Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://www.nature.com/articles/nature25434, but it redirected us to https://www.nature.com/articles/nature25434. The analysis below is for the second page.

Title[redir]:
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation | Nature
Description:
A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level. Messenger RNA (mRNA) can be modified biochemically without changing its ribonucleotide sequence. These mRNA modifications are essential for post-transcriptional regulation of gene expression. Xuetao Cao and colleagues report the oxidation of the RNA base 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC) by the mammalian Tet2 enzyme. The authors also show that Tet2 promotes infection-induced myelopoiesis—generation of innate immune cells from the bone marrow—in mice. This effect occurs through a mechanism involving the destabilization of Socs3 mRNA caused by decreased levels of 5-mC. These findings highlight the role of epitranscriptome modifications in mammalian physiology. Varieties of RNA modification form the epitranscriptome for post-transcriptional regulation1. 5-Methylcytosine (5-mC) is a sparse RNA modification in messenger RNA (mRNA) under physiological conditions2. The function of RNA 5-hydroxymethylcytosine (5-hmC) oxidized by ten-eleven translocation (Tet) proteins in Drosophila has been revealed more recently3,4. However, the turnover and function of 5-mC in mammalian mRNA have been largely unknown. Tet2 suppresses myeloid malignancies mostly in an enzymatic activity-dependent manner5, and is important in resolving inflammatory response in an enzymatic activity-independent way6. Myelopoiesis is a common host immune response in acute and chronic infections; however, its epigenetic mechanism needs to be identified. Here we demonstrate that Tet2 promotes infection-induced myelopoiesis in an mRNA oxidation-dependent manner through Adar1-mediated repression of Socs3 expression at the post-transcription level. Tet2 promotes both abdominal sepsis-induced emergency myelopoiesis and parasite-induced mast cell expansion through decreasing mRNA levels of Socs3, a key negative regulator of the JAK–STAT pathway that is critical for cytokine-induced myelopoiesis. Tet2 represses Socs3 expression through Adar1, which binds and destabilizes Socs3 mRNA in a RNA editing-independent manner. For the underlying mechanism of Tet2 regulation at the mRNA level, Tet2 mediates oxidation of 5-mC in mRNA. Tet2 deficiency leads to the transcriptome-wide appearance of methylated cytosines, including ones in the 3′ untranslated region of Socs3, which influences double-stranded RNA formation for Adar1 binding, probably through cytosine methylation-specific readers, such as RNA helicases. Our study reveals a previously unknown regulatory role of Tet2 at the epitranscriptomic level, promoting myelopoiesis during infection in the mammalian system by decreasing 5-mCs in mRNAs. Moreover, the inhibitory function of cytosine methylation on double-stranded RNA formation and Adar1 binding in mRNA reveals its new physiological role in the mammalian system.

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We don't see any clear sign of profit-making.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Doi.org might be earning cash quietly, but we haven't detected the monetization method.

Keywords {🔍}

pubmed, data, article, cas, google, scholar, tet, rna, mrna, socs, nature, cells, central, source, bmmcs, adar, methylation, extended, analysis, levels, knockout, cell, nat, wildtype, fig, rnas, access, sequencing, oxidation, expression, control, clip, tetdeficient, replicates, cytosine, editing, hekt, mrnas, experiments, mice, figure, promotes, zhang, gene, ads, immunoblot, content, myelopoiesis, methylcytosine, modifications,

Topics {✒️}

kitw-sh/w-sh mice transplanted nature portfolio journals permissions reprints nature portfolio privacy policy clip library preparation advertising anti-5-mc immuno-selected rnas anti-adar1 immunoprecipitated wild-type social media rna editing-independent manner rna editing-related experiments cancer development decay-promoting rna-binding proteins j2 immuno-selected dsrna tet2-overexpressed hek293t cells myc-tagged tet2 mutants double-stranded rna formation enzymatic activity-dependent manner5 nature+ nature 525 nature 392 nature 502 nature 421 dynamic n1-methyladenosine methylome nature 554 nature nonsense-mediated mrna decay robust transcriptome-wide discovery cytosine methylation-specific readers mrna oxidation-dependent manner high-throughput sequencing data enzymatic activity-independent way6 tet-mediated 5mc oxidation shanghai rising-star program basophil development exon-located clip peak author correspondence vivo protein–rna interactions post-transcriptional gene regulation tet-assisted bisulfite sequencing bisulfite-pcr sequencing assay nsun2-mediated cytosine-5 methylation mc-supporting read numbers rt–pcr sequencing assay extended data figures springerlink instant access permissions cytokine-induced myelopoiesis myc-tagged tet2

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation
         description:A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level. Messenger RNA (mRNA) can be modified biochemically without changing its ribonucleotide sequence. These mRNA modifications are essential for post-transcriptional regulation of gene expression. Xuetao Cao and colleagues report the oxidation of the RNA base 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC) by the mammalian Tet2 enzyme. The authors also show that Tet2 promotes infection-induced myelopoiesis—generation of innate immune cells from the bone marrow—in mice. This effect occurs through a mechanism involving the destabilization of Socs3 mRNA caused by decreased levels of 5-mC. These findings highlight the role of epitranscriptome modifications in mammalian physiology. Varieties of RNA modification form the epitranscriptome for post-transcriptional regulation1. 5-Methylcytosine (5-mC) is a sparse RNA modification in messenger RNA (mRNA) under physiological conditions2. The function of RNA 5-hydroxymethylcytosine (5-hmC) oxidized by ten-eleven translocation (Tet) proteins in Drosophila has been revealed more recently3,4. However, the turnover and function of 5-mC in mammalian mRNA have been largely unknown. Tet2 suppresses myeloid malignancies mostly in an enzymatic activity-dependent manner5, and is important in resolving inflammatory response in an enzymatic activity-independent way6. Myelopoiesis is a common host immune response in acute and chronic infections; however, its epigenetic mechanism needs to be identified. Here we demonstrate that Tet2 promotes infection-induced myelopoiesis in an mRNA oxidation-dependent manner through Adar1-mediated repression of Socs3 expression at the post-transcription level. Tet2 promotes both abdominal sepsis-induced emergency myelopoiesis and parasite-induced mast cell expansion through decreasing mRNA levels of Socs3, a key negative regulator of the JAK–STAT pathway that is critical for cytokine-induced myelopoiesis. Tet2 represses Socs3 expression through Adar1, which binds and destabilizes Socs3 mRNA in a RNA editing-independent manner. For the underlying mechanism of Tet2 regulation at the mRNA level, Tet2 mediates oxidation of 5-mC in mRNA. Tet2 deficiency leads to the transcriptome-wide appearance of methylated cytosines, including ones in the 3′ untranslated region of Socs3, which influences double-stranded RNA formation for Adar1 binding, probably through cytosine methylation-specific readers, such as RNA helicases. Our study reveals a previously unknown regulatory role of Tet2 at the epitranscriptomic level, promoting myelopoiesis during infection in the mammalian system by decreasing 5-mCs in mRNAs. Moreover, the inhibitory function of cytosine methylation on double-stranded RNA formation and Adar1 binding in mRNA reveals its new physiological role in the mammalian system.
         datePublished:2018-01-24T00:00:00Z
         dateModified:2018-01-24T00:00:00Z
         pageStart:123
         pageEnd:127
         sameAs:https://doi.org/10.1038/nature25434
         keywords:
            Inflammation
            Innate immunity
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature25434/MediaObjects/41586_2018_Article_BFnature25434_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature25434/MediaObjects/41586_2018_Article_BFnature25434_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature25434/MediaObjects/41586_2018_Article_BFnature25434_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature25434/MediaObjects/41586_2018_Article_BFnature25434_Fig4_HTML.jpg
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:554
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Qicong Shen
               affiliation:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                     address:
                        name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qian Zhang
               affiliation:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                     address:
                        name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                        type:PostalAddress
                     type:Organization
                     name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                     address:
                        name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yang Shi
               affiliation:
                     name:Institute of Immunology, Zhejiang University School of Medicine
                     address:
                        name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qingzhu Shi
               affiliation:
                     name:Institute of Immunology, Zhejiang University School of Medicine
                     address:
                        name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yanyan Jiang
               affiliation:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                     address:
                        name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yan Gu
               affiliation:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                     address:
                        name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhiqing Li
               affiliation:
                     name:Institute of Immunology, Zhejiang University School of Medicine
                     address:
                        name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xia Li
               affiliation:
                     name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                     address:
                        name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kai Zhao
               affiliation:
                     name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                     address:
                        name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Chunmei Wang
               affiliation:
                     name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                     address:
                        name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nan Li
               affiliation:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                     address:
                        name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xuetao Cao
               affiliation:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                     address:
                        name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                        type:PostalAddress
                     type:Organization
                     name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                     address:
                        name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation
      description:A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level. Messenger RNA (mRNA) can be modified biochemically without changing its ribonucleotide sequence. These mRNA modifications are essential for post-transcriptional regulation of gene expression. Xuetao Cao and colleagues report the oxidation of the RNA base 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC) by the mammalian Tet2 enzyme. The authors also show that Tet2 promotes infection-induced myelopoiesis—generation of innate immune cells from the bone marrow—in mice. This effect occurs through a mechanism involving the destabilization of Socs3 mRNA caused by decreased levels of 5-mC. These findings highlight the role of epitranscriptome modifications in mammalian physiology. Varieties of RNA modification form the epitranscriptome for post-transcriptional regulation1. 5-Methylcytosine (5-mC) is a sparse RNA modification in messenger RNA (mRNA) under physiological conditions2. The function of RNA 5-hydroxymethylcytosine (5-hmC) oxidized by ten-eleven translocation (Tet) proteins in Drosophila has been revealed more recently3,4. However, the turnover and function of 5-mC in mammalian mRNA have been largely unknown. Tet2 suppresses myeloid malignancies mostly in an enzymatic activity-dependent manner5, and is important in resolving inflammatory response in an enzymatic activity-independent way6. Myelopoiesis is a common host immune response in acute and chronic infections; however, its epigenetic mechanism needs to be identified. Here we demonstrate that Tet2 promotes infection-induced myelopoiesis in an mRNA oxidation-dependent manner through Adar1-mediated repression of Socs3 expression at the post-transcription level. Tet2 promotes both abdominal sepsis-induced emergency myelopoiesis and parasite-induced mast cell expansion through decreasing mRNA levels of Socs3, a key negative regulator of the JAK–STAT pathway that is critical for cytokine-induced myelopoiesis. Tet2 represses Socs3 expression through Adar1, which binds and destabilizes Socs3 mRNA in a RNA editing-independent manner. For the underlying mechanism of Tet2 regulation at the mRNA level, Tet2 mediates oxidation of 5-mC in mRNA. Tet2 deficiency leads to the transcriptome-wide appearance of methylated cytosines, including ones in the 3′ untranslated region of Socs3, which influences double-stranded RNA formation for Adar1 binding, probably through cytosine methylation-specific readers, such as RNA helicases. Our study reveals a previously unknown regulatory role of Tet2 at the epitranscriptomic level, promoting myelopoiesis during infection in the mammalian system by decreasing 5-mCs in mRNAs. Moreover, the inhibitory function of cytosine methylation on double-stranded RNA formation and Adar1 binding in mRNA reveals its new physiological role in the mammalian system.
      datePublished:2018-01-24T00:00:00Z
      dateModified:2018-01-24T00:00:00Z
      pageStart:123
      pageEnd:127
      sameAs:https://doi.org/10.1038/nature25434
      keywords:
         Inflammation
         Innate immunity
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature25434/MediaObjects/41586_2018_Article_BFnature25434_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature25434/MediaObjects/41586_2018_Article_BFnature25434_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature25434/MediaObjects/41586_2018_Article_BFnature25434_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fnature25434/MediaObjects/41586_2018_Article_BFnature25434_Fig4_HTML.jpg
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:554
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Qicong Shen
            affiliation:
                  name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                  address:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qian Zhang
            affiliation:
                  name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                  address:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                     type:PostalAddress
                  type:Organization
                  name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                  address:
                     name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yang Shi
            affiliation:
                  name:Institute of Immunology, Zhejiang University School of Medicine
                  address:
                     name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qingzhu Shi
            affiliation:
                  name:Institute of Immunology, Zhejiang University School of Medicine
                  address:
                     name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yanyan Jiang
            affiliation:
                  name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                  address:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yan Gu
            affiliation:
                  name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                  address:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhiqing Li
            affiliation:
                  name:Institute of Immunology, Zhejiang University School of Medicine
                  address:
                     name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xia Li
            affiliation:
                  name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                  address:
                     name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kai Zhao
            affiliation:
                  name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                  address:
                     name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Chunmei Wang
            affiliation:
                  name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                  address:
                     name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nan Li
            affiliation:
                  name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                  address:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xuetao Cao
            affiliation:
                  name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
                  address:
                     name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
                     type:PostalAddress
                  type:Organization
                  name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
                  address:
                     name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:554
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
      address:
         name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
         type:PostalAddress
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
      address:
         name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
         type:PostalAddress
      name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
      address:
         name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
         type:PostalAddress
      name:Institute of Immunology, Zhejiang University School of Medicine
      address:
         name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
         type:PostalAddress
      name:Institute of Immunology, Zhejiang University School of Medicine
      address:
         name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
         type:PostalAddress
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
      address:
         name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
         type:PostalAddress
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
      address:
         name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
         type:PostalAddress
      name:Institute of Immunology, Zhejiang University School of Medicine
      address:
         name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
         type:PostalAddress
      name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
      address:
         name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
         type:PostalAddress
      name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
      address:
         name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
         type:PostalAddress
      name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
      address:
         name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
         type:PostalAddress
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
      address:
         name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
         type:PostalAddress
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
      address:
         name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
         type:PostalAddress
      name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
      address:
         name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Qicong Shen
      affiliation:
            name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
            address:
               name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Qian Zhang
      affiliation:
            name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
            address:
               name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
               type:PostalAddress
            type:Organization
            name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
            address:
               name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Yang Shi
      affiliation:
            name:Institute of Immunology, Zhejiang University School of Medicine
            address:
               name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Qingzhu Shi
      affiliation:
            name:Institute of Immunology, Zhejiang University School of Medicine
            address:
               name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Yanyan Jiang
      affiliation:
            name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
            address:
               name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Yan Gu
      affiliation:
            name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
            address:
               name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Zhiqing Li
      affiliation:
            name:Institute of Immunology, Zhejiang University School of Medicine
            address:
               name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
               type:PostalAddress
            type:Organization
      name:Xia Li
      affiliation:
            name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
            address:
               name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Kai Zhao
      affiliation:
            name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
            address:
               name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Chunmei Wang
      affiliation:
            name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
            address:
               name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      name:Nan Li
      affiliation:
            name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
            address:
               name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Xuetao Cao
      affiliation:
            name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University
            address:
               name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
               type:PostalAddress
            type:Organization
            name:Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences
            address:
               name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
      name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
      name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
      name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
      name:Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
      name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
      name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
      name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
      name:National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China
      name:Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

External Links {🔗}(349)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

4.67s.