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Title[redir]:
T cell-derived Protein S engages TAM signaling in Dendritic Cells to control the magnitude of the immune response - PMC
Description:
Dendritic cell (DC) activation is essential for the induction of immune defense against pathogens, yet needs to be tightly controlled to avoid chronic inflammation and exaggerated immune responses. Here, we identify a mechanism of immune homeostasis ...
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Keywords {🔍}
cells, pros, mice, doi, figure, activated, cell, activation, expression, dcs, immune, otii, pubmed, google, scholar, protein, human, bmdcs, cellderived, tam, control, usa, function, levels, results, representative, pmc, negative, cocultured, response, colitis, isolated, data, shown, prosfloxflox, cdc, free, antigen, vitro, presence, cdcre, disease, patients, μgml, cdcd, loss, pdf, signaling, article, prosfloxfloxcdcre,
Topics {✒️}
tnp-klh-immunized pros1flox/flox cd4-cre− pros1flox/flox cd4-cre− ot-ii pros1flox/flox cd4-cre+ ot-ii pros1flox/flox cd4-cre−ot-ii pros1flox/floxcd4-cre− ot-ii mice pros1flox/floxcd4-cre+ ot-ii pros1flox/floxcd4-cre+ mice showed pros1flox/flox cd4-cre+ mice [pubmed] [google scholar] pros1flox/floxcd4-cre+ mice immunized cd4+cd25− ot-ii ctrl pros1flox/flox cd4-cre+ pros1flox/flox cd4-cre− control cd4+cd25−cd45rbhigh recipients cell-derived pros1-mediated regulation pros1flox/floxcd4-cre+ mice pros1flox/floxcd4-cre+mice gershon-trudeau postdoctoral fellowship crossed pros1flox/floxcd4-cre+ t-independent antigen tnp-ficoll pros1flox/floxlck-cre+ mice phospho-nf-κb p65 pmc beta search ot-ii transgenic cd4+ pros1-expressing ot-ii ot-ii transgenic mice ctrl ot-ii tc pros1 ko ot-ii cd4+cd25−cd45rbhigh cells increased p65nf-κb phosphorylation pros1flox/floxcd4-cre− endogenous anti-inflammatory protein cell-derived pros1 depends vitamin k-dependent protein tnp-ficoll-immunized mice ova/5 ng lps/emulsified tam receptor-ligand interaction protein s-deficient mice human monocyte-derived dcs monocyte-derived dcs express specific pathogen free anti-inflammatory pathway serum free medium cultured cd4+cd25−cells obtained garcia de frutos retinal pigment epithelium ot-ii mice pre-activated cd4+cd25− receptor tyrosine kinases pros1 acts locally
Questions {❓}
- , Jr Approaching the asymptote?
- Is the duality of Pros1 function relevant in physiological or pathological settings?
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