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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
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  14. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s12016-021-08898-7, but it redirected us to https://link.springer.com/article/10.1007/s12016-021-08898-7. The analysis below is for the second page.

Title[redir]:
The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies | Clinical Reviews in Allergy & Immunology
Description:
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by diverse serological autoantibodies. Anti-dsDNA antibodies are involved in multiple organ damage, especially the kidney, skin, and central nervous system. Anti-dsDNA antibodies play a pivotal role in SLE, and researchers have developed therapeutic strategies targeting these antibodies. Approaches to reduce anti-dsDNA antibodies via B cell targeted biologics against B cell surface antigens, B cell survival factors, or Bruton’s tyrosine kinase have effectively eliminated B cells. However, their non-specific depletion hampers normal immune system functioning and limits the therapeutic benefits. Thus, scientists have attempted anti-dsDNA antibodies or lupus-specific strategies, such as the immature dendritic cell vaccine and immunoadsorption. Recently, synthetic mimic peptides (hCDR1, pCONs, DWEYS, FISLE-412, and ALW) that directly block anti-dsDNA autoantibodies have attracted attention, which could ameliorate lupus, decrease the serological autoantibody titer, reduce the deposition of renal autoantibodies, and improve pathological performance. These potent small peptide molecules are well tolerated, non-toxic, and non-immunogenic, which have demonstrated a benign safety profile and are expected to be hopeful candidates for SLE management. In this review, we clarify the role of anti-dsDNA antibodies in SLE, mainly focus on the current strategies targeting anti-dsDNA antibodies, and discuss their potential clinical value.

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 98,426,998 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We can't figure out the monetization strategy.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Doi.org has a revenue plan, but it's either invisible or we haven't found it.

Keywords {🔍}

lupus, article, google, scholar, sle, cas, antidsdna, cell, cells, antibodies, patients, erythematosus, systemic, nephritis, baff, autoantibodies, igg, treatment, study, peptide, rituximab, immunol, arthritis, disease, phase, antigens, immune, renal, antibody, effect, antidna, mice, clinical, human, efficacy, including, based, active, trial, safety, activity, therapy, apoptosis, protein, randomized, rheum, therapeutic, hcdr, iii, receptor,

Topics {✒️}

enable anti-dsdna/anti-nmdar antibodies n-methyl-d-aspartate receptor antibody-dependent cell-mediated cytotoxicity c-jun nh2-terminal kinase anti-dna antibody-targeting organs anti-apoptotic molecule bcl-xl antiphospholipid syndrome anti-dsdna/anti-nmdar antibodies specific antigen-including dsdna anti-dsdna antibody subclass present mhc-antigen complex neutralize anti-dsdna antibodies dna-collodion-charcoal membranes anti-dsdna igg capable augments anti-dsdna igg reduce anti-dsdna antibodies anti-dsdna antibodies immunosuppressive target anti-dsdna antibodies serum anti-dsdna antibodies targeting anti-dsdna antibodies murine anti-dna antibodies p21ras/map kinase pathway anti-dsdna antibodies play article download pdf decreasing anti-dsdna antibodies anti-suprabasin autoantibodies account decreasing autophagosome-lysosome fusion b-cell activating factor humanized anti-cd19 mab recognize bcr-mediated internalized mitogen-activated protein kinase anti-dsdna antibodies contribute attempted anti-dsdna antibodies expand cd4+cd25+ tregs murine anti-dna autoantibodies anti-dna igg contributes enhance endoplasmic-reticulum stress similar mimic-neutralizing activities therapeutic small-molecule mimics anti-dsdna antibodies bind short half-life compromises anti-dsdna antibody long-term disease control huixia wang conceived systemic lupus erythematosus tweak/fn14 signaling pathway antibody-mediated glomerulonephritis tyrosine-protein kinase expressed central nervous system tweak/fn14 activation participates

Questions {❓}

  • Govoni M, Hanly JG (2020) The management of neuropsychiatric lupus in the 21st century: still so many unmet needs?
  • Jackson SW, Davidson A (2019) BAFF inhibition in SLE-Is tolerance restored?
  • Stohl W (2012) Biologic differences between various inhibitors of the BLyS/BAFF pathway: should we expect differences between belimumab and other inhibitors in development?

Schema {🗺️}

WebPage:
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         headline:The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies
         description:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by diverse serological autoantibodies. Anti-dsDNA antibodies are involved in multiple organ damage, especially the kidney, skin, and central nervous system. Anti-dsDNA antibodies play a pivotal role in SLE, and researchers have developed therapeutic strategies targeting these antibodies. Approaches to reduce anti-dsDNA antibodies via B cell targeted biologics against B cell surface antigens, B cell survival factors, or Bruton’s tyrosine kinase have effectively eliminated B cells. However, their non-specific depletion hampers normal immune system functioning and limits the therapeutic benefits. Thus, scientists have attempted anti-dsDNA antibodies or lupus-specific strategies, such as the immature dendritic cell vaccine and immunoadsorption. Recently, synthetic mimic peptides (hCDR1, pCONs, DWEYS, FISLE-412, and ALW) that directly block anti-dsDNA autoantibodies have attracted attention, which could ameliorate lupus, decrease the serological autoantibody titer, reduce the deposition of renal autoantibodies, and improve pathological performance. These potent small peptide molecules are well tolerated, non-toxic, and non-immunogenic, which have demonstrated a benign safety profile and are expected to be hopeful candidates for SLE management. In this review, we clarify the role of anti-dsDNA antibodies in SLE, mainly focus on the current strategies targeting anti-dsDNA antibodies, and discuss their potential clinical value.
         datePublished:2021-09-20T00:00:00Z
         dateModified:2021-09-20T00:00:00Z
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            Internal Medicine
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      headline:The Therapeutic Strategies for SLE by Targeting Anti-dsDNA Antibodies
      description:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by diverse serological autoantibodies. Anti-dsDNA antibodies are involved in multiple organ damage, especially the kidney, skin, and central nervous system. Anti-dsDNA antibodies play a pivotal role in SLE, and researchers have developed therapeutic strategies targeting these antibodies. Approaches to reduce anti-dsDNA antibodies via B cell targeted biologics against B cell surface antigens, B cell survival factors, or Bruton’s tyrosine kinase have effectively eliminated B cells. However, their non-specific depletion hampers normal immune system functioning and limits the therapeutic benefits. Thus, scientists have attempted anti-dsDNA antibodies or lupus-specific strategies, such as the immature dendritic cell vaccine and immunoadsorption. Recently, synthetic mimic peptides (hCDR1, pCONs, DWEYS, FISLE-412, and ALW) that directly block anti-dsDNA autoantibodies have attracted attention, which could ameliorate lupus, decrease the serological autoantibody titer, reduce the deposition of renal autoantibodies, and improve pathological performance. These potent small peptide molecules are well tolerated, non-toxic, and non-immunogenic, which have demonstrated a benign safety profile and are expected to be hopeful candidates for SLE management. In this review, we clarify the role of anti-dsDNA antibodies in SLE, mainly focus on the current strategies targeting anti-dsDNA antibodies, and discuss their potential clinical value.
      datePublished:2021-09-20T00:00:00Z
      dateModified:2021-09-20T00:00:00Z
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         Anti-dsDNA antibody
         Systemic lupus erythematosus (SLE)
         Target therapy
         Therapeutic peptide
         B cell
         Allergology
         Immunology
         Internal Medicine
      image:
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      name:Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
      name:Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

External Links {🔗}(389)

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Emails and Hosting {✉️}

Mail Servers:

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CDN Services {📦}

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