We are analyzing https://link.springer.com/article/10.1007/bf01570464.

Title:
Do histocompatibility antigens recognize themselves? | Immunogenetics
Description:
In the Simonsen spleen weight assay, theH-2K ba mutant does not respond against theH-2K bd mutant orH-2K bd /H-2K b hybrid, while the parentalH-2K b haplotype does respond. TheH-2K ba /H-2K b hybrid reacts strongly to bothH-2K bd andH-2K bd /H-2K b , indicating that the donor genotype could influence the reactivity against the same antigenic difference. The response of theH-2 ba mutant against a number of unrelated H-2 antigens does not differ from that of the parental haplotype. TheH-2K bd mutant reacts againstH-2K b andH-2K ba , and theH-2K b parent reacts against both theH-2K ba andH-2K bd mutants. The specific defect of reactivity in theH-2K ba mutant is effectively complemented by crossing with a number of unrelatedH-2 haplotypes. TheH-2 ka andH-2 fa mutants complement poorly compared to corresponding parental strains CBA and A.CA, while the B10.M (H-2 f ) strain does not complement at all (which is probably attributable to an undetectedH-2 mutation in the last strain). The data strongly suggest that the product of theH-2K locus-which is known to function as a transplantation antigen, lymphocyte activating determinant, and serologically defined antigen-also influences the immune response capacity against a mutant histocompatibility determinant.
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Topics {✒️}

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Questions {❓}

Do histocompatibility antigens recognize themselves?
Do histocompatibility antigens recognize themselves?

Schema {🗺️}

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         description:In the Simonsen spleen weight assay, theH-2K ba mutant does not respond against theH-2K bd mutant orH-2K bd /H-2K b hybrid, while the parentalH-2K b haplotype does respond. TheH-2K ba /H-2K b hybrid reacts strongly to bothH-2K bd andH-2K bd /H-2K b , indicating that the donor genotype could influence the reactivity against the same antigenic difference. The response of theH-2 ba mutant against a number of unrelated H-2 antigens does not differ from that of the parental haplotype. TheH-2K bd mutant reacts againstH-2K b andH-2K ba , and theH-2K b parent reacts against both theH-2K ba andH-2K bd mutants. The specific defect of reactivity in theH-2K ba mutant is effectively complemented by crossing with a number of unrelatedH-2 haplotypes. TheH-2 ka andH-2 fa mutants complement poorly compared to corresponding parental strains CBA and A.CA, while the B10.M (H-2 f ) strain does not complement at all (which is probably attributable to an undetectedH-2 mutation in the last strain). The data strongly suggest that the product of theH-2K locus-which is known to function as a transplantation antigen, lymphocyte activating determinant, and serologically defined antigen-also influences the immune response capacity against a mutant histocompatibility determinant.
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      description:In the Simonsen spleen weight assay, theH-2K ba mutant does not respond against theH-2K bd mutant orH-2K bd /H-2K b hybrid, while the parentalH-2K b haplotype does respond. TheH-2K ba /H-2K b hybrid reacts strongly to bothH-2K bd andH-2K bd /H-2K b , indicating that the donor genotype could influence the reactivity against the same antigenic difference. The response of theH-2 ba mutant against a number of unrelated H-2 antigens does not differ from that of the parental haplotype. TheH-2K bd mutant reacts againstH-2K b andH-2K ba , and theH-2K b parent reacts against both theH-2K ba andH-2K bd mutants. The specific defect of reactivity in theH-2K ba mutant is effectively complemented by crossing with a number of unrelatedH-2 haplotypes. TheH-2 ka andH-2 fa mutants complement poorly compared to corresponding parental strains CBA and A.CA, while the B10.M (H-2 f ) strain does not complement at all (which is probably attributable to an undetectedH-2 mutation in the last strain). The data strongly suggest that the product of theH-2K locus-which is known to function as a transplantation antigen, lymphocyte activating determinant, and serologically defined antigen-also influences the immune response capacity against a mutant histocompatibility determinant.
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