
DOI . ORG {
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Title[redir]:
Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice | Nature Neuroscience
Description:
In this study, the authors show that the heritable behavioral and metabolic changes that are observed in rodents exposed to early life stress are mediated by changes in miRNA levels in the sperm of affected males. Injection of isolated RNA from the sperm of stressed males into donor fertilized oocytes is able to induce these phenotypic changes in the resulting offspring. Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
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msus, article, control, google, scholar, cas, reads, nature, supplementary, rnas, mice, sperm, figure, data, adult, animals, mirp, access, rna, biol, sem, content, expression, males, zürich, libraries, cookies, neuroscience, mansuy, mouse, metabolic, sequencing, size, mapping, mirnas, msusrnainj, privacy, information, stress, mirna, offspring, nat, neurosci, genome, university, institute, research, analyses, samples, total,
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nature portfolio permissions reprints research “neural plasticity zürich informatics services privacy policy advertising teperino nature social media nature 461 nature 441 nature author correspondence springerlink instant access naïve c57bl/6j females endangered black-footed ferret early life stress gene expression sperm-borne mitochondrial rnas long-term memory acute restraint stress permissions similar mirna expression diet-induced combined control libraries julien prados privacy long rnas c57bl/6j males repeated sampling facilitates c57bl/6j females swiss federal institute present address competing financial interests communications article laboratory animal science behaviour molecular neuroscience explore content subscription content sequencing libraries combined libraries traumatic stress maternal stress sperm rna preparation european economic area institutional subscriptions read caius college fellowship plan-les-ouates dsdna hs assay q-bit assay mice katharina gapp
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headline:Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice
description:In this study, the authors show that the heritable behavioral and metabolic changes that are observed in rodents exposed to early life stress are mediated by changes in miRNA levels in the sperm of affected males. Injection of isolated RNA from the sperm of stressed males into donor fertilized oocytes is able to induce these phenotypic changes in the resulting offspring. Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
datePublished:2014-04-13T00:00:00Z
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description:In this study, the authors show that the heritable behavioral and metabolic changes that are observed in rodents exposed to early life stress are mediated by changes in miRNA levels in the sperm of affected males. Injection of isolated RNA from the sperm of stressed males into donor fertilized oocytes is able to induce these phenotypic changes in the resulting offspring. Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.
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