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DOI . ORG {}

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  4. Monthly Traffic Estimate
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  6. Keywords
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We began analyzing https://www.nature.com/articles/ni.2986, but it redirected us to https://www.nature.com/articles/ni.2986. The analysis below is for the second page.

Title[redir]:
Diversification of TAM receptor tyrosine kinase function | Nature Immunology
Description:
The clearance of apoptotic cells requires recognition by members of the TAM receptor tyrosine kinase family. Lemke and colleagues show that the TAM receptors Mer and Axl have distinct functions in tolerance induction and proinflammatory responses, respectively. The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer had distinct roles as phagocytic receptors in these two settings, in which they exhibited divergent expression, regulation and activity. Mer acted as a tolerogenic receptor in resting macrophages and during immunosuppression. In contrast, Axl was an inflammatory response receptor whose expression was induced by proinflammatory stimuli. Axl and Mer differed in their ligand specificities, ligand-receptor complex formation in tissues, and receptor shedding upon activation. These differences notwithstanding, phagocytosis by either protein was strictly dependent on receptor activation triggered by bridging of TAM receptor–ligand complexes to the

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

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Traffic Estimate {📈}

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

pubmed, google, scholar, cas, axl, receptor, cells, mer, central, nature, cell, apoptotic, tam, tyrosine, immunol, experiments, data, kinase, lemke, macrophages, supplementary, independent, article, phagocytosis, access, representative, clearance, receptors, dex, activation, open, nat, immune, figure, content, expression, response, protein, signaling, source, cookies, regulation, mertk, gas, mice, arrowheads, fig, privacy, information, dendritic,

Topics {✒️}

nature portfolio permissions reprints inflammation research privacy policy cd11c+cd11b-mhcii-f4/80lo advertising flow-cytometry-based phagocytosis assay social media author information authors nature 411 nature 398 nature 450 nature ligand-receptor complex formation monoclonal anti-receptor antibodies growth-arrest-specific protein 6 middle lipopolysaccharide-induced endotoxic shock tam receptor–ligand complexes tam receptor-ligand interaction enhanced antibody-forming cell elmo/dock180/rac module ligand-dependent kinase activity author correspondence mertk drives efferocytosis open arrowheads receptor tyrosine kinase tam receptor signaling springerlink instant access inhibits tnf-alpha production receptor tyrosine kinases axl/mertk/tyro3 receptors permissions clathrin-independent pathway collagen-induced arthritis tingible body macrophages blocks tumor spread tyro-3 family receptors nuclear receptor lxr glucocorticoid-induced genes met kinase superfamily anti-inflammatory functions mertk differentially contribute cell-derived protein privacy metastatic breast cancer p38 signaling pathways article zagórska innate immune response inflammatory response receptor

Schema {🗺️}

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         headline:Diversification of TAM receptor tyrosine kinase function
         description:The clearance of apoptotic cells requires recognition by members of the TAM receptor tyrosine kinase family. Lemke and colleagues show that the TAM receptors Mer and Axl have distinct functions in tolerance induction and proinflammatory responses, respectively. The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer had distinct roles as phagocytic receptors in these two settings, in which they exhibited divergent expression, regulation and activity. Mer acted as a tolerogenic receptor in resting macrophages and during immunosuppression. In contrast, Axl was an inflammatory response receptor whose expression was induced by proinflammatory stimuli. Axl and Mer differed in their ligand specificities, ligand-receptor complex formation in tissues, and receptor shedding upon activation. These differences notwithstanding, phagocytosis by either protein was strictly dependent on receptor activation triggered by bridging of TAM receptor–ligand complexes to the 'eat-me' signal phosphatidylserine on the surface of apoptotic cells.
         datePublished:2014-09-07T00:00:00Z
         dateModified:2014-09-07T00:00:00Z
         pageStart:920
         pageEnd:928
         sameAs:https://doi.org/10.1038/ni.2986
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            Autoimmunity
            Cell death and immune response
            Chronic inflammation
            Phagocytes
            Biomedicine
            general
            Immunology
            Infectious Diseases
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      headline:Diversification of TAM receptor tyrosine kinase function
      description:The clearance of apoptotic cells requires recognition by members of the TAM receptor tyrosine kinase family. Lemke and colleagues show that the TAM receptors Mer and Axl have distinct functions in tolerance induction and proinflammatory responses, respectively. The clearance of apoptotic cells is critical for both tissue homeostasis and the resolution of inflammation. We found that the TAM receptor tyrosine kinases Axl and Mer had distinct roles as phagocytic receptors in these two settings, in which they exhibited divergent expression, regulation and activity. Mer acted as a tolerogenic receptor in resting macrophages and during immunosuppression. In contrast, Axl was an inflammatory response receptor whose expression was induced by proinflammatory stimuli. Axl and Mer differed in their ligand specificities, ligand-receptor complex formation in tissues, and receptor shedding upon activation. These differences notwithstanding, phagocytosis by either protein was strictly dependent on receptor activation triggered by bridging of TAM receptor–ligand complexes to the 'eat-me' signal phosphatidylserine on the surface of apoptotic cells.
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         Autoimmunity
         Cell death and immune response
         Chronic inflammation
         Phagocytes
         Biomedicine
         general
         Immunology
         Infectious Diseases
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               type:PostalAddress
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Social Networks {👍}(1)

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Analytics and Tracking {📊}

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