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We began analyzing https://www.nature.com/articles/nn.3695, but it redirected us to https://www.nature.com/articles/nn.3695. The analysis below is for the second page.

Title[redir]:
Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice | Nature Neuroscience
Description:
In this study, the authors show that the heritable behavioral and metabolic changes that are observed in rodents exposed to early life stress are mediated by changes in miRNA levels in the sperm of affected males. Injection of isolated RNA from the sperm of stressed males into donor fertilized oocytes is able to induce these phenotypic changes in the resulting offspring. Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

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Keywords {🔍}

msus, article, control, google, scholar, cas, reads, nature, supplementary, rnas, mice, sperm, figure, data, adult, animals, mirp, access, rna, biol, sem, content, expression, males, zürich, libraries, cookies, neuroscience, mansuy, mouse, metabolic, sequencing, size, mapping, mirnas, msusrnainj, privacy, information, stress, mirna, offspring, nat, neurosci, genome, university, institute, research, analyses, samples, total,

Topics {✒️}

nature portfolio permissions reprints research “neural plasticity zürich informatics services privacy policy advertising teperino nature social media nature 461 nature 441 nature author correspondence springerlink instant access naïve c57bl/6j females endangered black-footed ferret early life stress gene expression sperm-borne mitochondrial rnas long-term memory acute restraint stress permissions similar mirna expression diet-induced combined control libraries julien prados privacy long rnas c57bl/6j males repeated sampling facilitates c57bl/6j females swiss federal institute present address competing financial interests communications article laboratory animal science behaviour molecular neuroscience explore content subscription content sequencing libraries combined libraries traumatic stress maternal stress sperm rna preparation european economic area institutional subscriptions read caius college fellowship plan-les-ouates dsdna hs assay q-bit assay mice katharina gapp

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice
         description:In this study, the authors show that the heritable behavioral and metabolic changes that are observed in rodents exposed to early life stress are mediated by changes in miRNA levels in the sperm of affected males. Injection of isolated RNA from the sperm of stressed males into donor fertilized oocytes is able to induce these phenotypic changes in the resulting offspring. Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
         datePublished:2014-04-13T00:00:00Z
         dateModified:2014-04-13T00:00:00Z
         pageStart:667
         pageEnd:669
         sameAs:https://doi.org/10.1038/nn.3695
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            Molecular neuroscience
            Biomedicine
            general
            Neurosciences
            Behavioral Sciences
            Biological Techniques
            Neurobiology
            Animal Genetics and Genomics
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      headline:Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice
      description:In this study, the authors show that the heritable behavioral and metabolic changes that are observed in rodents exposed to early life stress are mediated by changes in miRNA levels in the sperm of affected males. Injection of isolated RNA from the sperm of stressed males into donor fertilized oocytes is able to induce these phenotypic changes in the resulting offspring. Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
      datePublished:2014-04-13T00:00:00Z
      dateModified:2014-04-13T00:00:00Z
      pageStart:667
      pageEnd:669
      sameAs:https://doi.org/10.1038/nn.3695
      keywords:
         Epigenetics and behaviour
         Molecular neuroscience
         Biomedicine
         general
         Neurosciences
         Behavioral Sciences
         Biological Techniques
         Neurobiology
         Animal Genetics and Genomics
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      isPartOf:
         name:Nature Neuroscience
         issn:
            1546-1726
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         name:Nature Publishing Group US
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      author:
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            affiliation:
                  name:Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology
                  address:
                     name:Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland
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                     name:Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland
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                     name:Institute of Laboratory Animal Science, University of Zürich, Zürich, Switzerland
                     type:PostalAddress
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                     name:FASTERIS SA, Plan-les-Ouates, Switzerland
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                     type:PostalAddress
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                  name:Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology
                  address:
                     name:Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland
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               type:PostalAddress
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      affiliation:
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            address:
               name:Gurdon Institute, Cambridge, UK
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      name:Isabelle M Mansuy
      affiliation:
            name:Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology
            address:
               name:Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland
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      name:Gurdon Institute, Cambridge, UK
      name:Brain Research Institute, Neuroscience Center Zürich, University of Zürich and Swiss Federal Institute of Technology, Zürich, Switzerland
      name:Institute of Laboratory Animal Science, University of Zürich, Zürich, Switzerland
      name:FASTERIS SA, Plan-les-Ouates, Switzerland
      name:Present address: Neuroscience Center, University Geneva, Geneva, Switzerland.,
      name:FASTERIS SA, Plan-les-Ouates, Switzerland
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Social Networks {👍}(1)

External Links {🔗}(213)

Analytics and Tracking {📊}

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Mail Servers:

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CDN Services {📦}

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