
NATURE . COM {
}
Title:
E-cadherin germline mutations in familial gastric cancer | Nature
Description:
The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer death worldwide1, and about 10% of cases show familial clustering2,3. The relative contributions of inherited susceptibility and environmental effects to familial gastric cancer are poorly understood because little is known of the genetic events that predispose to gastric cancer. Here we describe the identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer4 in a large kindred from New Zealand (Aotearoa). Genetic linkage analysis demonstrated significant linkage to markers flanking the gene for the calcium-dependent cell–adhesion protein E-cadherin. Sequencing of the E-cadherin gene revealed a G→ T nucleotide substitution in the donor splice consensus sequence of exon 7, leading to a truncated gene product. Diminished E-cadherin expression is associated with aggressive, poorly differentiated carcinomas5. Underexpression of E-cadherin is a prognostic marker of poor clinical outcome in many tumour types6, and restored expression of E-cadherin in tumour models can suppress the invasiveness of epithelial tumour cells7,8. The role of E-cadherin in gastric cancer susceptibility was confirmed by identifying inactivating mutations in other gastric cancer families. In one family, a frameshift mutation was identified in exon 15, and in a second family a premature stop codon interrupted exon 13. These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Health & Fitness
- Photography
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $42,042 to $115,616.
Keywords {🔍}
cancer, article, google, scholar, cas, pubmed, ecadherin, gastric, nature, gene, mutations, access, human, cell, familial, zealand, content, cookies, diffuse, carcinoma, privacy, aotearoa, carcinomas, tumour, research, analysis, data, journal, guilford, hopkins, mcleod, clinical, genetic, linkage, expression, cells, invasion, open, dna, ads, central, res, advertising, information, subscribe, germline, parry, harraway, molecular, families,
Topics {✒️}
nature portfolio permissions reprints health research council privacy policy calcium-induced e-cadherin rigidification advertising e-cadherin invasion-suppressor gene social media subscribe nature nature genet author information authors nature 380 nature 392 nature e-cadherin gene revealed called intestinal-type carcinoma e-cadherin/catenin complex e-cadherin gene mutations e-cadherin germline mutations diminished e-cadherin expression microwave-based dna extraction author correspondence β catenin-tcf signalling personal data early-onset gastric cancer springerlink instant access histo-clinical classification data protection early invasion mediated permissions e-cadherin gene e-cadherin mutations e-cadherin expression cadherin gene superfamily human gynaecologic cancers privacy diffuse gastric cancer4 multilocus linkage analysis invasion suppressor role human genome based familial gastric cancer epithelial tumour cells7 gastric cancer remains truncated gene product myosin-viia gene poor clinical outcome human carinoma cells human genome database primary gastric carcinomas histological main types
Schema {🗺️}
WebPage:
mainEntity:
headline:E-cadherin germline mutations in familial gastric cancer
description:The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer death worldwide1, and about 10% of cases show familial clustering2,3. The relative contributions of inherited susceptibility and environmental effects to familial gastric cancer are poorly understood because little is known of the genetic events that predispose to gastric cancer. Here we describe the identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer4 in a large kindred from New Zealand (Aotearoa). Genetic linkage analysis demonstrated significant linkage to markers flanking the gene for the calcium-dependent cellâadhesion protein E-cadherin. Sequencing of the E-cadherin gene revealed a Gâ T nucleotide substitution in the donor splice consensus sequence of exon 7, leading to a truncated gene product. Diminished E-cadherin expression is associated with aggressive, poorly differentiated carcinomas5. Underexpression of E-cadherin is a prognostic marker of poor clinical outcome in many tumour types6, and restored expression of E-cadherin in tumour models can suppress the invasiveness of epithelial tumour cells7,8. The role of E-cadherin in gastric cancer susceptibility was confirmed by identifying inactivating mutations in other gastric cancer families. In one family, a frameshift mutation was identified in exon 15, and in a second family a premature stop codon interrupted exon 13. These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer.
datePublished:
dateModified:
pageStart:402
pageEnd:405
sameAs:https://doi.org/10.1038/32918
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig3_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:392
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Parry Guilford
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Justin Hopkins
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:James Harraway
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Maybelle McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Ngahiraka McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Pauline Harawira
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Huriana Taite
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Robin Scoular
affiliation:
name:Tauranga Public Hospital
address:
name:Tauranga Public Hospital, Tauranga, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Andrew Miller
affiliation:
name:University of Otago
address:
name:Pathology Department, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Anthony E. Reeve
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:E-cadherin germline mutations in familial gastric cancer
description:The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer death worldwide1, and about 10% of cases show familial clustering2,3. The relative contributions of inherited susceptibility and environmental effects to familial gastric cancer are poorly understood because little is known of the genetic events that predispose to gastric cancer. Here we describe the identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer4 in a large kindred from New Zealand (Aotearoa). Genetic linkage analysis demonstrated significant linkage to markers flanking the gene for the calcium-dependent cellâadhesion protein E-cadherin. Sequencing of the E-cadherin gene revealed a Gâ T nucleotide substitution in the donor splice consensus sequence of exon 7, leading to a truncated gene product. Diminished E-cadherin expression is associated with aggressive, poorly differentiated carcinomas5. Underexpression of E-cadherin is a prognostic marker of poor clinical outcome in many tumour types6, and restored expression of E-cadherin in tumour models can suppress the invasiveness of epithelial tumour cells7,8. The role of E-cadherin in gastric cancer susceptibility was confirmed by identifying inactivating mutations in other gastric cancer families. In one family, a frameshift mutation was identified in exon 15, and in a second family a premature stop codon interrupted exon 13. These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer.
datePublished:
dateModified:
pageStart:402
pageEnd:405
sameAs:https://doi.org/10.1038/32918
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig3_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:392
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Parry Guilford
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Justin Hopkins
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:James Harraway
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Maybelle McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Ngahiraka McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Pauline Harawira
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Huriana Taite
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Robin Scoular
affiliation:
name:Tauranga Public Hospital
address:
name:Tauranga Public Hospital, Tauranga, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Andrew Miller
affiliation:
name:University of Otago
address:
name:Pathology Department, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Anthony E. Reeve
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:392
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
name:Tauranga Public Hospital
address:
name:Tauranga Public Hospital, Tauranga, New Zealand
type:PostalAddress
name:University of Otago
address:
name:Pathology Department, University of Otago, Dunedin, New Zealand
type:PostalAddress
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Parry Guilford
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
email:[email protected]
name:Justin Hopkins
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
name:James Harraway
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
name:Maybelle McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
name:Ngahiraka McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
name:Pauline Harawira
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
name:Huriana Taite
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
name:Robin Scoular
affiliation:
name:Tauranga Public Hospital
address:
name:Tauranga Public Hospital, Tauranga, New Zealand
type:PostalAddress
type:Organization
name:Andrew Miller
affiliation:
name:University of Otago
address:
name:Pathology Department, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
name:Anthony E. Reeve
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
PostalAddress:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
name:Tauranga Public Hospital, Tauranga, New Zealand
name:Pathology Department, University of Otago, Dunedin, New Zealand
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(116)
- What's the monthly money flow for https://link.springer.com/article/10.1038/32918?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle?
- What are the total earnings of https://doi.org/10.1093%2Foxfordjournals.epirev.a036288?
- Explore the financials of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3533579
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=The%20decline%20in%20gastric%20cancer%3A%20Epidemiology%20of%20an%20unplanned%20triumph.&journal=Epidemiol.%20Rev.&doi=10.1093%2Foxfordjournals.epirev.a036288&volume=8&pages=1-27&publication_year=1986&author=Howson%2CCP&author=Hiyama%2CT&author=Wynder%2CEL?
- Learn about the earnings of https://doi.org/10.1002%2F1097-0142%2819920701%2970%3A1%3C50%3A%3AAID-CNCR2820700109%3E3.0.CO%3B2-I
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1606546 rake in every month?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Family%20history%20and%20the%20risk%20of%20stomach%20and%20colorectal%20cancer.&journal=Cancer&doi=10.1002%2F1097-0142%2819920701%2970%3A1%3C50%3A%3AAID-CNCR2820700109%3E3.0.CO%3B2-I&volume=70&pages=50-55&publication_year=1992&author=La%20Vecchia%2CC&author=Negri%2CE&author=Franceschi%2CS&author=Gentile%2CA generate?
- How much does https://doi.org/10.1002%2F1097-0142%2819901101%2966%3A9%3C2047%3A%3AAID-CNCR2820660934%3E3.0.CO%3B2-G earn?
- How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2224804 earning monthly?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Familial%20occurrence%20of%20gastric%20cancer%20in%20the%202-year%20experience%20of%20a%20population-based%20registry.&journal=Cancer&doi=10.1002%2F1097-0142%2819901101%2966%3A9%3C2047%3A%3AAID-CNCR2820660934%3E3.0.CO%3B2-G&volume=66&pages=2047-2051&publication_year=1990&author=Zanghieri%2CG?
- What's the financial outcome of https://doi.org/10.1111%2Fapm.1965.64.1.31?
- Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14320675 earns monthly
- http://scholar.google.com/scholar_lookup?&title=The%20two%20histological%20main%20types%20of%20gastric%20carcinoma%3A%20diffuse%20and%20so-called%20intestinal-type%20carcinoma.%20An%20attempt%20at%20a%20histo-clinical%20classification.&journal=Acta%20Pathol.%20Microbiol.%20Scand.&doi=10.1111%2Fapm.1965.64.1.31&volume=64&pages=31-49&publication_year=1965&author=Lauren%2CP income
- https://doi.org/10.1002%2F%28SICI%291097-0142%2819960415%2977%3A8%3C1605%3A%3AAID-CNCR28%3E3.0.CO%3B2-2's financial summary
- How much revenue does http://scholar.google.com/scholar_lookup?&title=E-cadherin%20mediated%20adhesion%20system%20in%20cancer%20cells.&journal=Cancer&doi=10.1002%2F%28SICI%291097-0142%2819960415%2977%3A8%3C1605%3A%3AAID-CNCR28%3E3.0.CO%3B2-2&volume=77&pages=1605-1613&publication_year=1995&author=Shiozaki%2CH&author=Oka%2CH&author=Inoue%2CM&author=Tamura%2CS&author=Monden%2CM produce monthly?
- http://scholar.google.com/scholar_lookup?&title=The%20E-cadherin%2Fcatenin%20complex%20in%20invasion%20and%20metastasis.&journal=Curr.%20Topics%20Microbiol.%20Imm.&volume=213&pages=123-161&publication_year=1996&author=Bracke%2CME&author=Roy%2CFM&author=Mareel%2CMM income
- What is the earnings of https://doi.org/10.1083%2Fjcb.113.1.173?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2007622's revenue stream
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=E-cadherin-mediated%20cell-cell%20adhesion%20prevents%20invasiveness%20of%20human%20carinoma%20cells.&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.113.1.173&volume=113&pages=173-185&publication_year=1991&author=Frixen%2CEH
- Monthly income for https://doi.org/10.1016%2F0092-8674%2891%2990143-M
- How much profit is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2070412 making per month?
- http://scholar.google.com/scholar_lookup?&title=Genetic%20manipulation%20of%20E-cadherin%20expression%20by%20epithelial%20tumour%20cells%20reveals%20an%20invasion%20suppressor%20role.&journal=Cell&doi=10.1016%2F0092-8674%2891%2990143-M&volume=66&pages=107-119&publication_year=1991&author=Vleminckx%2CK&author=Vakaet%2CL&author=Mareel%2CM&author=Fiers%2CW&author=Roy%2CFV income
- How much does http://scholar.google.com/scholar_lookup?&title=Familial%20gastric%20cancer.&journal=NZ%20Med.%20J.&volume=63&pages=287-296&publication_year=1964&author=Jones%2CEG pull in monthly?
- What are the total earnings of https://doi.org/10.1016%2F0955-0674%2893%2990028-O?
- What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8240823?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=The%20structural%20and%20functional%20analysis%20of%20cadherin%20calcium-dependent%20cell%20adhesion%20molecules.&journal=Curr.%20Opin.%20Cell%20Biol.&doi=10.1016%2F0955-0674%2893%2990028-O&volume=5&pages=797-805&publication_year=1993&author=Grunwald%2CGB
- Get to know what's the income of https://doi.org/10.1038%2F380152a0
- Financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1996Natur.380..152D
- Explore the financials of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8600387
- How much does http://scholar.google.com/scholar_lookup?&title=Acomprehensive%20genetic%20map%20of%20the%20human%20genome%20based%20on%205%2C264%20microsatellites.&journal=Nature&doi=10.1038%2F380152a0&volume=380&pages=152-154&publication_year=1996&author=Dib%2CC pull in monthly?
- Find out how much https://doi.org/10.1002%2Fj.1460-2075.1995.tb00301.x earns monthly
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8557030 produce monthly?
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC394735's financial summary
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=E-cadherin%20is%20a%20tumour%2Finvasion%20suppressor%20gene%20mutated%20in%20human%20lobular%20breast%20cancers.&journal=EMBO%20J.&doi=10.1002%2Fj.1460-2075.1995.tb00301.x&volume=14&pages=6107-6115&publication_year=1995&author=Berx%2CG?
- How much does https://doi.org/10.1146%2Fannurev.bi.55.070186.005351 net monthly?
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2943217?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Splicing%20of%20messenger%20RNA%20precursors.&journal=Annu.%20Rev.%20Biochem.&doi=10.1146%2Fannurev.bi.55.070186.005351&volume=55&pages=1119-1150&publication_year=1986&author=Padgett%2CRA&author=Grabowski%2CPJ&author=Konarska%2CMM&author=Seiler%2CS&author=Sharp%2CPA
- How much does https://doi.org/10.1038%2Fng0697-191 generate monthly?
- What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9171833?
- Earnings of http://scholar.google.com/scholar_lookup?&title=The%20autosomal%20recessive%20isolated%20deafness%2C%20DFNB2%2C%20and%20the%20Usher%201B%20syndrome%20are%20allelic%20defects%20of%20the%20myosin-VIIA%20gene.&journal=Nature%20Genet.&doi=10.1038%2Fng0697-191&volume=16&pages=191-193&publication_year=1997&author=Weil%2CD
- Profit of https://doi.org/10.1073%2Fpnas.91.5.1858
- Financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1994PNAS...91.1858O
- What's the financial outcome of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8127895?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC43263 pull in monthly?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=E-cadherin%20gene%20mutations%20in%20human%20gastric%20carcinoma%20cell%20lines.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.91.5.1858&volume=91&pages=1858-1862&publication_year=1994&author=Oda%2CT have monthly?
- Learn how profitable https://doi.org/10.1016%2F0888-7543%2895%2980212-5 is on a monthly basis
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7601454 pull in?
- How much does http://scholar.google.com/scholar_lookup?&title=Cloning%20and%20characterization%20of%20the%20human%20invasion%20supressor%20gene%20E-cadherin%20%28CDH1%29.&journal=Genomics&doi=10.1016%2F0888-7543%2895%2980212-5&volume=26&pages=281-289&publication_year=1995&author=Berx%2CG earn?
- How much cash flow does https://doi.org/10.1038%2F380360a0 have monthly?
- http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1996Natur.380..360N income
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8598933
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Structural%20basis%20of%20calcium-induced%20E-cadherin%20rigidification%20and%20imerization.&journal=Nature&doi=10.1038%2F380360a0&volume=380&pages=360-364&publication_year=1996&author=Nagar%2CB&author=Overduin%2CM&author=Ikura%2CM&author=Rini%2CJM?
- What's the total monthly financial gain of https://doi.org/10.1016%2F0092-8674%2891%2990359-7?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1959133 generate?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=The%20fat%20tumour%20suppressor%20gene%20in%20Drosophila%20encodes%20a%20novel%20member%20of%20the%20cadherin%20gene%20superfamily.&journal=Cell&doi=10.1016%2F0092-8674%2891%2990359-7&volume=67&pages=853-868&publication_year=1991&author=Mahoney%2CPA each month?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8033105 produce monthly?
- How much profit is http://scholar.google.com/scholar_lookup?&title=E-cadherin%20gene%20mutations%20provide%20clues%20to%20diffuse%20type%20gastric%20carcinomas.&journal=Cancer%20Res.&volume=54&pages=3845-3852&publication_year=1994&author=Becker%2CK-F making per month?
- How much income does https://doi.org/10.1111%2Fj.1349-7006.1996.tb02109.x have?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=E-cadherin%20mutations%20in%20signet%20ring%20cell%20carcinoma%20of%20the%20stomach.&journal=Jap.%20J.%20Cancer%20Res.&doi=10.1111%2Fj.1349-7006.1996.tb02109.x&volume=87&pages=843-848&publication_year=1996&author=Muta%2CH
- What is the monthly revenue of https://doi.org/10.1111%2Fj.1349-7006.1996.tb03125.x?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Inactivation%20of%20the%20E-cadherin%20gene%20in%20primary%20gastric%20carcinomas%20and%20gastric%20carcinoma%20cell%20lines.&journal=Jap.%20J.%20Cancer%20Res.&doi=10.1111%2Fj.1349-7006.1996.tb03125.x&volume=87&pages=1153-1159&publication_year=1996&author=Tamura%2CG?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8934538 generate?
- Revenue of http://scholar.google.com/scholar_lookup?&title=E-cadherin%20is%20inactivated%20in%20a%20majority%20of%20invasive%20human%20lobular%20breast%20cancers%20by%20truncation%20mutations%20throughout%20its%20extracellular%20domain.&journal=Oncogene&volume=13&pages=1919-1925&publication_year=1996&author=Berx%2CG
- Profit of https://doi.org/10.1038%2Fng0594-98
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8075649's revenue stream
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Mutations%20of%20the%20E-cadherin%20gene%20in%20human%20gynaecologic%20cancers.&journal=Nature%20Genet.&doi=10.1038%2Fng0594-98&volume=7&pages=98-102&publication_year=1994&author=Risinger%2CJI&author=Berchuck%2CA&author=Kohler%2CMF&author=Boyd%2CJ is on a monthly basis
- How much cash flow does https://doi.org/10.1073%2Fpnas.92.16.7416 have monthly?
- How much income does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1995PNAS...92.7416Y have?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7543680 bring in?
- What are the total earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC41350?
- What's the monthly money flow for http://scholar.google.com/scholar_lookup?&title=Silencing%20of%20the%20E-cadherin%20invasion-suppressor%20gene%20by%20CpG%20methylation%20in%20human%20carcinomas.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.92.16.7416&volume=92&pages=7416-7419&publication_year=1995&author=Yoshiura%2CK?
- How much profit is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7585573 making per month?
- http://scholar.google.com/scholar_lookup?&title=E-cadherin%20expression%20is%20silenced%20by%20DNA%20hypermethylation%20in%20human%20breast%20and%20prostate%20carcinomas.&journal=Cancer%20Res.&volume=55&pages=5195-5199&publication_year=1995&author=Graff%2CJR income
- How much money does https://doi.org/10.1126%2Fscience.275.5307.1787 make?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9065402 bring in?
- How much does http://scholar.google.com/scholar_lookup?&title=Activation%20of%20%CE%B2%20catenin-Tcf%20signalling%20in%20colon%20cancer%20mutations%20in%20%CE%B2%20catenin%20or%20APC.&journal=Science&doi=10.1126%2Fscience.275.5307.1787&volume=275&pages=1787-1792&publication_year=1997&author=Morin%2CPJ bring in each month?
- What's the revenue for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7619474?
- http://scholar.google.com/scholar_lookup?&title=Microwave-based%20DNA%20extraction%20from%20paraffin-embedded%20tissue%20for%20PCR%20amplification.&journal=Biotechniques&volume=18&pages=768-773&publication_year=1995&author=Banerjee%2CSK&author=Makdisi%2CWF&author=Weston%2CAP&author=Mitchell%2CSM&author=Campbell%2CDR income
- How much income is https://doi.org/10.1016%2F0003-2697%2887%2990021-2 earning monthly?
- Monthly income for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2440339
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Single-step%20method%20of%20RNA%20isolation%20by%20acid%20guanidinium%20thiocyanate-phenol-chloroform%20extraction.&journal=Analyt.%20Biochem.&doi=10.1016%2F0003-2697%2887%2990021-2&volume=162&pages=156-159&publication_year=1987&author=Chomczynski%2CP&author=Sacchi%2CN?
- Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3859205
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684598 gross monthly?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Multilocus%20linkage%20analysis%20in%20humans%3A%20Detection%20of%20linkage%20and%20estimation%20of%20recombination.&journal=Am.%20J.%20Hum.%20Genet.&volume=37&pages=482-498&publication_year=1985&author=Lathrop%2CGM&author=Lalouel%2CJM&author=Julier%2CC&author=Ott%2CJ make?
- Discover the revenue of https://citation-needed.springer.com/v2/references/10.1038/32918?format=refman&flavour=references
- What's the total monthly financial gain of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Parry%20Guilford?
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Parry%20Guilford%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Justin%20Hopkins generate monthly?
- What's the income generated by https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Justin%20Hopkins%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en each month?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=James%20Harraway pull in?
- Find out how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22James%20Harraway%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earns monthly
- Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Maybelle%20McLeod
- What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Maybelle%20McLeod%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ngahiraka%20McLeod earning monthly?
- What's the financial outcome of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ngahiraka%20McLeod%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the profit of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pauline%20Harawira?
- See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pauline%20Harawira%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
- How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Huriana%20Taite generate?
- Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Huriana%20Taite%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robin%20Scoular
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robin%20Scoular%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- What's the income of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Andrew%20Miller?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andrew%20Miller%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
- What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anthony%20E.%20Reeve?
- How much income does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anthony%20E.%20Reeve%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have?
- How much profit does https://s100.copyright.com/AppDispatchServlet?title=E-cadherin%20germline%20mutations%20in%20familial%20gastric%20cancer&author=Parry%20Guilford%20et%20al&contentID=10.1038%2F32918©right=Macmillan%20Magazines%20Ltd.&publication=0028-0836&publicationDate=1998-03-26&publisherName=SpringerNature&orderBeanReset=true make?
- What's the total monthly financial gain of https://citation-needed.springer.com/v2/references/10.1038/32918?format=refman&flavour=citation?
- What's the monthly money flow for https://doi.org/10.1007/s00535-024-02094-y?
- How much revenue does https://doi.org/10.1007/s10120-024-01504-7 bring in?
- How much cash flow does https://doi.org/10.1186/s12876-023-02822-3 have monthly?
- Income figures for https://doi.org/10.1186/s13046-023-02622-3
- What is the earnings of https://doi.org/10.1186/s12884-023-05772-6?
- How much does https://www.protocols.io/ bring in each month?
- Learn about the earnings of https://www.natureindex.com/
- How much cash flow does http://www.naturechina.com have monthly?
- How much money does https://www.natureasia.com/ja-jp generate?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref