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Title[redir]:
Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses | Nature Immunology
Description:
Nature Immunology - IgA is essential in the maintenance of mucosal host defense and intestinal homeostasis. Stockinger and colleagues show that TH17 cells acquire a follicular helper T cell...
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pubmed, article, cas, google, scholar, cells, nature, central, cell, immunol, helper, iga, follicular, immunology, nat, immunity, research, gut, access, content, intestinal, receptor, plasticity, lymphoid, mice, center, medical, essential, cookies, responses, differentiation, privacy, function, peyers, patches, induction, celldependent, hirota, development, germinal, production, regulatory, med, mucosal, immune, foxp, proc, natl, acad, sci,
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nature portfolio permissions reprints privacy policy biological services advertising social media dual nature merck research laboratories japan nature 481 nature 448 nature 475 nature 453 nature content high-affinity iga cell-independent iga synthesis iga-producing germinal center identifying foxp3-expressing suppressor author correspondence interferon-driven immune dysregulation lymphoid organ development medical research cell–dependent iga responses personal data springerlink instant access data protection regulatory cell-iga response permissions article hirota lymphoid development transcriptional repressor bcl6 cell–dependent iga european economic area germinal center response physiologically normal state privacy icos receptor instructs cell–dependent immunoglobulin molecular immunology cells expressing foxp3 nuclear receptor rorγ present address competing financial interests foxp3+ follicular regulatory interleukin 17-producing effector th17 cell plasticity intestinal th17 cells mucoepithelial bacterial infection follicular helper cd4 adaptive immune regulation
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headline:Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cellâdependent IgA responses
description:IgA is essential in the maintenance of mucosal host defense and intestinal homeostasis. Stockinger and colleagues show that TH17 cells acquire a follicular helper T cell phenotype in Peyer's patches and induce the development of IgA-producing B cells. Intestinal Peyer's patches are essential lymphoid organs for the generation of T cellâdependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the TH17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such TH17 cells acquired a follicular helper T cell (TFH cell) phenotype and induced the development of IgA-producing germinal center B cells. Mice deficient in TH17 cells failed to generate antigen-specific IgA responses, which provides evidence that TH17 cells are the crucial subset required for the production of high-affinity T cellâdependent IgA.
datePublished:2013-03-10T00:00:00Z
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Immunology
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Biomedicine
general
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headline:Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cellâdependent IgA responses
description:IgA is essential in the maintenance of mucosal host defense and intestinal homeostasis. Stockinger and colleagues show that TH17 cells acquire a follicular helper T cell phenotype in Peyer's patches and induce the development of IgA-producing B cells. Intestinal Peyer's patches are essential lymphoid organs for the generation of T cellâdependent immunoglobulin A (IgA) for gut homeostasis. Through the use of interleukin 17 (IL-17) fate-reporter mice, we found here that endogenous cells of the TH17 subset of helper T cells in lymphoid organs of naive mice 'preferentially' homed to the intestines and were maintained independently of IL-23. In Peyer's patches, such TH17 cells acquired a follicular helper T cell (TFH cell) phenotype and induced the development of IgA-producing germinal center B cells. Mice deficient in TH17 cells failed to generate antigen-specific IgA responses, which provides evidence that TH17 cells are the crucial subset required for the production of high-affinity T cellâdependent IgA.
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