NATURE . COM {}

Matching Content Categories {📚}

• Science
• Education
• Social Networks

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,555,829 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$536,300 per month
Our estimates place Nature.com's monthly online earnings from display ads at $357,511 to $983,155.

Keywords {🔍}

article, nature, google, scholar, cas, ads, cells, access, mhc, content, class, cookies, selection, molecules, kisielow, teh, tcr, privacy, boehmer, immunology, data, positive, antigenspecific, thymus, thymic, bevan, immun, proc, research, advertising, information, subscribe, restricting, pawel, hung, sia, blüthmann, binding, institution, learn, buy, open, cell, natn, acad, sci, usa, exp, med, immunogenetics,

Topics {✒️}

nature portfolio permissions reprints privacy policy t-cell development advertising social media subscribe nature hung sia teh nature 320 nature 325 nature 328 nature 335 nature 333 nature 269 nature 292 nature 332 nature personal data cell central tolerance springerlink instant access data protection permissions von boehmer thymic mhc molecules privacy restricting mhc molecules article kisielow explore content subscription content cds molecules expressed mhc-restricted cd4−8+ european economic area major histocompatibility complex αβ tcr expressed provide direct evidence issue learn institutional subscriptions read hoffmann–la roche accepting optional cookies tcr transgenic mice cd4/cd8 phenotype immature cd4+8+ thymocytes cd4 improve detection journals search log cells article 03 manage preferences immune system learn class ii content article purchase

Questions {❓}

• How does the immune system learn to distinguish between good and evil?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
         description:Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II molecules encoded by the major histocompatibility complex (MHC) by virtue of the heterodimeric αβ T-cell receptor (TCR)1,2. CD4 and CDS molecules expressed on the surface of T cells bind to nonpolymorphic portions of class II and class I MHC molecules and assist the TCR in binding and possibly in signalling3,4. The analysis of T-cell development in TCR transgenic mice has shown that the CD4/CD8 phenotype of T cells is determined by the interaction of the αβ TCR expressed on immature CD4+8+ thymocytes with polymorphic domains of thymic MHC molecules in the absence of nominal antigen5. Here we provide direct evidence that positive selection of antigen-specific, class I MHC-restricted CD4−8+ T cells in the thymus requires the specific interaction of the αβ TCR with the restricting class I MHC molecule.
         datePublished:
         dateModified:
         pageStart:730
         pageEnd:733
         sameAs:https://doi.org/10.1038/335730a0
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:335
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Pawel Kisielow
               affiliation:
                     name:Basel Institute for Immunology
                     address:
                        name:Basel Institute for Immunology, Basel, Switzerland
                        type:PostalAddress
                     type:Organization
                     name:Polish Academy of Sciences
                     address:
                        name:The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hung Sia Teh
               affiliation:
                     name:Basel Institute for Immunology
                     address:
                        name:Basel Institute for Immunology, Basel, Switzerland
                        type:PostalAddress
                     type:Organization
                     name:University of British Columbia
                     address:
                        name:Department of Microbiology, University of British Columbia, Vancouver, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Horst Blüthmann
               affiliation:
                     name:F. Hoffmann–La Roche & Co. Ltd
                     address:
                        name:Central Research Units, F. Hoffmann–La Roche & Co. Ltd, Basel, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Harald von Boehmer
               affiliation:
                     name:Basel Institute for Immunology
                     address:
                        name:Basel Institute for Immunology, Basel, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
      description:Thymus-derived lymphocytes (T cells) recognize antigen in the context of class I or class II molecules encoded by the major histocompatibility complex (MHC) by virtue of the heterodimeric αβ T-cell receptor (TCR)1,2. CD4 and CDS molecules expressed on the surface of T cells bind to nonpolymorphic portions of class II and class I MHC molecules and assist the TCR in binding and possibly in signalling3,4. The analysis of T-cell development in TCR transgenic mice has shown that the CD4/CD8 phenotype of T cells is determined by the interaction of the αβ TCR expressed on immature CD4+8+ thymocytes with polymorphic domains of thymic MHC molecules in the absence of nominal antigen5. Here we provide direct evidence that positive selection of antigen-specific, class I MHC-restricted CD4−8+ T cells in the thymus requires the specific interaction of the αβ TCR with the restricting class I MHC molecule.
      datePublished:
      dateModified:
      pageStart:730
      pageEnd:733
      sameAs:https://doi.org/10.1038/335730a0
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:335
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Pawel Kisielow
            affiliation:
                  name:Basel Institute for Immunology
                  address:
                     name:Basel Institute for Immunology, Basel, Switzerland
                     type:PostalAddress
                  type:Organization
                  name:Polish Academy of Sciences
                  address:
                     name:The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hung Sia Teh
            affiliation:
                  name:Basel Institute for Immunology
                  address:
                     name:Basel Institute for Immunology, Basel, Switzerland
                     type:PostalAddress
                  type:Organization
                  name:University of British Columbia
                  address:
                     name:Department of Microbiology, University of British Columbia, Vancouver, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Horst Blüthmann
            affiliation:
                  name:F. Hoffmann–La Roche & Co. Ltd
                  address:
                     name:Central Research Units, F. Hoffmann–La Roche & Co. Ltd, Basel, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Harald von Boehmer
            affiliation:
                  name:Basel Institute for Immunology
                  address:
                     name:Basel Institute for Immunology, Basel, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:335
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Basel Institute for Immunology
      address:
         name:Basel Institute for Immunology, Basel, Switzerland
         type:PostalAddress
      name:Polish Academy of Sciences
      address:
         name:The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
         type:PostalAddress
      name:Basel Institute for Immunology
      address:
         name:Basel Institute for Immunology, Basel, Switzerland
         type:PostalAddress
      name:University of British Columbia
      address:
         name:Department of Microbiology, University of British Columbia, Vancouver, Canada
         type:PostalAddress
      name:F. Hoffmann–La Roche & Co. Ltd
      address:
         name:Central Research Units, F. Hoffmann–La Roche & Co. Ltd, Basel, Switzerland
         type:PostalAddress
      name:Basel Institute for Immunology
      address:
         name:Basel Institute for Immunology, Basel, Switzerland
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Pawel Kisielow
      affiliation:
            name:Basel Institute for Immunology
            address:
               name:Basel Institute for Immunology, Basel, Switzerland
               type:PostalAddress
            type:Organization
            name:Polish Academy of Sciences
            address:
               name:The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
               type:PostalAddress
            type:Organization
      name:Hung Sia Teh
      affiliation:
            name:Basel Institute for Immunology
            address:
               name:Basel Institute for Immunology, Basel, Switzerland
               type:PostalAddress
            type:Organization
            name:University of British Columbia
            address:
               name:Department of Microbiology, University of British Columbia, Vancouver, Canada
               type:PostalAddress
            type:Organization
      name:Horst Blüthmann
      affiliation:
            name:F. Hoffmann–La Roche & Co. Ltd
            address:
               name:Central Research Units, F. Hoffmann–La Roche & Co. Ltd, Basel, Switzerland
               type:PostalAddress
            type:Organization
      name:Harald von Boehmer
      affiliation:
            name:Basel Institute for Immunology
            address:
               name:Basel Institute for Immunology, Basel, Switzerland
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Basel Institute for Immunology, Basel, Switzerland
      name:The Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
      name:Basel Institute for Immunology, Basel, Switzerland
      name:Department of Microbiology, University of British Columbia, Vancouver, Canada
      name:Central Research Units, F. Hoffmann–La Roche & Co. Ltd, Basel, Switzerland
      name:Basel Institute for Immunology, Basel, Switzerland
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(74)

• What are the total earnings of https://link.springer.com/article/10.1038/335730a0?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle?
• How much money does https://doi.org/10.1038%2F320232a0 generate?
• How much money does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1986Natur.320..232D make?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F320232a0&volume=320&pages=232-238&publication_year=1986&author=Dembic%2CZ?
• What's the income generated by https://doi.org/10.1038%2F325125a0 each month?
• What's the revenue for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1987Natur.325..125S?
• How much income is http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F325125a0&volume=325&pages=125-130&publication_year=1987&author=Saito%2CT earning monthly?
• Get to know what's the income of https://doi.org/10.1016%2F0092-8674%2887%2990027-4
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2887%2990027-4&volume=50&pages=545-554&publication_year=1987&author=Gabert%2CJ earn?
• Discover the revenue of https://doi.org/10.1038%2F328626a0
• Get to know what's the income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1987Natur.328..626G
• What's the profit of http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F328626a0&volume=328&pages=626-629&publication_year=1987&author=Gay%2CD?
• What's the monthly money flow for https://doi.org/10.1038%2F335229a0?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1988Natur.335..229T rake in every month?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F335229a0&volume=335&pages=229-233&publication_year=1988&author=Teh%2CHS rake in every month?
• How much profit does https://doi.org/10.1038%2F333742a0 generate?
• How much profit is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1988Natur.333..742K making per month?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F333742a0&volume=333&pages=742-746&publication_year=1988&author=Kisielow%2CP gross monthly?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2580901 rake in every month?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=J.%20Immun.&volume=134&pages=3994-4000&publication_year=1985&author=Staerz%2CU&author=Rammensee%2CH&author=Benedetto%2CJ&author=Bevan%2CM rake in every month?
• What's the revenue for https://doi.org/10.1073%2Fpnas.74.5.2094?
• Monthly income for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1977PNAS...74.2094B
• What's the monthly income of http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.74.5.2094&volume=74&pages=2094-2098&publication_year=1977&author=Bevan%2CMJ?
• What are the earnings of https://doi.org/10.1073%2Fpnas.74.3.1229?
• Check the income stats for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1977PNAS...74.1229L
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.74.3.1229&volume=74&pages=1229-1233&publication_year=1977&author=Lemmonier%2CF&author=Burakoff%2CSJ&author=Germain%2CRN&author=Benaceraff%2CB
• What's the profit of https://doi.org/10.1111%2Fj.1600-065X.1981.tb00438.x?
• What's the income of http://scholar.google.com/scholar_lookup?&title=&journal=Immun.%20Rev.&doi=10.1111%2Fj.1600-065X.1981.tb00438.x&volume=54&pages=187-223&publication_year=1981&author=Sredni%2CB&author=Schwartz%2CRH?
• What is the earnings of https://doi.org/10.1002%2Feji.1830090804?
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=&journal=Eur.%20J.%20Immun.&doi=10.1002%2Feji.1830090804&volume=9&pages=592-597&publication_year=1979&author=von%20Boehmer%2CH?
• Income figures for https://doi.org/10.1038%2F269417a0
• Learn how profitable http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1977Natur.269..417B is on a monthly basis
• Get to know http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F269417a0&volume=269&pages=417-419&publication_year=1977&author=Bevan%2CMJ's earnings
• How profitable is https://doi.org/10.1084%2Fjem.147.3.882?
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=&journal=J.%20exp.%20Med.&doi=10.1084%2Fjem.147.3.882&volume=147&pages=882-896&publication_year=1987&author=Zinkernagel%2CRM?
• Monthly income for https://doi.org/10.1073%2Fpnas.75.5.2439
• How much revenue does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1978PNAS...75.2439V generate?
• How much profit is http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.75.5.2439&volume=75&pages=2434-2442&publication_year=1978&author=von%20Boehmer%2CH&author=Haas%2CW&author=Jerne%2CNK making per month?
• What's the financial outcome of https://doi.org/10.1084%2Fjem.148.6.1510?
• What's the income of http://scholar.google.com/scholar_lookup?&title=&journal=J.%20exp.%20Med.&doi=10.1084%2Fjem.148.6.1510&volume=148&pages=1510-1522&publication_year=1978&author=Kappler%2CJ&author=Marrack%2CPJ?
• What's the revenue for http://scholar.google.com/scholar_lookup?&title=Immunology%3A%20the%20Science%20of%20Self-Non-Self%20Discrimination&publication_year=1982&author=Klein%2CJ?
• How much money does https://doi.org/10.1038%2F292497a0 generate?
• How much money does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1981Natur.292..497M generate?
• http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F292497a0&volume=292&pages=497-499&publication_year=1981&author=Matzinger%2CP income
• What's the monthly money flow for https://link.springer.com/doi/10.1007/BF01570464?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Immunogenetics&doi=10.1007%2FBF01570464&volume=5&pages=65-74&publication_year=1977&author=Egorov%2CIK&author=Mnatsakanyan%2C&author=Pospelov%2CLE generate monthly?
• What is the earnings of http://scholar.google.com/scholar_lookup?&title=&journal=Trans.%20Proc.&volume=5&pages=377-381&publication_year=1973&author=Meo%2CT&author=Vives%2CJ&author=Miggiano%2CV&author=Shreffler%2CD?
• Learn how profitable https://doi.org/10.1084%2Fjem.155.1.111 is on a monthly basis
• How much revenue does http://scholar.google.com/scholar_lookup?&title=&journal=J.%20exp.%20Med.&doi=10.1084%2Fjem.155.1.111&volume=155&pages=111-125&publication_year=1982&author=H%C3%BCnig%2CT&author=Bevan%2CMJ produce monthly?
• How much does https://doi.org/10.1038%2F332840a0 gross monthly?
• What's the financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1988Natur.332..840M?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F332840a0&volume=332&pages=840-843&publication_year=1988&author=Marrack%2CP&author=Kappler%2CJ generate?
• Explore the financials of https://doi.org/10.1002%2Feji.1830121016
• Income figures for http://scholar.google.com/scholar_lookup?&title=&journal=Eur.%20J.%20Immun.&doi=10.1002%2Feji.1830121016&volume=12&pages=887-892&publication_year=1982&author=Teh%2CHS&author=Bennink%2CJ&author=von%20Boehmer%2CH
• What are the total earnings of https://citation-needed.springer.com/v2/references/10.1038/335730a0?format=refman&flavour=references?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Pawel%20Kisielow generate monthly?
• How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Pawel%20Kisielow%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en produce monthly?
• What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hung%20Sia%20Teh?
• Profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hung%20Sia%20Teh%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Horst%20Bl%C3%BCthmann rake in every month?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Horst%20Bl%C3%BCthmann%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earn?
• Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Harald%20von%20Boehmer
• What's the financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Harald%20von%20Boehmer%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• Discover the revenue of https://s100.copyright.com/AppDispatchServlet?title=Positive%20selection%20of%20antigen-specific%20T%20cells%20in%20thymus%20by%20restricting%20MHC%20molecules&author=Pawel%20Kisielow%20et%20al&contentID=10.1038%2F335730a0©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=1988-10-20&publisherName=SpringerNature&orderBeanReset=true
• https://citation-needed.springer.com/v2/references/10.1038/335730a0?format=refman&flavour=citation's total income per month
• What's the profit of https://doi.org/10.1038/s41577-023-00911-8?
• How much does https://doi.org/10.1007/s00281-021-00842-3 pull in?
• How much income does https://doi.org/10.1007/s00251-019-01127-8 have?
• How much revenue does https://doi.org/10.1007/s00251-018-1081-3 produce monthly?
• How much money does https://doi.org/10.1038/icb.2014.122 make?
• Get to know what's the income of https://www.protocols.io/
• How much revenue does https://www.natureindex.com/ generate?
• What's the income generated by http://www.naturechina.com each month?
• How much revenue does https://www.natureasia.com/ja-jp produce monthly?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref