We are analyzing https://link.springer.com/article/10.1007/s11481-012-9350-7.

Title:
A Role for WNT/β-Catenin Signaling in the Neural Mechanisms of Behavior | Journal of Neuroimmune Pharmacology
Description:
Wnt signaling pathways play a role in a variety of cellular processes including development, cell proliferation, cell fate, and motility. The Wnt/β-catenin pathway is among the most studied of the Wnt pathways and is highly conserved throughout evolution. Recent in vitro and slice physiology experiments have shown that this pathway also functions in synaptic transmission and activity-dependent synaptic plasticity. Since it has now been shown that many components of this signaling pathway are found in the adult brain, Wnt/β-catenin signaling may be important for maintaining and protecting neural connections throughout the lifespan. Here we summarize the role of Wnt/β-catenin signaling in the postnatal brain and discuss recent studies suggesting that deregulated Wnt signaling can result in altered behavior and cognitive disorders.
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Keywords {🔍}

pubmed, google, scholar, cas, central, signaling, wnt, cell, betacatenin, biol, kinase, synaptic, brain, synthase, glycogen, neurosci, role, article, signalling, chem, wntβcatenin, ressler, development, pathway, mouse, inestrosa, neural, adult, hippocampal, psychiatry, res, research, activation, lithium, chen, regulates, hippocampus, disease, mice, memory, privacy, cookies, content, journal, behavior, maguschak, pathways, access, related, learning,

Topics {✒️}

akt/gsk-3beta/beta-catenin signalling wnt-5a/jnk signaling promotes wnt-dishevelled-gsk3beta signaling cascade activity-dependent synaptic plasticity acetylcholinesterase-amyloid-beta-peptide interaction disrupting cadherin-beta-catenin interactions dentate gyrus-specific knockdown glycogen synthase kinase-3beta glycogen-synthase-kinase-3beta month download article/chapter wnt/beta-catenin signaling pathway wnt/β-catenin signalling beta-catenin nuclear signalling regulates beta-catenin expression gsk3beta/beta-catenin signaling depolarization drives beta-catenin wnt/β-catenin signaling wnt/beta -catenin signaling amygdala-dependent learning wnt/β-catenin pathway de ferrari gv e-cadherin/catenin association lithium blocks stress-induced appswe/psen1deltae9 mouse model glycogen synthase kinase-3 beta-catenin signalling learning-dependent activation protein kinase wnt-mediated activation yerkes research center beta-catenin activation disc1-binding proteins express gsk-3beta adult-born neurons privacy choices/manage cookies beta-catenin overexpression beta-catenin independent selective gsk-3 inhibitor nmda-based therapeutics wnt-7a signaling behavioral impairments induced wnt-7a modulates hippocampal cell fate funding support related beta-catenin structure microtubule growth directionality financial disclosure statement beta-amyloid fibrils localize synaptic vesicles deregulated wnt signaling

Questions {❓}

Li X, Jope RS (2010) Is glycogen synthase kinase-3 a central modulator in mood regulation?

Schema {🗺️}

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