• Check the income stats for https://doi.org/10.1016%2Fj.cmet.2006.01.003
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=&journal=Cell%20Metab.&doi=10.1016%2Fj.cmet.2006.01.003&volume=3&pages=83-85&publication_year=2006&author=Flier%2CJS
• How much does https://doi.org/10.1016%2Fj.neuron.2004.06.004 pull in?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=&journal=Neuron&doi=10.1016%2Fj.neuron.2004.06.004&volume=42&pages=983-991&publication_year=2004&author=Balthasar%2CN?
• What is the earnings of https://doi.org/10.1038%2F35078085?
• Find out how much http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F35078085&volume=411&pages=480-484&publication_year=2001&author=Cowley%2CMA earns monthly
• What's the total monthly financial gain of https://doi.org/10.1016%2Fj.neuron.2006.04.016?
• Profit of http://scholar.google.com/scholar_lookup?&title=&journal=Neuron&doi=10.1016%2Fj.neuron.2006.04.016&volume=50&pages=575-587&publication_year=2006&author=Wojcik%2CSM
• How much does https://doi.org/10.1002%2F1526-968X%28200011%2F12%2928%3A3%2F4%3C147%3A%3AAID-GENE90%3E3.0.CO%3B2-G generate monthly?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=&journal=Genesis&doi=10.1002%2F1526-968X%28200011%2F12%2928%3A3%2F4%3C147%3A%3AAID-GENE90%3E3.0.CO%3B2-G&volume=28&pages=147-155&publication_year=2000&author=Novak%2CA&author=Guo%2CC&author=Yang%2CW&author=Nagy%2CA&author=Lobe%2CCG?
• What's the monthly income of https://doi.org/10.1016%2Fj.cmet.2007.04.001?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Cell%20Metab.&doi=10.1016%2Fj.cmet.2007.04.001&volume=5&pages=383-393&publication_year=2007&author=Tong%2CQ pull in?
• Get to know what's the income of https://doi.org/10.1210%2Fen.2003-1596
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Endocrinology&doi=10.1210%2Fen.2003-1596&volume=145&pages=2607-2612&publication_year=2004&author=Chen%2CHY pull in monthly?
• What's the income generated by https://doi.org/10.1038%2Fnature06098 each month?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2Fnature06098&volume=449&pages=228-232&publication_year=2007&author=Parton%2CLE?
• Revenue of https://doi.org/10.1016%2FS0896-6273%2803%2900063-1
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=&journal=Neuron&doi=10.1016%2FS0896-6273%2803%2900063-1&volume=37&pages=649-661&publication_year=2003&author=Cowley%2CMA?
• Revenue of https://doi.org/10.1038%2Fnn1455
• What's http://scholar.google.com/scholar_lookup?&title=&journal=Nat.%20Neurosci.&doi=10.1038%2Fnn1455&volume=8&pages=571-578&publication_year=2005&author=Cone%2CRD's gross income?
• Learn how profitable https://doi.org/10.1016%2Fj.peptides.2006.08.036 is on a monthly basis
• How much revenue does http://scholar.google.com/scholar_lookup?&title=&journal=Peptides&doi=10.1016%2Fj.peptides.2006.08.036&volume=28&pages=214-225&publication_year=2007&author=Luquet%2CS&author=Phillips%2CCT&author=Palmiter%2CRD bring in?
• How much profit is https://citation-needed.springer.com/v2/references/10.1038/nn.2167?format=refman&flavour=references making per month?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Qingchun%20Tong generate monthly?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Qingchun%20Tong%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
• What's https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Chian-Ping%20Ye's gross income?
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Chian-Ping%20Ye%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
• What's the financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Juli%20E%20Jones?
• https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Juli%20E%20Jones%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
• How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Joel%20K%20Elmquist generate?
• Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Joel%20K%20Elmquist%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Bradford%20B%20Lowell's financial summary
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bradford%20B%20Lowell%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
• See how much https://static-content.springer.com/esm/art%3A10.1038%2Fnn.2167/MediaObjects/41593_2008_BFnn2167_MOESM7_ESM.pdf makes per month
• Revenue of https://s100.copyright.com/AppDispatchServlet?title=Synaptic%20release%20of%20GABA%20by%20AgRP%20neurons%20is%20required%20for%20normal%20regulation%20of%20energy%20balance&author=Qingchun%20Tong%20et%20al&contentID=10.1038%2Fnn.2167©right=Springer%20Nature%20America%2C%20Inc.&publication=1097-6256&publicationDate=2008-08-10&publisherName=SpringerNature&orderBeanReset=true
• How much does https://citation-needed.springer.com/v2/references/10.1038/nn.2167?format=refman&flavour=citation bring in each month?
• How much does https://doi.org/10.1038/s41467-024-49766-0 earn?
• What's the financial outcome of https://doi.org/10.1007/s12020-024-03755-x?
• What's the monthly income of https://doi.org/10.1038/s41467-023-40082-7?
• See how much https://doi.org/10.1038/s41586-023-06358-0 makes per month
• How much does https://doi.org/10.1038/s41380-022-01872-5 bring in each month?
• Discover the revenue of https://www.protocols.io/
• How much does https://www.natureindex.com/ earn?
• What's the financial intake of http://www.naturechina.com?
• Monthly income for https://www.natureasia.com/ja-jp

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref