
NATURE . COM {
}
Title:
E-cadherin germline mutations in familial gastric cancer | Nature
Description:
The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer death worldwide1, and about 10% of cases show familial clustering2,3. The relative contributions of inherited susceptibility and environmental effects to familial gastric cancer are poorly understood because little is known of the genetic events that predispose to gastric cancer. Here we describe the identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer4 in a large kindred from New Zealand (Aotearoa). Genetic linkage analysis demonstrated significant linkage to markers flanking the gene for the calcium-dependent cell–adhesion protein E-cadherin. Sequencing of the E-cadherin gene revealed a G→ T nucleotide substitution in the donor splice consensus sequence of exon 7, leading to a truncated gene product. Diminished E-cadherin expression is associated with aggressive, poorly differentiated carcinomas5. Underexpression of E-cadherin is a prognostic marker of poor clinical outcome in many tumour types6, and restored expression of E-cadherin in tumour models can suppress the invasiveness of epithelial tumour cells7,8. The role of E-cadherin in gastric cancer susceptibility was confirmed by identifying inactivating mutations in other gastric cancer families. In one family, a frameshift mutation was identified in exon 15, and in a second family a premature stop codon interrupted exon 13. These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Education
- Health & Fitness
- Photography
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌆 Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$531,700 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $354,480 to $974,820.
Keywords {🔍}
cancer, article, google, scholar, cas, pubmed, ecadherin, gastric, nature, gene, mutations, access, human, cell, familial, zealand, content, cookies, diffuse, carcinoma, privacy, aotearoa, carcinomas, tumour, research, analysis, data, journal, guilford, hopkins, mcleod, clinical, genetic, linkage, expression, cells, invasion, open, dna, ads, central, res, advertising, information, subscribe, germline, parry, harraway, molecular, families,
Topics {✒️}
nature portfolio permissions reprints health research council privacy policy calcium-induced e-cadherin rigidification advertising e-cadherin invasion-suppressor gene social media subscribe nature nature genet author information authors nature 380 nature 392 nature e-cadherin gene revealed called intestinal-type carcinoma e-cadherin/catenin complex e-cadherin gene mutations e-cadherin germline mutations diminished e-cadherin expression microwave-based dna extraction author correspondence β catenin-tcf signalling personal data early-onset gastric cancer springerlink instant access histo-clinical classification data protection early invasion mediated permissions e-cadherin gene e-cadherin mutations e-cadherin expression cadherin gene superfamily human gynaecologic cancers privacy diffuse gastric cancer4 multilocus linkage analysis invasion suppressor role human genome based familial gastric cancer epithelial tumour cells7 gastric cancer remains truncated gene product myosin-viia gene poor clinical outcome human carinoma cells human genome database primary gastric carcinomas histological main types
Schema {🗺️}
WebPage:
mainEntity:
headline:E-cadherin germline mutations in familial gastric cancer
description:The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer death worldwide1, and about 10% of cases show familial clustering2,3. The relative contributions of inherited susceptibility and environmental effects to familial gastric cancer are poorly understood because little is known of the genetic events that predispose to gastric cancer. Here we describe the identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer4 in a large kindred from New Zealand (Aotearoa). Genetic linkage analysis demonstrated significant linkage to markers flanking the gene for the calcium-dependent cellâadhesion protein E-cadherin. Sequencing of the E-cadherin gene revealed a Gâ T nucleotide substitution in the donor splice consensus sequence of exon 7, leading to a truncated gene product. Diminished E-cadherin expression is associated with aggressive, poorly differentiated carcinomas5. Underexpression of E-cadherin is a prognostic marker of poor clinical outcome in many tumour types6, and restored expression of E-cadherin in tumour models can suppress the invasiveness of epithelial tumour cells7,8. The role of E-cadherin in gastric cancer susceptibility was confirmed by identifying inactivating mutations in other gastric cancer families. In one family, a frameshift mutation was identified in exon 15, and in a second family a premature stop codon interrupted exon 13. These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer.
datePublished:
dateModified:
pageStart:402
pageEnd:405
sameAs:https://doi.org/10.1038/32918
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig3_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:392
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Parry Guilford
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Justin Hopkins
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:James Harraway
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Maybelle McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Ngahiraka McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Pauline Harawira
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Huriana Taite
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Robin Scoular
affiliation:
name:Tauranga Public Hospital
address:
name:Tauranga Public Hospital, Tauranga, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Andrew Miller
affiliation:
name:University of Otago
address:
name:Pathology Department, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Anthony E. Reeve
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:E-cadherin germline mutations in familial gastric cancer
description:The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer death worldwide1, and about 10% of cases show familial clustering2,3. The relative contributions of inherited susceptibility and environmental effects to familial gastric cancer are poorly understood because little is known of the genetic events that predispose to gastric cancer. Here we describe the identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer4 in a large kindred from New Zealand (Aotearoa). Genetic linkage analysis demonstrated significant linkage to markers flanking the gene for the calcium-dependent cellâadhesion protein E-cadherin. Sequencing of the E-cadherin gene revealed a Gâ T nucleotide substitution in the donor splice consensus sequence of exon 7, leading to a truncated gene product. Diminished E-cadherin expression is associated with aggressive, poorly differentiated carcinomas5. Underexpression of E-cadherin is a prognostic marker of poor clinical outcome in many tumour types6, and restored expression of E-cadherin in tumour models can suppress the invasiveness of epithelial tumour cells7,8. The role of E-cadherin in gastric cancer susceptibility was confirmed by identifying inactivating mutations in other gastric cancer families. In one family, a frameshift mutation was identified in exon 15, and in a second family a premature stop codon interrupted exon 13. These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer.
datePublished:
dateModified:
pageStart:402
pageEnd:405
sameAs:https://doi.org/10.1038/32918
keywords:
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2F32918/MediaObjects/41586_1998_Article_BF32918_Fig3_HTML.gif
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:392
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Parry Guilford
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Justin Hopkins
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:James Harraway
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Maybelle McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Ngahiraka McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Pauline Harawira
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Huriana Taite
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Robin Scoular
affiliation:
name:Tauranga Public Hospital
address:
name:Tauranga Public Hospital, Tauranga, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Andrew Miller
affiliation:
name:University of Otago
address:
name:Pathology Department, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
name:Anthony E. Reeve
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:392
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
name:Tauranga Public Hospital
address:
name:Tauranga Public Hospital, Tauranga, New Zealand
type:PostalAddress
name:University of Otago
address:
name:Pathology Department, University of Otago, Dunedin, New Zealand
type:PostalAddress
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Parry Guilford
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
email:[email protected]
name:Justin Hopkins
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
name:James Harraway
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
name:Maybelle McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
name:Ngahiraka McLeod
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
name:Pauline Harawira
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
name:Huriana Taite
affiliation:
name:Kimi Hauora Health Clinic
address:
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
type:PostalAddress
type:Organization
name:Robin Scoular
affiliation:
name:Tauranga Public Hospital
address:
name:Tauranga Public Hospital, Tauranga, New Zealand
type:PostalAddress
type:Organization
name:Andrew Miller
affiliation:
name:University of Otago
address:
name:Pathology Department, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
name:Anthony E. Reeve
affiliation:
name:Cancer Genetics Laboratory, University of Otago
address:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
type:PostalAddress
type:Organization
PostalAddress:
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
name:Kimi Hauora Health Clinic, Aotearoa, New Zealand
name:Tauranga Public Hospital, Tauranga, New Zealand
name:Pathology Department, University of Otago, Dunedin, New Zealand
name:Biochemistry Department, Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {🔗}(116)
- Revenue of https://link.springer.com/article/10.1038/32918?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
- What's https://doi.org/10.1093%2Foxfordjournals.epirev.a036288's gross income?
- Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3533579
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=The%20decline%20in%20gastric%20cancer%3A%20Epidemiology%20of%20an%20unplanned%20triumph.&journal=Epidemiol.%20Rev.&doi=10.1093%2Foxfordjournals.epirev.a036288&volume=8&pages=1-27&publication_year=1986&author=Howson%2CCP&author=Hiyama%2CT&author=Wynder%2CEL?
- How much does https://doi.org/10.1002%2F1097-0142%2819920701%2970%3A1%3C50%3A%3AAID-CNCR2820700109%3E3.0.CO%3B2-I generate monthly?
- Learn about the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1606546
- How profitable is http://scholar.google.com/scholar_lookup?&title=Family%20history%20and%20the%20risk%20of%20stomach%20and%20colorectal%20cancer.&journal=Cancer&doi=10.1002%2F1097-0142%2819920701%2970%3A1%3C50%3A%3AAID-CNCR2820700109%3E3.0.CO%3B2-I&volume=70&pages=50-55&publication_year=1992&author=La%20Vecchia%2CC&author=Negri%2CE&author=Franceschi%2CS&author=Gentile%2CA?
- Profit of https://doi.org/10.1002%2F1097-0142%2819901101%2966%3A9%3C2047%3A%3AAID-CNCR2820660934%3E3.0.CO%3B2-G
- See how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2224804 makes per month
- http://scholar.google.com/scholar_lookup?&title=Familial%20occurrence%20of%20gastric%20cancer%20in%20the%202-year%20experience%20of%20a%20population-based%20registry.&journal=Cancer&doi=10.1002%2F1097-0142%2819901101%2966%3A9%3C2047%3A%3AAID-CNCR2820660934%3E3.0.CO%3B2-G&volume=66&pages=2047-2051&publication_year=1990&author=Zanghieri%2CG's revenue stream
- How much income does https://doi.org/10.1111%2Fapm.1965.64.1.31 have?
- Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14320675
- Income figures for http://scholar.google.com/scholar_lookup?&title=The%20two%20histological%20main%20types%20of%20gastric%20carcinoma%3A%20diffuse%20and%20so-called%20intestinal-type%20carcinoma.%20An%20attempt%20at%20a%20histo-clinical%20classification.&journal=Acta%20Pathol.%20Microbiol.%20Scand.&doi=10.1111%2Fapm.1965.64.1.31&volume=64&pages=31-49&publication_year=1965&author=Lauren%2CP
- What's the income generated by https://doi.org/10.1002%2F%28SICI%291097-0142%2819960415%2977%3A8%3C1605%3A%3AAID-CNCR28%3E3.0.CO%3B2-2 each month?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=E-cadherin%20mediated%20adhesion%20system%20in%20cancer%20cells.&journal=Cancer&doi=10.1002%2F%28SICI%291097-0142%2819960415%2977%3A8%3C1605%3A%3AAID-CNCR28%3E3.0.CO%3B2-2&volume=77&pages=1605-1613&publication_year=1995&author=Shiozaki%2CH&author=Oka%2CH&author=Inoue%2CM&author=Tamura%2CS&author=Monden%2CM
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=The%20E-cadherin%2Fcatenin%20complex%20in%20invasion%20and%20metastasis.&journal=Curr.%20Topics%20Microbiol.%20Imm.&volume=213&pages=123-161&publication_year=1996&author=Bracke%2CME&author=Roy%2CFM&author=Mareel%2CMM each month?
- What's the monthly income of https://doi.org/10.1083%2Fjcb.113.1.173?
- Learn about the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2007622
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=E-cadherin-mediated%20cell-cell%20adhesion%20prevents%20invasiveness%20of%20human%20carinoma%20cells.&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.113.1.173&volume=113&pages=173-185&publication_year=1991&author=Frixen%2CEH have monthly?
- How much does https://doi.org/10.1016%2F0092-8674%2891%2990143-M gross monthly?
- What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2070412?
- What's the income of http://scholar.google.com/scholar_lookup?&title=Genetic%20manipulation%20of%20E-cadherin%20expression%20by%20epithelial%20tumour%20cells%20reveals%20an%20invasion%20suppressor%20role.&journal=Cell&doi=10.1016%2F0092-8674%2891%2990143-M&volume=66&pages=107-119&publication_year=1991&author=Vleminckx%2CK&author=Vakaet%2CL&author=Mareel%2CM&author=Fiers%2CW&author=Roy%2CFV?
- How much does http://scholar.google.com/scholar_lookup?&title=Familial%20gastric%20cancer.&journal=NZ%20Med.%20J.&volume=63&pages=287-296&publication_year=1964&author=Jones%2CEG generate monthly?
- What's the profit of https://doi.org/10.1016%2F0955-0674%2893%2990028-O?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8240823 income
- What's the profit of http://scholar.google.com/scholar_lookup?&title=The%20structural%20and%20functional%20analysis%20of%20cadherin%20calcium-dependent%20cell%20adhesion%20molecules.&journal=Curr.%20Opin.%20Cell%20Biol.&doi=10.1016%2F0955-0674%2893%2990028-O&volume=5&pages=797-805&publication_year=1993&author=Grunwald%2CGB?
- What's the total monthly financial gain of https://doi.org/10.1038%2F380152a0?
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1996Natur.380..152D make?
- What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8600387?
- How much profit is http://scholar.google.com/scholar_lookup?&title=Acomprehensive%20genetic%20map%20of%20the%20human%20genome%20based%20on%205%2C264%20microsatellites.&journal=Nature&doi=10.1038%2F380152a0&volume=380&pages=152-154&publication_year=1996&author=Dib%2CC making per month?
- How much revenue does https://doi.org/10.1002%2Fj.1460-2075.1995.tb00301.x generate?
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8557030 make?
- What's the revenue for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC394735?
- Earnings of http://scholar.google.com/scholar_lookup?&title=E-cadherin%20is%20a%20tumour%2Finvasion%20suppressor%20gene%20mutated%20in%20human%20lobular%20breast%20cancers.&journal=EMBO%20J.&doi=10.1002%2Fj.1460-2075.1995.tb00301.x&volume=14&pages=6107-6115&publication_year=1995&author=Berx%2CG
- How much revenue does https://doi.org/10.1146%2Fannurev.bi.55.070186.005351 generate?
- How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2943217 earning monthly?
- How much income is http://scholar.google.com/scholar_lookup?&title=Splicing%20of%20messenger%20RNA%20precursors.&journal=Annu.%20Rev.%20Biochem.&doi=10.1146%2Fannurev.bi.55.070186.005351&volume=55&pages=1119-1150&publication_year=1986&author=Padgett%2CRA&author=Grabowski%2CPJ&author=Konarska%2CMM&author=Seiler%2CS&author=Sharp%2CPA earning monthly?
- How much income does https://doi.org/10.1038%2Fng0697-191 have?
- What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9171833?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=The%20autosomal%20recessive%20isolated%20deafness%2C%20DFNB2%2C%20and%20the%20Usher%201B%20syndrome%20are%20allelic%20defects%20of%20the%20myosin-VIIA%20gene.&journal=Nature%20Genet.&doi=10.1038%2Fng0697-191&volume=16&pages=191-193&publication_year=1997&author=Weil%2CD?
- How much does https://doi.org/10.1073%2Fpnas.91.5.1858 gross monthly?
- What's http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1994PNAS...91.1858O's gross income?
- Learn how profitable http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8127895 is on a monthly basis
- How much profit does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC43263 generate?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=E-cadherin%20gene%20mutations%20in%20human%20gastric%20carcinoma%20cell%20lines.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.91.5.1858&volume=91&pages=1858-1862&publication_year=1994&author=Oda%2CT
- Learn how profitable https://doi.org/10.1016%2F0888-7543%2895%2980212-5 is on a monthly basis
- What's the income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7601454?
- Profit of http://scholar.google.com/scholar_lookup?&title=Cloning%20and%20characterization%20of%20the%20human%20invasion%20supressor%20gene%20E-cadherin%20%28CDH1%29.&journal=Genomics&doi=10.1016%2F0888-7543%2895%2980212-5&volume=26&pages=281-289&publication_year=1995&author=Berx%2CG
- https://doi.org/10.1038%2F380360a0's total income per month
- Learn how profitable http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1996Natur.380..360N is on a monthly basis
- Learn how profitable http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8598933 is on a monthly basis
- How much does http://scholar.google.com/scholar_lookup?&title=Structural%20basis%20of%20calcium-induced%20E-cadherin%20rigidification%20and%20imerization.&journal=Nature&doi=10.1038%2F380360a0&volume=380&pages=360-364&publication_year=1996&author=Nagar%2CB&author=Overduin%2CM&author=Ikura%2CM&author=Rini%2CJM make?
- Income figures for https://doi.org/10.1016%2F0092-8674%2891%2990359-7
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1959133 earn?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=The%20fat%20tumour%20suppressor%20gene%20in%20Drosophila%20encodes%20a%20novel%20member%20of%20the%20cadherin%20gene%20superfamily.&journal=Cell&doi=10.1016%2F0092-8674%2891%2990359-7&volume=67&pages=853-868&publication_year=1991&author=Mahoney%2CPA have monthly?
- How much cash flow does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8033105 have monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=E-cadherin%20gene%20mutations%20provide%20clues%20to%20diffuse%20type%20gastric%20carcinomas.&journal=Cancer%20Res.&volume=54&pages=3845-3852&publication_year=1994&author=Becker%2CK-F make?
- How much revenue does https://doi.org/10.1111%2Fj.1349-7006.1996.tb02109.x bring in?
- How much does http://scholar.google.com/scholar_lookup?&title=E-cadherin%20mutations%20in%20signet%20ring%20cell%20carcinoma%20of%20the%20stomach.&journal=Jap.%20J.%20Cancer%20Res.&doi=10.1111%2Fj.1349-7006.1996.tb02109.x&volume=87&pages=843-848&publication_year=1996&author=Muta%2CH make?
- What's the financial intake of https://doi.org/10.1111%2Fj.1349-7006.1996.tb03125.x?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Inactivation%20of%20the%20E-cadherin%20gene%20in%20primary%20gastric%20carcinomas%20and%20gastric%20carcinoma%20cell%20lines.&journal=Jap.%20J.%20Cancer%20Res.&doi=10.1111%2Fj.1349-7006.1996.tb03125.x&volume=87&pages=1153-1159&publication_year=1996&author=Tamura%2CG generate?
- What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8934538?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=E-cadherin%20is%20inactivated%20in%20a%20majority%20of%20invasive%20human%20lobular%20breast%20cancers%20by%20truncation%20mutations%20throughout%20its%20extracellular%20domain.&journal=Oncogene&volume=13&pages=1919-1925&publication_year=1996&author=Berx%2CG bring in?
- How much does https://doi.org/10.1038%2Fng0594-98 bring in each month?
- Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8075649's earnings
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Mutations%20of%20the%20E-cadherin%20gene%20in%20human%20gynaecologic%20cancers.&journal=Nature%20Genet.&doi=10.1038%2Fng0594-98&volume=7&pages=98-102&publication_year=1994&author=Risinger%2CJI&author=Berchuck%2CA&author=Kohler%2CMF&author=Boyd%2CJ?
- What's the profit of https://doi.org/10.1073%2Fpnas.92.16.7416?
- Income figures for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1995PNAS...92.7416Y
- How much income is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7543680 earning monthly?
- Explore the financials of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC41350
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Silencing%20of%20the%20E-cadherin%20invasion-suppressor%20gene%20by%20CpG%20methylation%20in%20human%20carcinomas.&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.92.16.7416&volume=92&pages=7416-7419&publication_year=1995&author=Yoshiura%2CK have monthly?
- Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7585573
- http://scholar.google.com/scholar_lookup?&title=E-cadherin%20expression%20is%20silenced%20by%20DNA%20hypermethylation%20in%20human%20breast%20and%20prostate%20carcinomas.&journal=Cancer%20Res.&volume=55&pages=5195-5199&publication_year=1995&author=Graff%2CJR's total income per month
- Get to know what's the income of https://doi.org/10.1126%2Fscience.275.5307.1787
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9065402 net monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Activation%20of%20%CE%B2%20catenin-Tcf%20signalling%20in%20colon%20cancer%20mutations%20in%20%CE%B2%20catenin%20or%20APC.&journal=Science&doi=10.1126%2Fscience.275.5307.1787&volume=275&pages=1787-1792&publication_year=1997&author=Morin%2CPJ net monthly?
- See how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=7619474 makes per month
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Microwave-based%20DNA%20extraction%20from%20paraffin-embedded%20tissue%20for%20PCR%20amplification.&journal=Biotechniques&volume=18&pages=768-773&publication_year=1995&author=Banerjee%2CSK&author=Makdisi%2CWF&author=Weston%2CAP&author=Mitchell%2CSM&author=Campbell%2CDR?
- How much does https://doi.org/10.1016%2F0003-2697%2887%2990021-2 rake in every month?
- What are the total earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2440339?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Single-step%20method%20of%20RNA%20isolation%20by%20acid%20guanidinium%20thiocyanate-phenol-chloroform%20extraction.&journal=Analyt.%20Biochem.&doi=10.1016%2F0003-2697%2887%2990021-2&volume=162&pages=156-159&publication_year=1987&author=Chomczynski%2CP&author=Sacchi%2CN?
- How profitable is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3859205?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684598 pull in?
- How much does http://scholar.google.com/scholar_lookup?&title=Multilocus%20linkage%20analysis%20in%20humans%3A%20Detection%20of%20linkage%20and%20estimation%20of%20recombination.&journal=Am.%20J.%20Hum.%20Genet.&volume=37&pages=482-498&publication_year=1985&author=Lathrop%2CGM&author=Lalouel%2CJM&author=Julier%2CC&author=Ott%2CJ net monthly?
- How much revenue does https://citation-needed.springer.com/v2/references/10.1038/32918?format=refman&flavour=references produce monthly?
- How much cash flow does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Parry%20Guilford have monthly?
- What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Parry%20Guilford%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Justin%20Hopkins
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Justin%20Hopkins%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
- What's the revenue for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=James%20Harraway?
- See how much https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22James%20Harraway%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en makes per month
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Maybelle%20McLeod make?
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Maybelle%20McLeod%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- How much income is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ngahiraka%20McLeod earning monthly?
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ngahiraka%20McLeod%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pauline%20Harawira
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pauline%20Harawira%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's financial summary
- How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Huriana%20Taite have?
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Huriana%20Taite%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- Explore the financials of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Robin%20Scoular
- What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Robin%20Scoular%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Andrew%20Miller
- Get to know what's the income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andrew%20Miller%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Anthony%20E.%20Reeve
- What's the monthly income of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Anthony%20E.%20Reeve%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- How much money does https://s100.copyright.com/AppDispatchServlet?title=E-cadherin%20germline%20mutations%20in%20familial%20gastric%20cancer&author=Parry%20Guilford%20et%20al&contentID=10.1038%2F32918©right=Macmillan%20Magazines%20Ltd.&publication=0028-0836&publicationDate=1998-03-26&publisherName=SpringerNature&orderBeanReset=true generate?
- Learn about the earnings of https://citation-needed.springer.com/v2/references/10.1038/32918?format=refman&flavour=citation
- How much does https://doi.org/10.1007/s00535-024-02094-y gross monthly?
- What's the revenue for https://doi.org/10.1007/s10120-024-01504-7?
- https://doi.org/10.1186/s12876-023-02822-3's total income per month
- What's the income generated by https://doi.org/10.1186/s13046-023-02622-3 each month?
- What's the financial intake of https://doi.org/10.1186/s12884-023-05772-6?
- How much money does https://www.protocols.io/ make?
- What is the monthly revenue of https://www.natureindex.com/?
- Learn how profitable http://www.naturechina.com is on a monthly basis
- Get to know https://www.natureasia.com/ja-jp's earnings
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref