We are analyzing https://link.springer.com/article/10.1186/s13075-019-2038-0.

Title:
ALW peptide ameliorates lupus nephritis in MRL/lpr mice | Arthritis Research & Therapy
Description:
Background Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus. Anti-double-stranded (ds) DNA immunoglobulin G (IgG) plays a pivotal role in the pathogenesis of LN. Currently, there are various therapies for patients with LN; however, most of them are associated with considerable side effects. We confirmed previously that ALW (ALWPPNLHAWVP), a 12-amino acid peptide, inhibited the binding of polyclonal anti-dsDNA antibodies to mesangial cells and isolated glomeruli in vitro. In this study, we further investigate whether the administration of ALW peptide decreases renal IgG deposition and relevant damage in MRL/lpr lupus-prone mice. Methods Forty female MRL/lpr mice were randomly divided into four groups. The mice were intravenously injected with D-form ALW peptide (ALW group), scrambled peptide (PLP group), and normal saline (NaCl group) or were not treated (blank group). The IgG deposition, the histopathologic changes, and the expressions of profibrotic factors were analyzed in the kidney of MRL/lpr mice. Results Compared with the other groups, glomerular deposition of IgG, IgG2a, IgG2b, and IgG3 was decreased in the ALW group. Moreover, ALW administration attenuated renal histopathologic changes in MRL/lpr mice, including mesangial proliferation and infiltration of inflammatory cells. Furthermore, the expressions of profibrotic cytokines, such as transforming growth factor-beta1 (TGF-β1) and platelet-derived growth factor B (PDGF-B), decreased in the serum and kidney tissue of ALW-treated mice. Conclusions Our study demonstrated that ALW peptide ameliorates the murine model of LN, possibly through inhibiting renal IgG deposition and relevant tissue inflammation and fibrosis.
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Keywords {🔍}

mice, peptide, alw, igg, article, renal, google, scholar, mrllpr, antidsdna, cells, lupus, alwtreated, glomerular, antibodies, cas, nephritis, kidney, decreased, deposition, group, groups, iggb, fig, igga, serum, additional, infiltration, tgfβ, tissue, file, study, figure, pdgfb, significant, levels, cell, staining, administration, plp, sections, murine, tubular, igm, ctgf, results, showed, immunol, dna, mesangial,

Topics {✒️}

autoantibody-induced end-organ damage mrl/lpr lupus-prone mice anti-dna antibodies-quintessential biomarkers anti-dna antibodies cross-react transforming growth factor-beta1 alw-treated mrl/lpr mice systemic lupus erythematosus systemic lupus erythematosus platelet-derived growth factor enzyme-linked immunosorbent assays female mrl/lpr mice polyclonal anti-dsdna antibodies detectable anti-dsdna antibodies anti-dsdna igg participates ameliorates lupus nephritis pl9-11 anti-dna antibodies end-stage renal disease article download pdf human anti-dsdna antibodies d-form alw peptide d-form dweys peptide nonspecific protein-protein interactions total anti-dsdna igg glyceraldehyde-3-phosphate dehydrogenase values dna-mimic peptide screened murine anti-dna antibodies secreting pro-inflammatory cytokines serum anti-dsdna antibodies alw-treated mice showed fundamental research funds mouse anti-dsdna igg2b alw peptide ameliorates anti-double-stranded 100 μg/ml alw peptide 3-μm-thick paraffin sections transmission electron microscopy alw-treated mice compared human lupus nephritis 12-amino acid peptide intravenous delivery murine anti-dsdna igg2a spontaneous lupus nephritis double-stranded dna targeting mouse tgf-β1 arthritis res ther electron dense deposits murine lupus nephritis constant region contributes lupus-prone mice 100 μg/ml plp peptide

Questions {❓}

The role of anti-DNA antibodies in the development of lupus nephritis: a complementary, or alternative, viewpoint?

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         description:Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus. Anti-double-stranded (ds) DNA immunoglobulin G (IgG) plays a pivotal role in the pathogenesis of LN. Currently, there are various therapies for patients with LN; however, most of them are associated with considerable side effects. We confirmed previously that ALW (ALWPPNLHAWVP), a 12-amino acid peptide, inhibited the binding of polyclonal anti-dsDNA antibodies to mesangial cells and isolated glomeruli in vitro. In this study, we further investigate whether the administration of ALW peptide decreases renal IgG deposition and relevant damage in MRL/lpr lupus-prone mice. Forty female MRL/lpr mice were randomly divided into four groups. The mice were intravenously injected with D-form ALW peptide (ALW group), scrambled peptide (PLP group), and normal saline (NaCl group) or were not treated (blank group). The IgG deposition, the histopathologic changes, and the expressions of profibrotic factors were analyzed in the kidney of MRL/lpr mice. Compared with the other groups, glomerular deposition of IgG, IgG2a, IgG2b, and IgG3 was decreased in the ALW group. Moreover, ALW administration attenuated renal histopathologic changes in MRL/lpr mice, including mesangial proliferation and infiltration of inflammatory cells. Furthermore, the expressions of profibrotic cytokines, such as transforming growth factor-beta1 (TGF-β1) and platelet-derived growth factor B (PDGF-B), decreased in the serum and kidney tissue of ALW-treated mice. Our study demonstrated that ALW peptide ameliorates the murine model of LN, possibly through inhibiting renal IgG deposition and relevant tissue inflammation and fibrosis.
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      name:Core Research Laboratory, The Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, China
      name:Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, China
      name:Department of Nephrology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China
      name:Department of Dermatology, The Second Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, China

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